abstract：BACKGROUND:Transcranial magnetic stimulation (TMS) is a relatively novel, noninvasive method of altering cerebral electrophysiological activity that produces localized and reversible changes in brain tissue. TMS has been shown to have antidepressant properties in both human trials and animal models. Additionally, TMS m...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hedges DW,Massari C,Salyer DL,Lund TD,Hellewell JL,Johnson AC,Lephart ED

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:The aim of the study was to compare the activity of gonadal hormones and serotonergic system in premenopausal women with or without depression in relation to clinical and hormonal indices of menopause. METHODS:The sample included 60 women with single or recurrent major depressive episode with disease onset aft...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rajewska J,Rybakowski JK

更新日期：2003-06-01 00:00:00

abstract：:Retinoic acid-induced differentiation of SH-SY5Y human neuroblastoma cells results in the development of extensive neurite processes as well as changes in cell body morphology toward a neuronal phenotype. The authors have examined concurrent regulation of beta-amyloid precursor protein (APP) and inositol 1,4,5-trispho...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Murray JN,Igwe OJ

更新日期：2003-05-01 00:00:00

abstract：:There is a vast literature examining the neurochemical effects of anxiolytics throughout the rat brain; however, although the behavioural actions of anxiolytic drugs are routinely assessed in animal models of anxiety, the majority of neurochemical studies have been performed in rats with relatively 'normal' behavioura...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lodge DJ,Lawrence AJ

更新日期：2003-05-01 00:00:00

abstract：:The effects of the cytochrome P450 (CYP)2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam were studied in 16 healthy male volunteers. The two mutated alleles (CYP2C19*2 and CYP2C19*3) causing absent CYP2C19 activity were identified by PCR-based restriction e...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Aoshima T,Fukasawa T,Otsuji Y,Okuyama N,Gerstenberg G,Miura M,Ohkubo T,Sugawara K,Otani K

更新日期：2003-05-01 00:00:00

abstract：:Apoptosis is a form of programmed cell death that results in the orderly and efficient removal of damaged or unnecessary cells, such as those resulting from DNA damage or during development. There are many factors that contribute to this process, each demonstrating specificity of function, regulation, and pathway invo...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ashe PC,Berry MD

更新日期：2003-04-01 00:00:00

abstract：:The biochemical and physiological processes involved in apoptosis were described from the perspective of detection by standard, clinical, noninvasive imaging modalities. The difficulties of monitoring apoptosis in vivo were discussed. Magnetic resonance imaging (MRI) approaches used to study apoptosis were surveyed. T...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Brauer M

更新日期：2003-04-01 00:00:00

abstract：:The effects of repeated antidepressant drug treatment on behavioral outcome in Wistar Kyoto (WKY) rats, a putative animal model of depressive behavior, were compared to Wistar and Sprague-Dawley (SD) rats. Rats were treated with desipramine (norepinephrine [NE] uptake blocker), nomifensine (NE and dopamine [DA] uptake...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Tejani-Butt S,Kluczynski J,Paré WP

更新日期：2003-02-01 00:00:00

abstract：:The selective serotonin reuptake inhibitors (SSRIs) have emerged as a major therapeutic advance in psychopharmacology. As a result, the discovery of these agents marks a milestone in neuropsychopharmacology and rational drug design, and has launched a new era in psychotropic drug development. Prior to the SSRIs, all p...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Vaswani M,Linda FK,Ramesh S

更新日期：2003-02-01 00:00:00

abstract：:Even though 85% of adults drink caffeinated beverages daily, very limited studies on plasma caffeine concentration in the US population have been published. Smoking induces cytochrome P450 1A2 (CYP1A2), which is the main enzyme involved in caffeine metabolism. The current naturalistic pilot study explores plasma caffe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： de Leon J,Diaz FJ,Rogers T,Browne D,Dinsmore L,Ghosheh OH,Dwoskin LP,Crooks PA

更新日期：2003-02-01 00:00:00

abstract：:The authors report on five patients who first developed Tourette's syndrome (TS) and later schizophrenia with the typical positive and negative symptoms; all five had an unfavorable course of schizophrenia. These observations as well as other reported cases raise the question of whether both disorders may share a comm...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Müller N,Riedel M,Zawta P,Günther W,Straube A

更新日期：2002-12-01 00:00:00

abstract：:The influence of 20 min global cerebral ischemia on the free arachidonic acid (FAA) level and Na+,K+-ATPase activity in the rat hippocampus at different time points after ischemia was examined. In addition, the effect of MK-801 on mentioned parameters was studied. Animals were exposed to 20 min global cerebral ischemi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Mrsić-Pelcić J,Zupan G,Maysinger D,Pelcić G,Vitezić D,Simonić A

更新日期：2002-12-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that autism (a neurodevelopmental disorder of unknown etiology) is associated with altered phospholipid-related signal transduction using the niacin skin flush test. This is the first reported use of this test in this disorder. The response to topical aqueous methyl nic...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Puri BK,Singh I

更新日期：2002-12-01 00:00:00

abstract：:The effects of fencamfamine (FCF), an indirect dopamine (DA) agent, were investigated using the latent inhibition (LI) model of schizophrenia. In the LI procedure, rats preexposed (PE) to an unreinforced stimulus show difficulty in subsequent learning of an association in which that stimulus is predictive of an uncond...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Alves CR,Delucia R,Silva MT

更新日期：2002-10-01 00:00:00

abstract：:Zolpidem is a rapid-onset, short-duration, quickly eliminated imidazopyridine hypnotic. It has been suggested that zolpidem may produce less memory and cognitive impairment than benzodiazepines (BZs) due to its low binding affinity for BZ receptor subtypes found in areas of the brain that are involved in learning and ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Akhondzadeh S,Mohammadi MR,Kashani L

更新日期：2002-10-01 00:00:00

abstract：:The purpose of this cross-sectional study was to examine the relationships between neurocognitive deficits and quality of life for patient with schizophrenia. Fifty-seven schizophrenic outpatients (38 men and 19 women) were assessed for neurocognitive deficits using the Wisconsin Card Sorting Test (WCST) and all patie...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Aksaray G,Oflu S,Kaptanoğlu C,Bal C

更新日期：2002-10-01 00:00:00

abstract：:The prefrontal temporal cortical network (PFTCN) is a crucial part of a widely distributed neural network which has been shown (a) to subserve language function; (b) to modulate the cognitive circuits that are linked with work production; and (c) to organise thinking and develop word-search strategies. Dysfunction of ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dursun SM,Robertson HA,Bird D,Kutcher D,Kutcher SP

更新日期：2002-06-01 00:00:00

abstract：:The aim of the present study was to develop an animal model for the study of depressive symptoms associated with Parkinson's disease (PD). Mice treated intraperitoneally with reserpine (RES), 2.0 and 1.0 mg/kg, or its vehicle (VEHIC) were submitted to the sucrose solution (2%) consumption test (a model employed to mim...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Skalisz LL,Beijamini V,Joca SL,Vital MA,Da Cunha C,Andreatini R

更新日期：2002-06-01 00:00:00

abstract：:The aim of the present study was to compare the possible dependence potential of antidepressants (ADs) to benzodiazepines (BZDs). The Schedules for Clinical Assessment in Neuropsychiatry (SCAN), the Benzodiazepine Dependence Self-Report Questionnaire (Bendep-SRQ) and the Symptom Checklist-90 (SCL-90) were administered...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： van Broekhoven F,Kan CC,Zitman FG

更新日期：2002-06-01 00:00:00

abstract：:The aim of the research was to select some easily available and easily replicable biological markers that could be used as predictors of both acute and long-term therapy. A selection of state markers (structural computer tomography [CT] parameters, psychological parameters, tests concentrating on attention and memory,...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Cesková E,Drybcák P,Lorenc M

更新日期：2002-05-01 00:00:00

abstract：:The Delusional Misidentification Syndrome (DMS) is thought to be related to dissociation between recognition and identification processes. Working memory (WM) is considered responsible for the integration and online manipulation of information, so that it is available for further processing. Since the P300 component o...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Papageorgiou C,Lykouras L,Ventouras E,Uzunoglu N,Christodoulou GN

更新日期：2002-05-01 00:00:00

abstract：:Motor symptoms including neurological soft signs have been found to be more prevalent in schizophrenic patients. In addition, catatonic symptoms and neuroleptic treatment as well may influence cortical and subcortical motor organization in schizophrenia. The results of previous neuroimaging studies exploring motor fun...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Müller JL,Röder CH,Schuierer G,Klein H

更新日期：2002-04-01 00:00:00

abstract：:Latent inhibition (LI) is a behavioural paradigm in which repeated exposure to a stimulus without consequence inhibits the formation of any new associations with that stimulus. To the extent that LI reflects a process of leaming to ignore irrelevant stimuli, disrupted LI has been suggested as an animal model for the a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gracey DJ,Bell R,King DJ

更新日期：2002-04-01 00:00:00

abstract：:The antipsychotic drug, bromperidol, is a close structural analogue of haloperidol. These two drugs also have similarities in metabolic pathways and pharmacological properties. In the present study, the prolactin concentrations in plasma during bromperidol versus haloperidol treatments were compared in the same indivi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yasui-Furukori N,Kondo T,Suzuki A,Mihara K,Kaneko S,Otani K

更新日期：2002-04-01 00:00:00

abstract：:Schizophrenic patients have problems with saccadic eye movements that can be characterized as a loss of control over the saccadic system. Preliminary clinical results suggest that antipsychotics can either disrupt or improve saccadic performance. The brain mechanism through which antipsychotics might affect saccades i...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Broerse A,Timmerman W,Westerink BH,Den Boer JA

更新日期：2002-02-01 00:00:00

abstract：:Effects of the nitric oxide synthase (NOS) inhibitors 7-nitroindazole (7-NI), N(G)-nitro-L-arginine (L-NOARG) and N(G)-nitro-L-arginine methyl ester (L-NAME) on the behaviour of control and small-platform (SP)-stressed mice in the plus-maze test were studied. SP stress was induced by placing mice on SPs (3.5 cm diamet...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pokk P,Väli M

更新日期：2002-02-01 00:00:00

abstract：:The effect exerted by two beta-endorphin fragments (DTgammaE and DEgammaE) was investigated on the acute opioid dependence induced by mu, kappa and delta receptor agonists in vitro. After a 4-min in vitro exposure to morphine (less selective mu agonist), DAGO (highly selective mu agonist), U50-488H (highly selective k...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Capasso A,Loizzo A

更新日期：2002-02-01 00:00:00

abstract：:A single male subject with hyperuricosuric autism was treated for a period of 2 years with an oral dose of uridine, which increased from 50 to 500 mg/kg/day. This patient experienced dramatic social, cognitive, language, and motor improvements. These improvement decreased within 72 h of the discontinuation of uridine,...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Page T,Moseley C

更新日期：2002-02-01 00:00:00

abstract：:The effect of electrical vagus nerve stimulation (VNS) on sleep and behavior was analyzed in freely moving cats. Eight cats were prepared for 23-h sleep recordings. The left vagus nerve of four of them was stimulated during 1 min, five times at 1-h intervals, for 5 days. The VNS induces: ipsilateral myosis, blinking, ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Valdés-Cruz A,Magdaleno-Madrigal VM,Martínez-Vargas D,Fernández-Mas R,Almazán-Alvarado S,Martínez A,Fernández-Guardiola A

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:With the increasing number and type of antidepressants available to clinicians, there is a need to better understand current prescribing practices and to what degree these practices reflect research findings. The purpose of this study was to examine prescribing practices in a sample of psychiatrists attendin...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Petersen T,Dording C,Neault NB,Kornbluh R,Alpert JE,Nierenberg AA,Rosenbaum JF,Fava M

更新日期：2002-01-01 00:00:00

abstract：:Cocaine is a common drug of abuse, and its use has emerged as a major public health problem with neurological complications. In this work, the authors studied microscopic lesions produced in brain by chronic cocaine administration to rats. Twenty-five Wistar rats were exposed to 30 mg/kg/day ip of cocaine and sacrific...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Barroso-Moguel R,Mendez-Armenta M,Villeda-Hernandez J,Nava-Ruiz C,Santamaria A

更新日期：2002-01-01 00:00:00

abstract：:1. The effect of gender, smoking and pubertal development on platelet monoamine oxidase (MAO) activity was described in a randomly selected, large sample of 9- and 15-years old healthy children. 2. Platelet MAO activity was measured in 1129 children by a radioenzymatic method with beta-phenylethylamine as the substrat...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Harro M,Eensoo D,Kiive E,Merenäkk L,Alep J,Oreland L,Harro J

更新日期：2001-11-01 00:00:00

abstract：:1. Disruption of calcium homeostasis during neurodegenerative diseases is known to trigger apoptotic or necrotic death in neuronal cells. Recently, the authors reported that intracellular calcium restriction by NMDA receptor antagonists induces apoptosis in cortical cultures. To evaluate whether further restriction of...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wie MB,Koh JY,Won MH,Lee JC,Shin TK,Moon CJ,Ha HJ,Park SM,Kim HC

更新日期：2001-11-01 00:00:00

abstract：:In the brains of patients with Alzheimer's disease (AD) signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes to the pathogenesis of the disease. A d...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Allison AC,Cacabelos R,Lombardi VR,Alvarez XA,Vigo C

更新日期：2001-10-01 00:00:00

abstract：:Social anxiety disorder is a common illness with significant associated disability. Serotonin selective reuptake inhibitors (SSRIs) have become first-line treatment given their improved tolerability; however, there are few reports on the use of citalopram. Nine consecutive patients with a primary diagnosis of DSM-IV g...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Simon NM,Sharma SG,Worthington JJ,Marzol PC,Pollack MH

更新日期：2001-10-01 00:00:00

abstract：:1. Recent developments in technologies permit systematic screening of the entire human genome as a strategy for identification of susceptibility genes of small effect that influence risk to complex traits, like schizophrenia (Schz), inflammatory bowel disease, bipolar affective disorder (BPAD) etc. 2. Schizophrenia is...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Vaswani M,Kapur S

更新日期：2001-08-01 00:00:00

abstract：:1. Isolation-reared rats display fear-like behavior and depressive-like behavior in several behavioral tasks, suggesting that isolation rearing may model certain aspects of human psychopathologies. 2. After weaning (20 days old), male and female Wistar rats were isolation-reared during 20, 50 or 70 days. After that, t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Molina-Hernandez M,Tellez-Alcantara P,Perez-Garcia J

更新日期：2001-07-01 00:00:00

abstract：:Despite considerable efforts and successes investigating the function of the hippocampal formation in memory processes, there are still numerous elusive key issues. Some of them will be addressed in this review. We will argue that recent evidence supports hippocampal participation in several memory processes, such as ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Riedel G,Micheau J

更新日期：2001-05-01 00:00:00

abstract：:1. The available evidence suggests that stress induced release of acetylcholine (ACh) in the brain has a significant role in mediating neuroendocrine, emotional, and physiological responses to stress. Recent findings also suggest that stress indirectly (via acetylcholine) and nicotine directly stimulates the HPA axis ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Newman MB,Nazian SJ,Sanberg PR,Diamond DM,Shytle RD

更新日期：2001-04-01 00:00:00

abstract：:1. This study examines the relation between baseline clinical characteristics in patients with posttraumatic stress disorder (PTSD) and response to treatment with a reversible monoamine oxidase A inhibitor (RIMA), brofaromine. 2. Data from two comparable, double-blind, placebo-controlled studies of brofaromine in pati...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Connor KM,Hidalgo RB,Crockett B,Malik M,Katz RJ,Davidson JR

更新日期：2001-02-01 00:00:00