当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Functional brain imaging and pharmacotherapy in social phobia: single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram.

Functional brain imaging and pharmacotherapy in social phobia: single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram.

Abstract：

:1. Despite increased understanding of the prevalence and pharmacotherapy of social phobia (or social anxiety disorder), the neurobiology of the disorder is little understood. 2. Little data exists on the effect of pharmacotherapeutic intervention on regional cerebral blood flow (rCBF) in this disorder. Patients (n=15) who met DSM-IV diagnostic criteria for social phobia were subjected to single photon emission computed tomography (SPECT) with technetium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO) before and after an eight-week trial of pharmacotherapy with the selective serotonin reuptake inhibitor (SSRI) citalopram. 3. Pharmacotherapy led to significantly reduced activity in the anterior and lateral part of the left temporal cortex; the anterior, lateral and posterior part of the left mid frontal cortex; and the left cingulum. 4. Despite the small sample size, medication non-responders (n=6) had higher activity at baseline in the anterior and lateral part of the left temporal cortex and the lateral part of the left mid frontal regions compared with responders (n=9). These data from this exploratory study are consistent with work suggesting that the anxiety disorders share certain mediating neurocircuitry, although activity in other brain regions may differ. 5. Further research is necessary to determine the neurobiological underpinnings of social phobia.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Van der Linden G,van Heerden B,Warwick J,Wessels C,van Kradenburg J,Zungu-Dirwayi N,Stein DJ

doi

10.1016/s0278-5846(99)00109-8

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

419-38

issue

3

eissn

0278-5846

issn

1878-4216

pii

S0278584699001098

journal_volume

24

pub_type

临床试验,杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Vglut2 haploinsufficiency enhances behavioral sensitivity to MK-801 and amphetamine in mice.

    abstract：:Recently developed mouse models have implicated the vesicular glutamate transporter 2 (VGLUT2) in psychostimulant-induced hyperactivity, a behavioral assay that is often applied to evaluate mouse behavior related to positive schizophrenia (SCZ) symptomatology. In present research, we wanted to evaluate further the rol...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.03.023

    authors： Naert A,Callaerts-Vegh Z,Moechars D,Meert T,D'Hooge R

    更新日期：2011-07-01 00:00:00

  • Metabolic treatment of hyperuricosuric autism.

    abstract：:A single male subject with hyperuricosuric autism was treated for a period of 2 years with an oral dose of uridine, which increased from 50 to 500 mg/kg/day. This patient experienced dramatic social, cognitive, language, and motor improvements. These improvement decreased within 72 h of the discontinuation of uridine,...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(01)00249-4

    authors： Page T,Moseley C

    更新日期：2002-02-01 00:00:00

  • Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus.

    abstract：:Synaptic dysfunction has recently gained attention for its involvement in mood disorders. Electroconvulsive therapy (ECT) possibly plays a role in synaptic repair. However, the underlying mechanisms remain uncertain. Thrombospondin-1 (TSP-1), a member of the TSP family, is reported to be secreted by astrocytes and to ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2013.10.001

    authors： Okada-Tsuchioka M,Segawa M,Kajitani N,Hisaoka-Nakashima K,Shibasaki C,Morinobu S,Takebayashi M

    更新日期：2014-01-03 00:00:00

  • Regional homogeneity of resting-state brain abnormalities in bipolar and unipolar depression.

    abstract：OBJECTIVE:Bipolar disorder patients experiencing a depressive episode (BD-dep) without an observed history of mania are often misdiagnosed and are consequently treated as having unipolar depression (UD), leading to inadequate treatment and poor outcomes. An essential solution to this problem is to identify objective bi...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.11.010

    authors： Liu CH,Ma X,Wu X,Zhang Y,Zhou FC,Li F,Tie CL,Dong J,Wang YJ,Yang Z,Wang CY

    更新日期：2013-03-05 00:00:00

  • Effects of chronic nicotine on the temporal structure of anxiety-related behavior in rats tested in hole-board.

    abstract：:The present study aimed to assess the behavioral effects of chronic treatments of different doses of nicotine by using both quantitative and multivariate T-pattern analysis (TPA), which can reveal hidden behavioral structures, in Sprague-Dawley rats tested in the hole-board apparatus. To this purpose, nicotine ditartr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109731

    authors： Casarrubea M,Pierucci M,Aiello S,Cassar D,Deidda G,Crescimanno G,Di Giovanni G

    更新日期：2020-01-10 00:00:00

  • Neural correlates during working memory processing in major depressive disorder.

    abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) studies in major depressive disorder (MDD) have revealed cortical-limbic-subcortical dysfunctions during working memory (WM) processing, but the results are inconsistent and it is unclear to what extent these findings are influenced by demographic, clinical charac...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2014.08.011

    authors： Wang XL,Du MY,Chen TL,Chen ZQ,Huang XQ,Luo Y,Zhao YJ,Kumar P,Gong QY

    更新日期：2015-01-02 00:00:00

  • Replication of previous GWAS hits suggests the association between rs4307059 near MSNP1AS and autism in a Chinese Han population.

    abstract：:Autism is a complex neurodevelopmental disorder with high heritability. Previous genome-wide association studies (GWAS) demonstrated that some single-nucleotide polymorphisms (SNPs) were significantly associated with autism, while other studies focusing on these GWAS hits showed inconsistent results. Besides, the asso...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.12.016

    authors： Wang Z,Zhang J,Lu T,Zhang T,Jia M,Ruan Y,Zhang D,Li J,Wang L

    更新日期：2019-06-08 00:00:00

  • Acute and chronic tianeptine treatments attenuate ethanol withdrawal syndrome in rats.

    abstract：:Effects of acute and chronic tianeptine treatments on ethanol withdrawal syndrome were investigated in rats. Ethanol (7.2% v/v) was given to adult male Wistar rats by a liquid diet for 30 days. Acute or chronic (twice daily) tianeptine (5, 10 and 20 mg/kg) and saline were administered to rats intraperitoneally. Acute ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2005.11.013

    authors： Uzbay T,Kayir H,Celik T,Yüksel N

    更新日期：2006-05-01 00:00:00

  • Propranolol in schizophrenia.

    abstract：:1. 15 schizophrenic patients diagnosed according to criteria of I.C.D.-9 were treated with d1-propranolol in a 4 week open study. 2. A fixed dose schedule was followed and a maximum dose of 1920 mg/day was reached by day 17. 3. Results revealed a significant reduction in core schizophrenic symptoms of CPRS & BPRS star...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90093-3

    authors： Sethi BB,Dubé S

    更新日期：1983-01-01 00:00:00

  • A review of epidemiological evidence for general anesthesia as a risk factor for Alzheimer's disease.

    abstract：:Exposure to surgery and general anesthesia (GA) has been hypothesized to be a potential risk factor for the development of Alzheimer's disease (AD). Some basic science research studies have demonstrated AD pathology in animals following exposure to inhalational anesthetics. However, controversy exists as to whether GA...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2012.06.022

    authors： Seitz DP,Reimer CL,Siddiqui N

    更新日期：2013-12-02 00:00:00

  • Disturbances in acute phase plasma proteins during melancholia: additional evidence for the presence of an inflammatory process during that illness.

    abstract：:1. Leukocyte enumeration through flow cytometry has revealed that severe depression may be accompanied by a systemic immune activation, indicative of an inflammatory response. The latter condition allegedly involves an important modification of acute phase plasma protein (APP) equilibrium. 2. In order to elucidate whe...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(92)90056-k

    authors： Maes M,Scharpe S,Bosmans E,Vandewoude M,Suy E,Uyttenbroeck W,Cooreman W,Vandervorst C,Raus J

    更新日期：1992-07-01 00:00:00

  • Novel therapeutic targets in mood disorders: Pentoxifylline (PTX) as a candidate treatment.

    abstract：:Numerous pharmacological treatments for mood disorders are currently available; however, rates of treatment resistance, relapse and recurrence remain high. Therefore, novel treatments acting outside of the conventionally targeted monoamine system are urgently needed to improve patient outcomes. Emerging and converging...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2020.110032

    authors： Siegel AN,Rodrigues N,Nasri F,Wilkialis L,Lipsitz O,Lee Y,Gill H,Subramaniapillai M,Phan L,Majeed A,Lui LMW,Rashidian H,Ho R,Toma S,Goldstein BI,Mansur RB,McIntyre RS,Rosenblat JD

    更新日期：2021-01-10 00:00:00

  • RBC-choline: a biological marker of the outcome of lithium prophylaxis?

    abstract：:We explored whether the elevation of RBC-choline and choline ratio (RBC-choline/plasma-choline) by lithium is a specific effect of lithium, whether these choline parameters are characteristics of the individual patient, and whether they are related to prophylactic lithium response. In lithium-treated patients RBC-chol...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(87)90062-5

    authors： Haag M,Granzow L,Greil W,Haag H

    更新日期：1987-01-01 00:00:00

  • Neural substrates for late-life depression: A selective review of structural neuroimaging studies.

    abstract：:Recent neuroimaging studies have characterized the pathophysiology of late-life depression (LLD) as a dysfunction of the brain networks involved in the regulation of emotion, motivational behavior, cognitive control, executive function, and self-referential thinking. In this article, we reviewed LLD-associated structu...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2020.110010

    authors： Kim YK,Han KM

    更新日期：2021-01-10 00:00:00

  • Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia.

    abstract：OBJECTIVE:Recently, traditional herbal medicines have been reported to be effective for behavioral and psychological symptoms of dementia (BPSD). This study aims to examine the efficacy of Yi-Gan San (YGS) in the improvement of BPSD and sleep disorders in patients with dementia. METHODS:Five patients (1 male and 4 fem...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2007.12.027

    authors： Shinno H,Inami Y,Inagaki T,Nakamura Y,Horiguchi J

    更新日期：2008-04-01 00:00:00

  • Accelerated apoptosis of blood leukocytes and oxidative stress in blood of patients with major depression.

    abstract：:Acceleration of blood leukocyte apoptosis in major depression has been described. The present studies have been undertaken to estimate the level of apoptosis of blood leukocytes in patients with depression and to examine the mechanisms leading to apoptosis. Blood was taken from 29 patients with depression (age 48.2+/-...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.11.012

    authors： Szuster-Ciesielska A,Słotwińska M,Stachura A,Marmurowska-Michałowska H,Dubas-Slemp H,Bojarska-Junak A,Kandefer-Szerszeń M

    更新日期：2008-04-01 00:00:00

  • Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality.

    abstract：:Amisulpride clearly has the clinical profile of an atypical antipsychotic, characterised in particular by its lower propensity to induce extrapyramidal side effects as well as its greater efficacy in treating negative symptoms compared with classical neuroleptics. In addition to the clinical advantages over classical ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2003.09.006

    authors： Möller HJ

    更新日期：2003-10-01 00:00:00

  • Molecular aspects of monoamine oxidase B.

    abstract：:Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets. MAO B structure, function and kinetics are described as a background for the effect of alterations in its activity on behavior. The need...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2016.02.005

    authors： Ramsay RR

    更新日期：2016-08-01 00:00:00

  • The influence of ionotropic and metabotropic glutamate receptor ligands on anxiety-like effect of amphetamine withdrawal in rats.

    abstract：:Chronic amphetamine use results in anxiety-like states after drug cessation. The aim of the study was to determine a role of ionotropic and metabotropic glutamate receptor ligands in amphetamine-evoked withdrawal anxiety in the elevated plus-maze test in rats. In our study memantine (8 and 12 mg/kg), a noncompetitive ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2013.04.013

    authors： Koltunowska D,Gibula-Bruzda E,Kotlinska JH

    更新日期：2013-08-01 00:00:00

  • Postnatal development of parvalbumin immunoreactivity in axon terminals of basket and chandelier neurons in monkey neocortex.

    abstract：:1. Two classes of GABAergic inhibitory interneurons, chandelier and basket cells, are known regulators of pyramidal neurons. Parvalbumin (PV) a calcium binding protein, has been shown to be a marker for axon terminals of subpopulations of these interneurons. 2. Immunohistochemical methods were used in this study to ex...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(92)90084-r

    authors： Akil M,Lewis DA

    更新日期：1992-05-01 00:00:00

  • Correlation of fluphenazine plasma levels versus clinical response in patients: a pilot study.

    abstract：:Five schizophrenic patients (diagnosed using Research Diagnostic Criteria) under treatment with intramuscular fluphenazine decanoate or oral fluphenazine dihydrochloride had serial plasma fluphenazine and plasma prolactin levels determined by a direct radioimmunoassay method. Clinical state was assessed utilizing the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90068-4

    authors： Dudley J,Rauw G,Hawes EM,Keegan DL,Midha KK

    更新日期：1983-01-01 00:00:00

  • Long-term treatment of adjunctive quetiapine for bipolar mania.

    abstract：:This study evaluated the overall effectiveness and tolerability of adjunctive quetiapine as a continuation therapy for the long-term treatment of bipolar mania. Twenty-three patients were enrolled in this study and received quetiapine add-on treatment in combination with their existing or new mood stabilizers. The cli...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2005.04.024

    authors： Pae CU,Kim TS,Kim JJ,Lee SJ,Lee CU,Lee C,Paik IH

    更新日期：2005-06-01 00:00:00

  • Strain-dependent modification of behavior following antidepressant treatment.

    abstract：:The effects of repeated antidepressant drug treatment on behavioral outcome in Wistar Kyoto (WKY) rats, a putative animal model of depressive behavior, were compared to Wistar and Sprague-Dawley (SD) rats. Rats were treated with desipramine (norepinephrine [NE] uptake blocker), nomifensine (NE and dopamine [DA] uptake...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(02)00308-1

    authors： Tejani-Butt S,Kluczynski J,Paré WP

    更新日期：2003-02-01 00:00:00

  • Long-term impact of chronic variable stress in adolescence versus adulthood.

    abstract：:Adolescence is a period of active development of stress regulatory neurocircuitry. As a consequence, mechanisms that control the responses to stress are not fully matured during this developmental period, which may result in vulnerability to chronic stress. We hypothesized that adolescent chronic stress would have neg...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.08.003

    authors： Cotella EM,Gómez AS,Lemen P,Chen C,Fernández G,Hansen C,Herman JP,Paglini MG

    更新日期：2019-01-10 00:00:00

  • Activation syndrome induced by the antidepressant tianeptine and suicidal ideation: Evidence from a large depressed outpatient sample.

    abstract：OBJECTIVE:To determine the characteristics of the activation syndrome (AS) that predict the emergence or worsening of suicidal ideation (SI) in the first month of antidepressant treatment with tianeptine, as well as the temporal relationship between both conditions. METHOD:A naturalistic sample of 2422 depressed outpa...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109762

    authors： Lopez-Castroman J,Jaussent I,Gorwood P,Courtet P

    更新日期：2020-03-08 00:00:00

  • Impact of juvenile chronic stress on adult cortico-accumbal function: Implications for cognition and addiction.

    abstract：:Repeated exposure to stress during childhood is associated with increased risk for neuropsychiatric illness, substance use disorders and other behavioral problems in adulthood. However, it is not clear how chronic childhood stress can lead to emergence of such a wide range of symptoms and disorders in later life. One ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2017.06.015

    authors： Watt MJ,Weber MA,Davies SR,Forster GL

    更新日期：2017-10-03 00:00:00

  • Differential expression of mitogen-activated protein kinases and immediate early genes fos and jun in thalamus in schizophrenia.

    abstract：:Despite a growing body of evidence demonstrating that mitogen-activated protein (MAP) kinase pathways play an important physiological role in the CNS, little is known about their role and function in various mental disorders including schizophrenia. Our previous studies have shown increased expression of several inter...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.05.017

    authors： Kyosseva SV

    更新日期：2004-09-01 00:00:00

  • Neural substrates of opiate reinforcement.

    abstract：:A major component of opiate reward is derived from a drug action in the ventral tegmental area: (a) rats quickly learn to self-administer morphine directly into the ventral tegmentum, (b) intracranial self-administration into other brain sites is not quickly learned, and (c) narcotic antagonist microinjections into th...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90027-1

    authors： Bozarth MA,Wise RA

    更新日期：1983-01-01 00:00:00

  • Pramipexole for stage 2 treatment-resistant major depression: an open study.

    abstract：OBJECTIVE:To examine the effectiveness and safety of adjunctive pramipexole in the treatment of stage 2 treatment-resistant major depressive disorder. METHODS:This study included patients with moderate or non-psychotic severe major depressive disorder according to DSM-IV-TR criteria despite at least two adequate treat...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2010.07.035

    authors： Inoue T,Kitaichi Y,Masui T,Nakagawa S,Boku S,Tanaka T,Suzuki K,Nakato Y,Usui R,Koyama T

    更新日期：2010-12-01 00:00:00

  • The effect of ritanserin on treatment-resistant neuroleptic induced akathisia: case reports.

    abstract：:1. The authors report three cases of neuroleptic induced akathisia resistant to treatment with anticholinergics, benzodiazepines and betablockers. 2. All three patients were treated with Ritanserin 10 mg bid and improved rapidly and substantially. 3. Discontinuation of Ritanserin led to a recurrence of akathisia. ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(92)90076-q

    authors： Miller CH,Hummer M,Pycha R,Fleischhacker WW

    更新日期：1992-03-01 00:00:00