解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Embryonic tissue expresses a very low level of MHC molecules, and these few appear only late in ontogeny. Possibly related are deficiencies in the expression of TAP molecules and also the fetus' need to avoid maternal immunologic rejection. However, the fetus may overcome the lack of Ag-presenting molecules when threa...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939709008021
更新日期:1997-01-01 00:00:00
abstract::IL-6 is a paracrine and autocrine cytokine, which acts in the regulation of immunological and inflammatory processes. Its production can be observed in different cell types, as well as thyrocytes. The purpose of the study was to examine the serum IL-6 levels between the patients with Graves' disease (N = 47) and witho...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939708996275
更新日期:1997-01-01 00:00:00
abstract::Subcutaneous insulin treatment of young diabetes prone BB rats has been shown previously to suppress the development of autoimmune diabetes. In this study the hypothesis was tested that exogenous insulin may deviate the autoimmune process by acting on the Th1/Th2 cytokine balance in the pancreas. BB rats were implante...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939709009544
更新日期:1997-01-01 00:00:00
abstract::Linomide (quinoline-3-carboxamide), a well tolerated, orally administered compound was recently shown to be effective in the prevention and treatment of several autoimmune diseases in experimental animal models. We have investigated its effect on specific humoral immune responses directed to T-cell-dependent soluble o...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939708994731
更新日期:1997-01-01 00:00:00
abstract::Murine monoclonal antibodies (mAb) produced against native human thyroid peroxidase (TPO) are powerful tools for analyzing the autoantibody (Aab) epitopes on TPO. Binding sites of thirteen mAbs cover all or most antigenic regions on TPO. We determined the competition between Aabs from 75 AITD patients and 13 mAbs in b...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995338
更新日期:1996-01-01 00:00:00
abstract::A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among al...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608994714
更新日期:1996-01-01 00:00:00
abstract::Autoantigen-reactive T lymphocytes have been implicated in the pathogenesis organ-specific autoimmune disease. Thyroglobulin (Tg) is one of the primary autoantigens associated with autoimmune lymphocytic thyroiditis (LT). These experiments investigated the pathogenicity of a lymphocyte line derived from spontaneously-...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995327
更新日期:1996-01-01 00:00:00
abstract::Integrin-adressin binding is a critical step in lymphocte attachment to target tissues. The mucosal recognition systems (alpha E beta 7, alpha 4 beta 7, MADcam-1) have been implicated in the autoimmune process in rheumatoid arthritis. We developed a model for in vivo study of radio-labelled lymphocyte circulation and ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995363
更新日期:1996-01-01 00:00:00
abstract::CD4+ T cells play a crucial role in the development of lupus in MRL-lpr/lpr mice: incomplete deletion/silencing of self-reactive CD4+ T cells leads to T cell activation, which causes both polyclonal B cell activation and T cell infiltration of multiple organs. Furthermore, anti-CD4 antibody therapy ameliorates disease...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995346
更新日期:1996-01-01 00:00:00
abstract::The MRL/lpr model of SLE resembles human lupus in its various immunopathologic characteristics including the presence of high-level IgG and anti-DNA antibody production and multisystem organ involvement (nephritis, arthritis, and vasculitis). Our previous studies have shown that IL-1 overactivity in B cells plays a po...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939609001949
更新日期:1996-01-01 00:00:00
abstract::The present study investigated the expressed number of CR1 on erythrocytes (E) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus (SLE) and 47 healthy volunteers. The CR1 genotype was determined by a method based on polymerase chain reaction (PCR) amplification of the genomi...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608994726
更新日期:1996-01-01 00:00:00
abstract::Agalactosyl IgG (Gal(0) is a glycoform lacking terminal galactose from the oligosaccharides situated on the Fc. The percentage of circulating IgG that is Gal(0) is increased in a a number of autoimmune diseases, and in certain chronic infections associated with autoantibody production. However it is not known whether ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508995306
更新日期:1995-01-01 00:00:00
abstract::Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and convers...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508995297
更新日期:1995-01-01 00:00:00
abstract::Previous studies directed towards identifying epitopes on type II collagen (CII) important in collagen induced arthritis (CIA) in mice have focused primarily on responses mounted in susceptible H-2q strains. However, the nature of T and B cell responses against CII in susceptible H-2r strains remains ill-defined. In a...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508993338
更新日期:1995-01-01 00:00:00
abstract::An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939509001938
更新日期:1995-01-01 00:00:00
abstract::We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508993350
更新日期:1995-01-01 00:00:00
abstract::Antiphospholipid antibodies (aPLA) were discovered during the course of Mediterranean spotted fever (MSF) caused by Rickettsia conorii and characterized by endothelial cell (EC) damage resulting from this organism's tropism for EC. In two MSF patients, two types of aPLA were identified: antiphosphatidylethanolamine an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508993359
更新日期:1995-01-01 00:00:00
abstract::We report in this paper on obvious fibrotic lesions in the liver of mice undergoing specified graft-versus-host reaction (GVHR). B6 CD8+ splenocytes were transferred into (bm 12 x bm 1)F1 mice to induce GVHR. Recipient mice had been thymectomized and administrated with anti-CD8 monoclonal antibody (mAb) to deplete CD8...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508995313
更新日期:1995-01-01 00:00:00
abstract::Six different hybridomas secreting anti-SCM mAb and one control mAb were placed into adult mice along with [14C] amino acids for biosynthetically labeling. After sacrifice, the 14C mAb ascites along with serum, heart, kidney, lung and skeletal muscle were recovered. Tissue associated specific radio-activity (SpAc) and...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939408995693
更新日期:1994-01-01 00:00:00
abstract::Non obese diabetic (NOD) mice spontaneously develop thyroiditis in addition to diabetes. Mononuclear cells begin to infiltrate the thyroid of these animals in the first month of life. The expression of major histocompatibility complex (MHC) class II (Ia) antigens by cells in the thyroid from NOD mice of various ages w...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409014653
更新日期:1994-01-01 00:00:00
abstract::We have used the reverse transcriptase polymerase chain reaction (RT-PCR) technique to assess the expression of cytokine genes in various T cell subsets of autoimmune-prone mice. Our study confirmed the previously described features in lpr mice that IFN-gamma, TNF-alpha, and TNF-beta were transcribed by various T cell...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409014658
更新日期:1994-01-01 00:00:00
abstract::Thyroid lymphocyte RNA from a Hashimoto patient with high serum levels of autoantibodies to thyroid peroxidase (TPO) was used to construct a phage display antibody library in the phagemid vector pComb3. The library (100,000cfu) encoded IgG1 heavy chains together with kappa light chains. Selection of the phages display...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409010651
更新日期:1994-01-01 00:00:00
abstract::The nonobese diabetic (NOD) mouse develops diabetes spontaneously due to autoimmune destruction of the pancreatic islets with a higher incidence in the female than the male. Prolactin (PRL), a hormone whose role has been previously focused on reproduction and lactation has been demonstrated to influence immune respons...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409007991
更新日期:1994-01-01 00:00:00
abstract::This study was undertaken to determine whether the expression of 17.109, 6B6.6 and 4C9 rheumatoid factor (RF) idiotypes is predictive of the development of rheumatoid arthritis (RA) and whether the RF response is idiotypically restricted in an inbred population of Pima Indians who have a genetic predisposition for the...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409009526
更新日期:1994-01-01 00:00:00
abstract::We reported a patient who gave birth to 3 children with transient neonatal hypothyroidism. She had 3 different antibodies (Ab) to the thyrotropin receptor (TSHR) in her serum, viz., TSH binding-inhibiting (TBIAb), thyroid-stimulating (TSAb) and an additional stimulating Ab (SAb). The SAb differed from TSAb in that its...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409008006
更新日期:1994-01-01 00:00:00
abstract::Interleukin (IL)-1 inhibits the function of insulin-producing rat pancreatic beta-cells in vitro and in vivo, and it has been postulated that the IL-1 effect is mediated through the cytokine inducible nitric oxide (NO) synthase. IL-1 inhibits the function of cultured human thyroid cells too, and in this study human th...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409071349
更新日期:1994-01-01 00:00:00
abstract::It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409009538
更新日期:1994-01-01 00:00:00
abstract::It has been suggested that pancreatic beta-cell destruction occurring during the process leading to insulin-dependent diabetes mellitus (IDDM) involves formation of nitric oxide (NO). We have presently studied the effect of aminoguanidine (AG), which has recently been reported to inhibit generation of NO induced by th...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309115754
更新日期:1993-01-01 00:00:00
abstract::Experimental autoimmune myocarditis could be produced in mice by repeated injection of syngeneic heart extract together with Klebsiella pneumoniae O3 lipopolysaccharide (KO3 LPS) as a powerful adjuvant. Histological changes in the cardiac lesions were characterized by infiltration with mononuclear cells in the myocard...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309077370
更新日期:1993-01-01 00:00:00
abstract::Congenic B10.BR/SgSnJ H-2kTlaa mice were infected with a diabetogenic strain of coxsackievirus CB4 to correlate abnormalities of sugar metabolism with virus replication in islets, 64,000-M(r) (64K) islet autoantigen expression, 64K antibody development, and pancreas histopathology in early and late infection. Plaque a...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309077366
更新日期:1993-01-01 00:00:00
abstract::We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309079229
更新日期:1993-01-01 00:00:00
abstract::We have used the MRL/lpr murine model of spontaneous lupus to investigate three questions in infection immunity: (1) does mycobacterial infection have any effect on the mortality of the autoimmunity-prone lpr mice?; (2) does the infection modify the progression of kidney disease of lpr lupus?; and (3) does the lpr gen...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939308993323
更新日期:1993-01-01 00:00:00
abstract::Although a variety of eye muscle antigens are recognized by autoantibodies in the serum from patients with thyroid associated ophthalmopathy (TAO) 64 kDa membrane proteins, which are also expressed in the thyroid, are most closely linked to the development of ophthalmopathy in patients with autoimmune thyroid disease....
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939308993314
更新日期:1993-01-01 00:00:00
abstract::Experimental myasthenia gravis (EMG) was elicited in female AO rats, 8-12 weeks of age, by injection of 100 micrograms/rat Torpedo marmorata acetylcholine receptor (AChR)-protein incorporated in CFA. Bordetella pertussis, 24 x 10(9) microorganisms, rat, was injected simultaneously as additional adjuvant. Rats were sac...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309019928
更新日期:1993-01-01 00:00:00
abstract::Evidence is growing that autoimmune reactivity results from a combination of endogenous (e.g. MHC type) and environmental factors. Our experimental study focuses on the induction of autoimmune reactivity by microbial factors. Splenic formation and serum levels of anti-erythrocyte antibodies and circulating immune comp...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309004838
更新日期:1993-01-01 00:00:00
abstract::Macrophages from autoimmune diabetes prone BB rats were found to produce radical oxygen intermediates (ROI) at an enhanced rate when compared to diabetes resistant BB or normal Wistar rats. The release of ROI was determined by chemiluminescence using in parallel luminol and lucigenin as detector molecules. In diabetes...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309043883
更新日期:1993-01-01 00:00:00
abstract::Glycosaminoglycan (GAG) accumulation in the retrobulbar space of patients with thyroid-associated ophthalmopathy (TAO) has been documented in a number of immunohistochemical studies. In order to gain further insight into possible immunopathogenic mechanisms, the influence of humoral immunity on retrobulbar fibroblasts...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939209014639
更新日期:1992-01-01 00:00:00
abstract::Five separate monoclonal antibodies (MoAbs) to human thyroid peroxidase (hTPO) were raised by immunising Balb/c mice with hTPO purified from detergent solubilised thyroid microsomes by high performance liquid chromatography (HPLC). The epitope specificities of these MoAbs were determined by assessing their ability to ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209035148
更新日期:1992-01-01 00:00:00
abstract::The presence of autoantibodies (aAbs) to thyroglobulin (TG) and thyroperoxidase (TPO) in most of the patients with autoimmune thyroid disease is now well documented. Studies of these aAbs suggested that some, termed TGPO aAbs, could interact with both TG and TPO. This hypothesis was investigated using IgG fraction fro...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209035153
更新日期:1992-01-01 00:00:00
abstract::Autoantibodies against the beta-cell M(r) 64,000 protein (p64), recently identified as an isoform of glutamic acid decarboxylase (GAD), are prevalent in patients with insulin-dependent diabetes mellitus (IDDM). Dog islets were found to represent an abundant source of native p64 allowing the study of antigen-antibody i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209004823
更新日期:1992-01-01 00:00:00