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Long-term treatment of adjunctive quetiapine for bipolar mania.

Abstract：

:This study evaluated the overall effectiveness and tolerability of adjunctive quetiapine as a continuation therapy for the long-term treatment of bipolar mania. Twenty-three patients were enrolled in this study and received quetiapine add-on treatment in combination with their existing or new mood stabilizers. The clinical assessment was carried out using the Young Mania Rating Scale (YMRS), Clinical Global Impression-severity(CGI-s), Hamilton Depression Rating Scale scores-17 item, Simpson-Angus Rating Scale and Barnes Akathisia Rating Scale at the baseline, 1, 4, 12 and 24 weeks. The YMRS and CGI-s decreased significantly from the baseline to the endpoint by 89.7% and 78.3%, respectively (p < 0.0001; p < 0.0001). By the end of the study, 22 patients showed at least 50% improvement in the YMRS score. This study suggests that quetiapine can be used as an adjunct in the long-term treatment of bipolar mania.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Pae CU,Kim TS,Kim JJ,Lee SJ,Lee CU,Lee C,Paik IH

doi

10.1016/j.pnpbp.2005.04.024

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

763-6

issue

5

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(05)00162-4

journal_volume

29

pub_type

临床试验,杂志文章

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