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Adverse childhood experiences associate to reduced glutamate levels in the hippocampus of patients affected by mood disorders.

Abstract：

:Adverse childhood experiences (ACE) can possibly permanently alter the stress response system, affect the glutamatergic system and influence hippocampal volume in mood disorders. The aim of the study is to investigate the association between glutamate levels in the hippocampus, measured through single proton magnetic resonance spectroscopy (1H-MRS), and ACE in patients affected by mood disorders and healthy controls. Higher levels of early stress associate to reduced levels of Glx/Cr in the hippocampus in depressed patients but not in healthy controls. Exposure to stress during early life could lead to a hypofunctionality of the glutamatergic system in the hippocampus of depressed patients. Abnormalities of glutamatergic signaling could then possibly underpin the structural and functional abnormalities observed in patients affected by mood disorders.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Poletti S,Locatelli C,Falini A,Colombo C,Benedetti F

doi

10.1016/j.pnpbp.2016.07.007

subject

Has Abstract

pub_date

2016-11-03 00:00:00

pages

117-22

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(16)30112-9

journal_volume

71

pub_type

杂志文章

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