Treatment of severe hypophosphatemia.

Abstract:

:Aspects of phosphate biochemistry pertinent to therapy, the distribution of phosphorus in body compartments, therapeutic phosphorus preparations, prevention of hypophosphatemia, therapeutic guidelines, and side-effects of phosphorus therapy are reviewed. Severe hypophosphatemia (less than 0.32 mmol/litre or less than 1 mg/dl) can occur with normal or depleted body stores. Because a large amount of phosphorus may shift rapidly between the extracellular and intracellular or bone compartments, the size of a possible total body deficit cannot be estimated from the serum phosphorus level. Similar shifts may occur unpredictably during repair of hypophosphatemia. Therefore, correction of hypophosphatemia in any patient must be empiric and the response of serum levels to therapy should be followed closely. We discuss a method likely to correct hypophosphatemia while minimizing side-effects.

journal_name

Ann Intern Med

authors

Lentz RD,Brown DM,Kjellstrand CM

doi

10.7326/0003-4819-89-6-941

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

941-4

issue

6

eissn

0003-4819

issn

1539-3704

journal_volume

89

pub_type

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