Inheritance of mitral valve prolapse: effect of age and sex on gene expression.

Abstract:

:To ascertain if mitral valve prolapse is inherited we studied 45 probands and 179 first-degree relatives. Echocardiographic mitral prolapse was present in 54 of 179 first-degree relatives (30%); at least one first-degree relative was affected in 29 families, including members of two generations in 23 families. The number of affected persons in the 54 sibships fell within the range predicted for autosomal dominant inheritance. The familial prevalence of prolapse was similar whether or not the proband had characteristic symptoms, auscultatory abnormalities, electrocardiographic findings, thoracic bony abnormalities, or coexistent heart disease. Mitral prolapse occurred in 37 of 90 women (41%) but 17 of 89 men (19%; p less than 0.005), and in 51 of 143 adults (35%) but only 3 of 36 children aged 1 to 15 (p less than 0.005). Mitral valve prolapse is an inherited autosomal dominant condition irrespective of clinical findings, and the mitral prolapse gene shows age and sex dependent expression. Mitral valve prolapse appears to be the commonest mendelian cardiovascular abnormality in humans.

journal_name

Ann Intern Med

authors

Devereux RB,Brown WT,Kramer-Fox R,Sachs I

doi

10.7326/0003-4819-97-6-826

subject

Has Abstract

pub_date

1982-12-01 00:00:00

pages

826-32

issue

6

eissn

0003-4819

issn

1539-3704

journal_volume

97

pub_type

杂志文章
  • Medication dispensing errors and potential adverse drug events before and after implementing bar code technology in the pharmacy.

    abstract:BACKGROUND:Many dispensing errors made in hospital pharmacies can harm patients. Some hospitals are investing in bar code technology to reduce these errors, but data about its efficacy are limited. OBJECTIVE:To evaluate whether implementation of bar code technology reduced dispensing errors and potential adverse drug ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-145-6-200609190-00006

    authors: Poon EG,Cina JL,Churchill W,Patel N,Featherstone E,Rothschild JM,Keohane CA,Whittemore AD,Bates DW,Gandhi TK

    更新日期:2006-09-19 00:00:00

  • Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti Prospective Heart Study.

    abstract:BACKGROUND:The renin-angiotensin system is involved in adipocyte growth and differentiation and possibly in adipose tissue metabolism. OBJECTIVE:To investigate the association of polymorphism in the angiotensin-converting enzyme (ACE) I/D gene, angiotensinogen M235T gene, and angiotensin II type 1 receptor A1166C gene...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-138-1-200301070-00007

    authors: Strazzullo P,Iacone R,Iacoviello L,Russo O,Barba G,Russo P,D'Orazio A,Barbato A,Cappuccio FP,Farinaro E,Siani A,Olivetti Prospective Heart Study.

    更新日期:2003-01-07 00:00:00

  • Pulmonary hypertension in the CREST syndrome variant of progressive systemic sclerosis (scleroderma).

    abstract::Severe pulmonary hypertension without pulmonary fibrosis occurred in 10 patients with the CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia), reputedly a benign variant of progressive systemic sclerosis. Time from the initial symptom, Raynaud's phenomenon, to the r...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-86-4-394

    authors: Salerni R,Rodnan GP,Leon DF,Shaver JA

    更新日期:1977-04-01 00:00:00

  • ESPACOMP Medication Adherence Reporting Guideline (EMERGE).

    abstract::Research on assessing or managing medication adherence applies approaches from observational, interventional, and implementation science that spans many disciplines and demands coherent conceptualization, valid methods, appropriate analyses, and complete and accurate reporting. To ensure such reporting, the European S...

    journal_title:Annals of internal medicine

    pub_type: 指南,杂志文章

    doi:10.7326/M18-0543

    authors: De Geest S,Zullig LL,Dunbar-Jacob J,Helmy R,Hughes DA,Wilson IB,Vrijens B

    更新日期:2018-07-03 00:00:00

  • The toxicity of D-penicillamine in systemic sclerosis.

    abstract::We studied D-penicillamine toxicity in 259 patients with systemic sclerosis treated since 1972. The average daily dose of 635 mg was given for a mean of 1.8 years. Of patients with systemic sclerosis, 47% has side effects from D-penicillamine treatment, similar to the 56% of 807 patients with rheumatoid arthritis in s...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-104-5-699

    authors: Steen VD,Blair S,Medsger TA Jr

    更新日期:1986-05-01 00:00:00

  • Nonspecific interstitial pneumonitis: a common cause of pulmonary disease in the acquired immunodeficiency syndrome.

    abstract::During a 4.4-year period, nonspecific interstitial pneumonitis was seen in 41 of 110 (38%) patients with the acquired immunodeficiency syndrome and accounted for 32% (48/152) of all episodes of clinical pneumonitis. Diffuse alveolar damage was typically a feature of nonspecific interstitial pneumonitis, but neither lu...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-107-1-7

    authors: Suffredini AF,Ognibene FP,Lack EE,Simmons JT,Brenner M,Gill VJ,Lane HC,Fauci AS,Parrillo JE,Masur H

    更新日期:1987-07-01 00:00:00

  • Cisplatin, vinblastine, and bleomycin in advanced and recurrent ovarian germ-cell tumors. A trial of the Gynecologic Oncology Group.

    abstract:STUDY OBJECTIVE:To evaluate the efficacy of cisplatin-based combination chemotherapy in patients with advanced ovarian germ-cell tumors. DESIGN:Nonrandom prospective trial with endpoints of tumor response, results of repeat surgical exploration, progression-free interval, and survival. SETTING:Cooperative university-...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章

    doi:10.7326/0003-4819-111-1-22

    authors: Williams SD,Blessing JA,Moore DH,Homesley HD,Adcock L

    更新日期:1989-07-01 00:00:00

  • Critical perfusion pressure for renal function in patients with bilateral atherosclerotic renal vascular disease.

    abstract::We studied renal plasma flow and glomerular filtration rate during graded blood pressure reduction induced with sodium nitroprusside infusion in 16 hypertensive patients with atherosclerotic renovascular disease. Eight patients with unilateral disease tolerated pressure reduction from 205 +/- 9 (SE)/103 +/- 2 mm Hg to...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-102-3-308

    authors: Textor SC,Novick AC,Tarazi RC,Klimas V,Vidt DG,Pohl M

    更新日期:1985-03-01 00:00:00

  • A sustained mortality benefit from screening for abdominal aortic aneurysm.

    abstract:BACKGROUND:Longer-term mortality benefit and cost-effectiveness for abdominal aortic aneurysm (AAA) screening are uncertain. OBJECTIVE:To estimate the benefits, in terms of AAA-related and all-cause mortality, and cost-effectiveness of ultrasonography screening for AAA in a group that was invited to screening compared...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-146-10-200705150-00003

    authors: Kim LG,P Scott RA,Ashton HA,Thompson SG,Multicentre Aneurysm Screening Study Group.

    更新日期:2007-05-15 00:00:00

  • Cocaine-packet ingestion. Diagnosis, management, and natural history.

    abstract::We treated 50 patients who ingested packets of cocaine and developed a protocol for conservative medical management. Of the 50 patients, only 3 required emergency surgery. Surgery was precipitated by signs and symptoms of bowel obstruction in all cases. Six patients chose elective surgery. The rest of the patients pas...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-100-1-73

    authors: Caruana DS,Weinbach B,Goerg D,Gardner LB

    更新日期:1984-01-01 00:00:00

  • Low-molecular-weight heparin for women with unexplained recurrent pregnancy loss: a multicenter trial with a minimization randomization scheme.

    abstract:BACKGROUND:A daily injection of low-molecular-weight heparin (LMWH) is often prescribed to women with unexplained recurrent pregnancy loss (RPL), although evidence suggesting a benefit is questionable. OBJECTIVE:To determine whether LMWH increases ongoing pregnancy and live-birth rates in women with unexplained RPL. ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/M14-2062

    authors: Schleussner E,Kamin G,Seliger G,Rogenhofer N,Ebner S,Toth B,Schenk M,Henes M,Bohlmann MK,Fischer T,Brosteanu O,Bauersachs R,Petroff D,ETHIG II group.

    更新日期:2015-05-05 00:00:00

  • Using Public Cost Information During Low Back Pain Visits: A Qualitative Study.

    abstract:Background:Patients desire information about health care costs because they are increasingly responsible for these costs. Public Web sites that offer cost information could inform provider-patient discussions of costs at the point of care. Objective:To evaluate tools to facilitate the use of publicly available cost in...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.7326/M18-2223

    authors: Fox KS,Gray CE,Williamson ME,MacKenzie JA

    更新日期:2019-05-07 00:00:00

  • Web Exclusive. Annals for Hospitalists Inpatient Notes - Preparing for Battle: How Hospitalists Can Manage the Stress of COVID-19.

    abstract::[Figure: see text]. ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M20-1897

    authors: Morganstein JC

    更新日期:2020-05-19 00:00:00

  • Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism.

    abstract:BACKGROUND:The optimum duration of anticoagulant therapy after an episode of deep venous thrombosis (DVT) is controversial. Contributing to the controversy is uncertainty about whether residual venous thrombosis, as assessed by repeated ultrasonography over time, increases the risk for recurrent thromboembolism. OBJEC...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-137-12-200212170-00008

    authors: Prandoni P,Lensing AW,Prins MH,Bernardi E,Marchiori A,Bagatella P,Frulla M,Mosena L,Tormene D,Piccioli A,Simioni P,Girolami A

    更新日期:2002-12-17 00:00:00

  • Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group.

    abstract::For the diagnosis of M7, the bone marrow aspirate shows a leukemic cell infiltrate that comprises 30% or more of all cells. These cells are identified as being of megakaryocyte lineage by the platelet peroxidase reaction on electron microscopy or by tests with monoclonal or polyclonal platelet-specific antibodies. Mye...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-3-460

    authors: Bennett JM,Catovsky D,Daniel MT,Flandrin G,Galton DA,Gralnick HR,Sultan C

    更新日期:1985-09-01 00:00:00

  • Tracheal occlusion pressure: a simple index to monitor respiratory muscle fatigue during acute respiratory failure in patients with chronic obstructive pulmonary disease.

    abstract:STUDY OBJECTIVE:To assess respiratory muscle fatigue in acute respiratory failure in patients with chronic obstructive pulmonary disease and evaluate its influence on weaning patients from mechanical ventilation. DESIGN AND PATIENTS:We studied the time course of tracheal occlusion pressure (P0.1) and high-to-low ratio...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-108-6-800

    authors: Murciano D,Boczkowski J,Lecocguic Y,Emili JM,Pariente R,Aubier M

    更新日期:1988-06-01 00:00:00

  • The metyrapone and dexamethasone suppression tests for the differential diagnosis of the adrenocorticotropin-dependent Cushing syndrome: a comparison.

    abstract:OBJECTIVE:To develop criteria for interpreting results of the metyrapone test for the differential diagnosis of the adrenocorticotropin (ACTH)-dependent Cushing syndrome and to compare its diagnostic accuracy with that of the high-dose dexamethasone suppression test. DESIGN:Retrospective cohort study. SETTING:Inpatie...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-121-5-199409010-00002

    authors: Avgerinos PC,Yanovski JA,Oldfield EH,Nieman LK,Cutler GB Jr

    更新日期:1994-09-01 00:00:00

  • Is embolic risk conditioned by location of deep venous thrombosis?

    abstract::Sixty-eight patients clinically suspected of having (33), or at high risk for (35), deep venous thrombosis were studied with contrast venography, radiofibrinogen leg scanning, and impedance plethysmography as well as ventilation and perfusion lung scans. Thrombosis limited to the veins in the calf of the leg (unilater...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-94-4-439

    authors: Moser KM,LeMoine JR

    更新日期:1981-04-01 00:00:00

  • Early disaster response in Haiti: the Israeli field hospital experience.

    abstract::The earthquake that struck Haiti in January 2010 caused an estimated 230,000 deaths and injured approximately 250,000 people. The Israel Defense Forces Medical Corps Field Hospital was fully operational on site only 89 hours after the earthquake struck and was capable of providing sophisticated medical care. During th...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-153-1-201007060-00253

    authors: Kreiss Y,Merin O,Peleg K,Levy G,Vinker S,Sagi R,Abargel A,Bartal C,Lin G,Bar A,Bar-On E,Schwaber MJ,Ash N

    更新日期:2010-07-06 00:00:00

  • The effect of different attribution rules on individual physician cost profiles.

    abstract:BACKGROUND:Some health plans profile physicians on the basis of their relative costs and use these profiles to assign physicians to cost categories. Physician organizations have questioned whether the rules used to attribute costs to a physician affect the cost category to which that physician is assigned. OBJECTIVE:T...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-152-10-201005180-00005

    authors: Mehrotra A,Adams JL,Thomas JW,McGlynn EA

    更新日期:2010-05-18 00:00:00

  • HemoQuant, a new quantitative assay for fecal hemoglobin. Comparison with Hemoccult.

    abstract::HemoQuant, an assay based on heme-derived porphyrin, quantifies both total fecal hemoglobin ant that fraction already converted to porphyrin by gut flora (the intestinal converted fraction). Recovery by HemoQuant of blood added to stools exceeded 99% and was not affected by ascorbic acid, iron, or other additives. Hem...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-101-3-297

    authors: Ahlquist DA,McGill DB,Schwartz S,Taylor WF,Ellefson M,Owen RA

    更新日期:1984-09-01 00:00:00

  • Support from hospital to home for elders: a randomized trial.

    abstract:BACKGROUND:Hospitals are implementing discharge support programs to reduce readmissions, and these programs have had mixed success. OBJECTIVE:To examine whether a peridischarge, nurse-led intervention decreased emergency department (ED) visits or readmissions among ethnically and linguistically diverse older patients ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.7326/M14-0094

    authors: Goldman LE,Sarkar U,Kessell E,Guzman D,Schneidermann M,Pierluissi E,Walter B,Vittinghoff E,Critchfield J,Kushel M

    更新日期:2014-10-07 00:00:00

  • Diffuse esophageal spasm: a reappraisal.

    abstract::With the renewed interest in esophageal motility disorders, diffuse esophageal spasm is being diagnosed more frequently. In many clinical settings, however, the term is used as a synonym for noncardiac chest pain. Our review of the literature and broad clinical experience in studying the motility patterns of healthy s...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-100-2-242

    authors: Richter JE,Castell DO

    更新日期:1984-02-01 00:00:00

  • Coccidioidomycosis of the thyroid.

    abstract::In two patients with thyroiditis caused by Coccidioides immitis, presented thyroid symptoms and findings were characteristic of subacute thyroiditis. Fine needle aspiration biopsy of the thyroid proved useful in establishing the diagnosis of coccidioidomycosis. This is the first report of coccidioidomycosis presenting...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-91-3-409

    authors: Loeb JM,Livermore BM,Wofsy D

    更新日期:1979-09-01 00:00:00

  • Growth hormone replacement in healthy older men improves body composition but not functional ability.

    abstract:OBJECTIVE:To determine whether growth hormone replacement in older men improves functional ability. DESIGN:Randomized, controlled, double-blind trial. SETTING:General community. PATIENTS:52 healthy men older than 69 years of age with well-preserved functional ability but low baseline insulin-like growth factor 1 lev...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-124-8-199604150-00002

    authors: Papadakis MA,Grady D,Black D,Tierney MJ,Gooding GA,Schambelan M,Grunfeld C

    更新日期:1996-04-15 00:00:00

  • Cardiovascular mortality associated with 5 leading risk factors: national and state preventable fractions estimated from survey data.

    abstract:BACKGROUND:Impressive decreases in cardiovascular mortality have been achieved through risk factor reduction and clinical intervention, yet cardiovascular disease remains a leading cause of death nationally. OBJECTIVE:To estimate up-to-date preventable fractions of cardiovascular mortality associated with elimination ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M14-1753

    authors: Patel SA,Winkel M,Ali MK,Narayan KM,Mehta NK

    更新日期:2015-08-18 00:00:00

  • Medical complications and medical management of bulimia.

    abstract::The syndrome of bulimia is a common disorder and can be associated with serious psychological and physical morbidity. Unfortunately, many patients are reluctant to discuss their symptoms with their physicians and few clues can be found on physical examination to aid in the diagnosis. Possible physical signs include ul...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-107-1-71

    authors: Mitchell JE,Seim HC,Colon E,Pomeroy C

    更新日期:1987-07-01 00:00:00

  • Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study.

    abstract:BACKGROUND:High intake of folate may reduce risk for colon cancer, but the dosage and duration relations and the impact of dietary compared with supplementary sources are not well understood. OBJECTIVE:To evaluate the relation between folate intake and incidence of colon cancer. DESIGN:Prospective cohort study. SETT...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-129-7-199810010-00002

    authors: Giovannucci E,Stampfer MJ,Colditz GA,Hunter DJ,Fuchs C,Rosner BA,Speizer FE,Willett WC

    更新日期:1998-10-01 00:00:00

  • Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature.

    abstract:PURPOSE:To evaluate the possibility that fibrinogen represents a cardiovascular risk factor. DATA IDENTIFICATION:A computerized literature search (1980 to 1992) identified all published epidemiologic studies on fibrinogen and cardiovascular disease. Clinical and basic research data were found by separate searches. Ref...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/0003-4819-118-12-199306150-00008

    authors: Ernst E,Resch KL

    更新日期:1993-06-15 00:00:00

  • Functional somatic syndromes.

    abstract::The term functional somatic syndrome has been applied to several related syndromes characterized more by symptoms, suffering, and disability than by consistently demonstrable tissue abnormality. These syndromes include multiple chemical sensitivity, the sick building syndrome, repetition stress injury, the side effect...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-130-11-199906010-00016

    authors: Barsky AJ,Borus JF

    更新日期:1999-06-01 00:00:00