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Brain lesions induced by chronic cocaine administration to rats.

Abstract：

:Cocaine is a common drug of abuse, and its use has emerged as a major public health problem with neurological complications. In this work, the authors studied microscopic lesions produced in brain by chronic cocaine administration to rats. Twenty-five Wistar rats were exposed to 30 mg/kg/day ip of cocaine and sacrificed at 15, 30, 45, 60, and 90 days after treatment and compared to 25 control rats injected daily with saline. The parietal cortex (Cx), hippocampus (Hp), substantia nigra (SN), and cerebellum (Ce) were morphologically analyzed. The authors found progressive light microscopic lesions in all regions studied, including nuclear pyknosis and atrophy, interstitial edema, broken fibers, and necrosis. Results show that chronic treatment with cocaine in rats leads to selective severe lesions in different brain regions.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Barroso-Moguel R,Mendez-Armenta M,Villeda-Hernandez J,Nava-Ruiz C,Santamaria A

doi

10.1016/s0278-5846(01)00229-9

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

59-63

issue

1

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(01)00229-9

journal_volume

26

pub_type

杂志文章

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