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Abnormal cerebral perfusion in chronic methamphetamine abusers: a study using 99MTc-HMPAO and SPECT.

Abstract：

:1. Cerebral blood flow of nine methamphetamine abusers with technetium-99m-hexamethylpropyleneamine oxime (HMPAO) and single photon emission computed tomography (SPECT) as well as morphological examination with magnetic resonance imaging (MRI) were investigated. 2. Six of these subjects exhibited multiple focal perfusion deficits in cerebral cortices without abnormalities in MRI including cerebral atrophy and/or infarctions. 3. Cerebral perfusion deficits were detected in methamphetamine abusers even after a long abstinence period, suggesting that vascular changes were irreversible to some degree. 4. HMPAO SPECT study appeared to be sensitive to the detection of cerebral perfusion abnormalities in drug abusers.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Iyo M,Namba H,Yanagisawa M,Hirai S,Yui N,Fukui S

doi

10.1016/s0278-5846(97)00079-1

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

789-96

issue

5

eissn

0278-5846

issn

1878-4216

pii

S0278584697000791

journal_volume

21

pub_type

临床试验,杂志文章

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