Fatal hepatic necrosis due to pyrimethamine-sulfadoxine (Fansidar).

abstract：OBJECTIVE:To define the temporal characteristics of cocaine-induced coronary vasoconstriction in humans and to assess the relation between cocaine-induced coronary vasoconstriction and the blood concentration of cocaine and its main metabolites. DESIGN:Randomized, double-blind, controlled clinical trial. SETTING:Card...

journal_title：Annals of internal medicine

authors： Brogan WC 3rd,Lange RA,Glamann DB,Hillis LD

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic continues to surge in the United States and globally. OBJECTIVE:To describe the epidemiology of COVID-19-related critical illness, including trends in outcomes and care delivery. DESIGN:Single-health system, multihospital retrospective cohort study. SETTING...

journal_title：Annals of internal medicine

authors： Anesi GL,Jablonski J,Harhay MO,Atkins JH,Bajaj J,Baston C,Brennan PJ,Candeloro CL,Catalano LM,Cereda MF,Chandler JM,Christie JD,Collins T,Courtright KR,Fuchs BD,Gordon E,Greenwood JC,Gudowski S,Hanish A,Hanson Iii C

更新日期：2021-01-19 00:00:00

abstract：STUDY OBJECTIVE:To determine the relative importance of adiposity and fat distribution to cardiovascular risk profile. DESIGN:A cross-sectional study. SETTING:Clinical research center funded by the National Institutes of Health. PATIENTS:Convenience sample of 33 healthy premenopausal women with a wide range of body ...

journal_title：Annals of internal medicine

authors： Peiris AN,Sothmann MS,Hoffmann RG,Hennes MI,Wilson CR,Gustafson AB,Kissebah AH

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Few treatments for back pain are supported by strong scientific evidence. Conventional treatments, although widely used, have had limited success. Dissatisfied patients have, therefore, turned to complementary and alternative medical therapies and providers for care for back pain. PURPOSE:To provide a rigor...

journal_title：Annals of internal medicine

authors： Cherkin DC,Sherman KJ,Deyo RA,Shekelle PG

更新日期：2003-06-03 00:00:00

abstract：OBJECTIVE:To determine the efficacy of ciprofloxacin therapy in eradicating convalescent fecal excretion of salmonellae after acute salmonellosis. DESIGN:Randomized, placebo-controlled, double-blind trial of ciprofloxacin, with prospective follow-up of nonparticipants. SETTING:An acute care community hospital experie...

journal_title：Annals of internal medicine

authors： Neill MA,Opal SM,Heelan J,Giusti R,Cassidy JE,White R,Mayer KH

更新日期：1991-02-01 00:00:00

abstract：:The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including PIER (Physicians' Information and Education Resource) and MKSAP (Medical Knowledge and Self Assessment Program). Annals of Internal Medicine editors develop In the Clinic f...

journal_title：Annals of internal medicine

authors： McDermott MT

更新日期：2009-12-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of a nurse-managed intervention for smoking cessation in patients who have had a myocardial infarction. DESIGN:Randomized, with a 6-month treatment period and a 6-month follow-up. SETTING:Kaiser Foundation hospitals in Redwood City, Santa Clara, Hayward, and San Jose, Californi...

journal_title：Annals of internal medicine

authors： Taylor CB,Houston-Miller N,Killen JD,DeBusk RF

更新日期：1990-07-15 00:00:00

abstract：OBJECTIVE:To determine the toxicity and efficacy of low-dose interferon-alpha therapy in inducing remissions and prolonging survival in patients with chronic myeloid leukemia. DESIGN:Phase II evaluation and comparison with historical control patients and other series in which the investigators used higher interferon-a...

journal_title：Annals of internal medicine

authors： Schofield JR,Robinson WA,Murphy JR,Rovira DK

更新日期：1994-11-15 00:00:00

abstract：OBJECTIVE:To describe the effects of human immunodeficiency virus (HIV) infection on the serologic manifestations and response to treatment of syphilis in intravenous drug users. DESIGN:Cohort study of intravenous drug users. SETTING:Medical clinic in a hospital-based methadone maintenance treatment program in New Yo...

journal_title：Annals of internal medicine

authors： Gourevitch MN,Selwyn PA,Davenny K,Buono D,Schoenbaum EE,Klein RS,Friedland GH

更新日期：1993-03-01 00:00:00

abstract：Background:Little is known about how physician time is allocated in ambulatory care. Objective:To describe how physician time is spent in ambulatory practice. Design:Quantitative direct observational time and motion study (during office hours) and self-reported diary (after hours). Setting:U.S. ambulatory care in 4 ...

journal_title：Annals of internal medicine

authors： Sinsky C,Colligan L,Li L,Prgomet M,Reynolds S,Goeders L,Westbrook J,Tutty M,Blike G

更新日期：2016-12-06 00:00:00

abstract：:We performed selective venous catheterization and sampling for ACTH in six patients with ACTH-secreting pituitary adenomas (Cushing's disease) and four patients with occult ectopic ACTH-secreting neoplasms. In five patients with Cushing's disease in whom the inferior petrosal sinus could be catheterized, ACTH levels w...

journal_title：Annals of internal medicine

authors： Findling JW,Aron DC,Tyrrell JB,Shinsako JH,Fitzgerald PA,Norman D,Wilson CB,Forsham PH

更新日期：1981-05-01 00:00:00

abstract：:Sixty-nine out of a kindred of 100 members covering five generations were examined and studied, and 34 were hypercalcemic. Sixteen subjects were believed, on the basis of laboratory and clinical observations, to have primary hyperparathyroidism. Eight patients were subjected to exhaustive study to identify polyendocri...

journal_title：Annals of internal medicine

authors： Goldsmith RE,Sizemore GW,Chen IW,Zalme E,Altemeier WA

更新日期：1976-01-01 00:00:00

abstract：:Low back pain is common, but a herniated intervertebral disk is the cause in only a small percentage of cases. Most symptomatic disk herniations result in clinical manifestations (pain, reflex loss, muscle weakness) that resolve with conservative therapy, and only 5% to 10% of patients require surgery. Sciatica is usu...

journal_title：Annals of internal medicine

authors： Deyo RA,Loeser JD,Bigos SJ

更新日期：1990-04-15 00:00:00

abstract：:As a result of important advances in medical imaging, the oral cholecystogram is no longer the primary test of gallbladder function and anatomy. Real-time ultrasonography and cholescintigraphy, both highly sensitive and specific tests, are the two major methods for assessing gallbladder pathology. Oral cholecystograph...

journal_title：Annals of internal medicine

authors： Marton KI,Doubilet P

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:To describe the clinical, laboratory, and echocardiographic findings in a large group of patients with right-sided endocarditis and to determine whether any of these findings is predictive of prognosis. DESIGN:Retrospective survey of medical records to evaluate the course of hospitalization with follow-up on...

journal_title：Annals of internal medicine

authors： Hecht SR,Berger M

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:The accuracy and harms of brief cognitive tests for identifying clinical Alzheimer-type dementia (CATD) are uncertain. PURPOSE:To summarize evidence on accuracy and harms of brief cognitive tests for CATD in older adults with suspected cognitive impairment. DATA SOURCES:Electronic bibliographic databases (...

journal_title：Annals of internal medicine

authors： Hemmy LS,Linskens EJ,Silverman PC,Miller MA,Talley KMC,Taylor BC,Ouellette JM,Greer NL,Wilt TJ,Butler M,Fink HA

更新日期：2020-05-19 00:00:00

abstract：OBJECTIVE:To determine the relations among esophageal dysfunction, gastroesophageal reflux, and lung involvement in patients with systemic sclerosis. DESIGN:Retrospective review of esophageal motility, esophageal pH, and pulmonary function data. SETTING:University hospital outpatient clinic and community. PATIENTS:3...

journal_title：Annals of internal medicine

authors： Troshinsky MB,Kane GC,Varga J,Cater JR,Fish JE,Jimenez SA,Castell DO

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Menopausal hormone therapy to prevent chronic conditions is currently not recommended because of its adverse effects. PURPOSE:To update evidence about the effectiveness of hormone therapy in reducing risk for chronic conditions and adverse effects, and to examine whether outcomes vary among women in differe...

journal_title：Annals of internal medicine

authors： Nelson HD,Walker M,Zakher B,Mitchell J

更新日期：2012-07-17 00:00:00

abstract：OBJECTIVE:To evaluate the amount of variation in in-hospital mortality and length of intensive care unit (ICU) stay that can be accounted for by clinical data available at ICU admission. DESIGN:Inception cohort study. SETTING:Forty-two ICUs in 40 hospitals, including 26 hospitals that were randomly selected and 14 la...

journal_title：Annals of internal medicine

authors： Knaus WA,Wagner DP,Zimmerman JE,Draper EA

更新日期：1993-05-15 00:00:00

abstract：OBJECTIVE:To evaluate the risk for chronic renal disease associated with regular use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs). DESIGN:Multicenter case-control study. PATIENTS:Patients were 554 North Carolina residents (age range, 30 to 79 years) hospitalized between 1980 and 1982 with a discharge d...

journal_title：Annals of internal medicine

authors： Sandler DP,Burr FR,Weinberg CR

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:To determine if polyvalent IgG is promising therapy for severe IgG nephropathy. DESIGN:Open prospective cohort study. SETTING:Referral nephrology unit. PATIENTS:11 adult patients with severe IgA nephropathy (9 who had idiopathic disease and 2 who had Henoch-Schönlein purpura) and indicators of poor prognos...

journal_title：Annals of internal medicine

authors： Rostoker G,Desvaux-Belghiti D,Pilatte Y,Petit-Phar M,Philippon C,Deforges L,Terzidis H,Intrator L,André C,Adnot S,Bonin P,Bierling P,Remy P,Lagrue G,Lang P,Weil B

更新日期：1994-03-15 00:00:00

abstract：:Impairment of penicillin G excretion in renal failure may result in life-threatening, dose-related toxicity. We report a method for achieving a desired mean serum penicillin G concentration in patients with renal failure, with minimal risk of both undertreatment and drug toxicity. The method is based on the linear rel...

journal_title：Annals of internal medicine

authors： Bryan CS,Stone WJ

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:HIV-infected patients with sustained immunologic improvement from antiretroviral therapy may be able to discontinue chemoprophylaxis against Pneumocystis carinii pneumonia (PCP). OBJECTIVE:To compare PCP incidence in HIV-infected patients who had sustained CD4+ lymphocyte counts greater than 200 cells/mm3 a...

journal_title：Annals of internal medicine

authors： Yangco BG,Von Bargen JC,Moorman AC,Holmberg SD

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:The optimal strategy for diagnosis of deep venous thrombosis (DVT) is less well established for the upper extremities than for the lower extremities. Duplex color ultrasonography can be difficult to perform in the upper extremities because of their anatomy, and contrast venography is often indicated. Moreove...

journal_title：Annals of internal medicine

authors： Baarslag HJ,van Beek EJ,Koopman MM,Reekers JA

更新日期：2002-06-18 00:00:00

abstract：BACKGROUND:Successful outcomes after cardiopulmonary resuscitation remain disappointingly infrequent, in animal studies, administration of exogenous vasopressin during closed- and open-chest cardiopulmonary resuscitation has recently been shown to be more effective than optimal doses of epinephrine in improving vital o...

journal_title：Annals of internal medicine

authors： Lindner KH,Prengel AW,Brinkmann A,Strohmenger HU,Lindner IM,Lurie KG

更新日期：1996-06-15 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of housestaff physician reporting as a method for identifying adverse events on a medical service and to compare the physician reporting mechanism with a retrospective record review mechanism. SETTING:Medical service of an urban, university-affiliated teaching hospital. DESIGN:Co...

journal_title：Annals of internal medicine

authors： O'Neil AC,Petersen LA,Cook EF,Bates DW,Lee TH,Brennan TA

更新日期：1993-09-01 00:00:00

abstract：:We treated 50 patients who ingested packets of cocaine and developed a protocol for conservative medical management. Of the 50 patients, only 3 required emergency surgery. Surgery was precipitated by signs and symptoms of bowel obstruction in all cases. Six patients chose elective surgery. The rest of the patients pas...

journal_title：Annals of internal medicine

authors： Caruana DS,Weinbach B,Goerg D,Gardner LB

更新日期：1984-01-01 00:00:00

abstract：:Clinical ecologists propose the existence of a unique illness in which multiple environmental chemicals, foods, drugs, and endogenous C. albicans have a toxic effect on the immune system, thereby adversely affecting other bodily functions. The proposal uses some concepts that superficially resemble those that apply to...

journal_title：Annals of internal medicine

authors：

更新日期：1989-07-15 00:00:00

abstract：SOURCE CITATION:Cao B, Wang Y, Wen D, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020;382:1787-99. 32187464. ...

journal_title：Annals of internal medicine

authors： Yang P,Tekwani S,Martin GS

更新日期：2020-06-16 00:00:00

abstract：:Forceful new demands for accountability in medicine are arising from many interested parties. To maintain professional standards, physicians need to establish which demands are desirable and which are not. We adopt a model of stratified accountability that includes three major components: the accountable parties, the ...

journal_title：Annals of internal medicine

authors： Emanuel LL

更新日期：1996-01-15 00:00:00