Patient safety is not enough: targeting quality improvements to optimize the health of the population.

abstract：:Very low calorie diets used to treat moderate and severe obesity produce average weight losses of 20 kg in 12 weeks. This paper reviews the development of very low calorie diets from research on fasting in the late 1950s and examines data on the amount of dietary protein needed to achieve positive nitrogen balance. Th...

journal_title：Annals of internal medicine

authors： Wadden TA,Stunkard AJ,Brownell KD

更新日期：1983-11-01 00:00:00

abstract：:Traditionally, acupuncture is embedded in naturalistic theories that are compatible with Confucianism and Taoism. Such ideas as yin-yang, qi, dampness, and wind represent East Asian conceptual frameworks that emphasize the reliability of ordinary, human sensory awareness. Many physicians who practice acupuncture rejec...

journal_title：Annals of internal medicine

authors： Kaptchuk TJ

更新日期：2002-03-05 00:00:00

abstract：:The data from population-based, randomized trials of the mammographic screening of women aged 40 to 49 years are limited by retrospective subgroup analysis, low statistical power, and the use of older mammographic techniques. Nonetheless, meta-analysis involving the most recently reported data from all similarly desig...

journal_title：Annals of internal medicine

authors： Sickles EA,Kopans DB

更新日期：1995-04-01 00:00:00

abstract：:Disseminated candidiasis has become an important infection, particularly in immunocompromised and postoperative patients. Although serologic tests may, in some settings, facilitate a premortem diagnosis, the disease is usually diagnosed by comprehensive clinical evaluation. Detection of the relatively newly recognized...

journal_title：Annals of internal medicine

authors： Edwards JE Jr,Lehrer RI,Stiehm ER,Fischer TJ,Young LS

更新日期：1978-07-01 00:00:00

abstract：:The expression of ischemic heart disease was studied in a large kindred with familial hypercholesterolemia. Tendon xanthomas, multiple generation transmission, and the appearance of bimodality in the distributions of total and low-density lipoprotein cholesterol were found. The segregation ratio was 0.9 in females and...

journal_title：Annals of internal medicine

authors： Streja D,Steiner G,Kwiterovich PO Jr

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases. OBJECTIVE:To compare the benefits and side effects of TwHF extract with those of sulfasalazine for the treatment of active rheumatoid arthritis. DESIGN:Ra...

journal_title：Annals of internal medicine

authors： Goldbach-Mansky R,Wilson M,Fleischmann R,Olsen N,Silverfield J,Kempf P,Kivitz A,Sherrer Y,Pucino F,Csako G,Costello R,Pham TH,Snyder C,van der Heijde D,Tao X,Wesley R,Lipsky PE

更新日期：2009-08-18 00:00:00

abstract：OBJECTIVE:To determine whether a cytogenetic response after interferon-alpha therapy in patients with chronic myelogenous leukemia is independently associated with improved survival. DESIGN:Retrospective analysis. PATIENTS:274 patients with a diagnosis of Philadelphia chromosome-positive chronic myelogenous leukemia ...

journal_title：Annals of internal medicine

authors： Kantarjian HM,Smith TL,O'Brien S,Beran M,Pierce S,Talpaz M

更新日期：1995-02-15 00:00:00

abstract：OBJECTIVE:To determine whether prolonging the duration of tamoxifen administration beyond the cessation of a combined chemotherapy regimen benefits patients with primary breast cancer with positive findings in axillary nodes who benefit initially from the combined regimen. DESIGN:Nonrandomized, nonconcurrent cohort st...

journal_title：Annals of internal medicine

authors： Fisher B,Brown A,Wolmark N,Redmond C,Wickerham DL,Wittliff J,Dimitrov N,Legault-Poisson S,Schipper H,Prager D

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Many states have laws requiring mammography facilities to tell women with dense breasts and negative results on screening mammography to discuss supplemental screening tests with their providers. The most readily available supplemental screening method is ultrasonography, but little is known about its effect...

journal_title：Annals of internal medicine

authors： Sprague BL,Stout NK,Schechter C,van Ravesteyn NT,Cevik M,Alagoz O,Lee CI,van den Broek JJ,Miglioretti DL,Mandelblatt JS,de Koning HJ,Kerlikowske K,Lehman CD,Tosteson AN

更新日期：2015-02-03 00:00:00

abstract：OBJECTIVE:To determine if polyvalent IgG is promising therapy for severe IgG nephropathy. DESIGN:Open prospective cohort study. SETTING:Referral nephrology unit. PATIENTS:11 adult patients with severe IgA nephropathy (9 who had idiopathic disease and 2 who had Henoch-Schönlein purpura) and indicators of poor prognos...

journal_title：Annals of internal medicine

authors： Rostoker G,Desvaux-Belghiti D,Pilatte Y,Petit-Phar M,Philippon C,Deforges L,Terzidis H,Intrator L,André C,Adnot S,Bonin P,Bierling P,Remy P,Lagrue G,Lang P,Weil B

更新日期：1994-03-15 00:00:00

abstract：OBJECTIVE:To determine the most effective and safe dose of enoxaparin to prevent deep venous thrombosis in high-risk surgical patients. DESIGN:A double-blind, randomized, multicenter clinical trial. SETTING:Private, university, and government hospitals in the United States. PATIENTS:572 patients having elective hip ...

journal_title：Annals of internal medicine

authors： Spiro TE,Johnson GJ,Christie MJ,Lyons RM,MacFarlane DE,Blasier RB,Tremaine MD

更新日期：1994-07-15 00:00:00

abstract：:Tax incentives can provide a large financial impetus to change behavior. Current U.S. law establishes a substantial discontinuity in the amount of estate tax that many patients will have to pay in 2010: During this year only, the tax rate drops to zero. This article discusses concerns regarding the sharp change in tax...

journal_title：Annals of internal medicine

authors： Mendenhall GS

更新日期：2008-12-02 00:00:00

abstract：:The scope of recent literature on the concept of "vulnerable plaque" was reviewed by examining 463 abstracts of primary and review articles identified through MEDLINE (2003 to April 2010). Proposed definition criteria of vulnerable plaque included active inflammation, a thin cap with a large lipid core, endothelial de...

journal_title：Annals of internal medicine

authors： Alsheikh-Ali AA,Kitsios GD,Balk EM,Lau J,Ip S

更新日期：2010-09-21 00:00:00

abstract：BACKGROUND:Dietary trans fat increases risk for coronary heart disease. In 2006, New York City (NYC) passed the first regulation in the United States restricting trans fat use in restaurants. OBJECTIVE:To assess the effect of the NYC regulation on the trans and saturated fat content of fast-food purchases. DESIGN:Cro...

journal_title：Annals of internal medicine

authors： Angell SY,Cobb LK,Curtis CJ,Konty KJ,Silver LD

更新日期：2012-07-17 00:00:00

abstract：:Concierge medical practices, which advertise expanded access to care and individualized attention, collect charges both from insurance companies and directly from their patients. Some bill hundreds of dollars for one-time "executive" physicals, whereas others have patients pay annual retainer fees. Yet, virtually no d...

journal_title：Annals of internal medicine

authors： Stillman M

更新日期：2010-03-16 00:00:00

abstract：BACKGROUND:Advice and exercise are widely recommended for subacute low back pain, but the effectiveness of these interventions is unclear. OBJECTIVE:To investigate the effectiveness of physiotherapist-prescribed exercise, advice, or both for subacute low back pain. DESIGN:Factorial randomized, placebo-controlled tria...

journal_title：Annals of internal medicine

authors： Pengel LH,Refshauge KM,Maher CG,Nicholas MK,Herbert RD,McNair P

更新日期：2007-06-05 00:00:00

abstract：:A severe shortage of organs greatly limits the ability to deliver the miracle of transplantation to people suffering from end-stage organ disease. Contributing to this shortage is a high rate of refusal among families who are asked for permission to remove organs from a recently deceased relative. Mandated choice offe...

journal_title：Annals of internal medicine

authors： Spital A

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Exercise rehabilitation programs increase treadmill walking performance in patients with peripheral arterial disease (PAD) and intermittent claudication. However, it is unknown whether patients with PAD who walk for exercise regularly have less functional decline than those with less walking activity. OBJEC...

journal_title：Annals of internal medicine

authors： McDermott MM,Liu K,Ferrucci L,Criqui MH,Greenland P,Guralnik JM,Tian L,Schneider JR,Pearce WH,Tan J,Martin GJ

更新日期：2006-01-03 00:00:00

abstract：:Many investigations consider the presence of e antigen (HBeAg) valuable in predicting which patients with acute hepatitis B are at risk of remaining infected and developing chronic liver disease. We tested this hypothesis in a retrospective study of serial samples from patients undergoing long-term hemodialysis. We fo...

journal_title：Annals of internal medicine

authors： Werner BG,Blumberg BS

更新日期：1978-09-01 00:00:00

abstract：:The approximately 1.2 million inmates in U.S. correctional institutions have a high prevalence of communicable diseases, such as human immunodeficiency virus (HIV) infection, tuberculosis, hepatitis B virus infection, and gonorrhea. Before their incarceration, most inmates had limited access to health care, which, tog...

journal_title：Annals of internal medicine

authors： Glaser JB,Greifinger RB

更新日期：1993-01-15 00:00:00

abstract：BACKGROUND:Injection insulin therapy is not readily accepted by patients and many health care providers; therefore, less invasive options for insulin therapy are desirable. PURPOSE:To examine the efficacy, safety, and patient acceptability of inhaled insulin therapy in nonpregnant adults with diabetes mellitus. DATA ...

journal_title：Annals of internal medicine

authors： Ceglia L,Lau J,Pittas AG

更新日期：2006-11-07 00:00:00

abstract：:Congenital adrenal hyperplasia describes a group of inherited autosomal recessive disorders characterized by an enzymatic defect in cortisol biosynthesis, compensatory increases in corticotropin secretion, and adrenocortical hyperplasia. 21-Hydroxylase deficiency is responsible for more than 95% of cases and is one of...

journal_title：Annals of internal medicine

authors： Merke DP,Bornstein SR,Avila NA,Chrousos GP

更新日期：2002-02-19 00:00:00

abstract：:Medical devices have become an integral part of hospital-based care but also predispose patients to more than 850 000 device-related infections annually. Devices predispose to infection by damaging or invading epithelial and mucosal barriers to infection, by supporting growth of microorganisms and thus serving as rese...

journal_title：Annals of internal medicine

authors： Stamm WE

更新日期：1978-11-01 00:00:00

abstract：Background:The 2013 cholesterol management guidelines from the American College of Cardiology and American Heart Association (ACC/AHA) recommend lipid screening in all adults older than 20 years to identify those at increased risk for atherosclerotic cardiovascular disease (ASCVD). Statins may be considered for patient...

journal_title：Annals of internal medicine

authors： Patel KK,Taksler GB,Hu B,Rothberg MB

更新日期：2017-06-20 00:00:00

abstract：:Although disease caused by Arizona hinshawii is known to resemble the spectrum of clinical syndromes seen with Salmonella infections, little is known of their sensitivity to antimicrobials. We present three cases that are illustrative of Arizona sepsis, localized infection, or both; review the literature; and report s...

journal_title：Annals of internal medicine

authors： Johnson RH,Lutwick LI,Huntley GA,Vosti KL

更新日期：1976-11-01 00:00:00

abstract：:Antinuclear antibodies are present in most patients receiving procainamide. To ascertain whether IgG antiguanosine antibodies are associated with the development of the symptoms of systemic lupus erythematosus, we compared the levels of these antibodies in the sera of 65 patients receiving procainamide: 18 with procai...

journal_title：Annals of internal medicine

authors： Weisbart RH,Yee WS,Colburn KK,Whang SH,Heng MK,Boucek RJ

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Oral sildenafil and intravenous epoprostenol have independently been shown to be effective in patients with pulmonary arterial hypertension. OBJECTIVE:To investigate the effect of adding oral sildenafil to long-term intravenous epoprostenol in patients with pulmonary arterial hypertension. DESIGN:A 16-week...

journal_title：Annals of internal medicine

authors： Simonneau G,Rubin LJ,Galiè N,Barst RJ,Fleming TR,Frost AE,Engel PJ,Kramer MR,Burgess G,Collings L,Cossons N,Sitbon O,Badesch DB,PACES Study Group.

更新日期：2008-10-21 00:00:00

abstract：BACKGROUND:The Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 global treatment target aims to achieve 73% virologic suppression among HIV-infected persons worldwide by 2020. OBJECTIVE:To estimate the clinical and economic value of reaching this ambitious goal in South Africa, by using a microsimulation m...

journal_title：Annals of internal medicine

authors： Walensky RP,Borre ED,Bekker LG,Resch SC,Hyle EP,Wood R,Weinstein MC,Ciaranello AL,Freedberg KA,Paltiel AD

更新日期：2016-09-06 00:00:00

abstract：:Forceful new demands for accountability in medicine are arising from many interested parties. To maintain professional standards, physicians need to establish which demands are desirable and which are not. We adopt a model of stratified accountability that includes three major components: the accountable parties, the ...

journal_title：Annals of internal medicine

authors： Emanuel LL

更新日期：1996-01-15 00:00:00

abstract：BACKGROUND:Longer-term mortality benefit and cost-effectiveness for abdominal aortic aneurysm (AAA) screening are uncertain. OBJECTIVE:To estimate the benefits, in terms of AAA-related and all-cause mortality, and cost-effectiveness of ultrasonography screening for AAA in a group that was invited to screening compared...

journal_title：Annals of internal medicine

authors： Kim LG,P Scott RA,Ashton HA,Thompson SG,Multicentre Aneurysm Screening Study Group.

更新日期：2007-05-15 00:00:00