Abstract:
:There is a vast literature examining the neurochemical effects of anxiolytics throughout the rat brain; however, although the behavioural actions of anxiolytic drugs are routinely assessed in animal models of anxiety, the majority of neurochemical studies have been performed in rats with relatively 'normal' behavioural phenotypes. Since there is significant evidence that an anxious phenotype is associated with numerous neurochemical alterations, it is feasible that the central effects of anxiolytics may vary depending on the underlying behavioural state (and corresponding neuropathology) of the experimental animal. For this reason, the aim of the present study was to examine the effect of chronic anxiolytic drug administration on the central CCK and dopamine systems in anxious (isolated from weaning) and nonanxious (group-housed) Fawn-Hooded (FH) rats. It is important to note that these studies were performed in rats with continued access to ethanol, which may affect the responses to anxiolytic treatment. Chronic anxiolytic treatment with the selective CCK-B (CCK(2)) receptor antagonist, Ci-988 (0.3 mg/kg/day ip) or diazepam (2 mg/kg/day ip), induced numerous effects throughout the central nervous system (CNS), with Ci-988 inducing significant changes in the density of dopamine D(2) receptors, and diazepam producing marked changes in both dopamine D(2) and CCK-B receptor binding density as well as preproCCK mRNA expression. Interestingly, the neurochemical effects of these anxiolytic drugs varied significantly depending on the rearing conditions of the rats, demonstrating the importance of using adequate animal models when correlating the behavioural and central effects of drugs acting throughout the CNS.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Lodge DJ,Lawrence AJdoi
10.1016/S0278-5846(03)00032-0subject
Has Abstractpub_date
2003-05-01 00:00:00pages
451-8issue
3eissn
0278-5846issn
1878-4216pii
S0278-5846(03)00032-0journal_volume
27pub_type
杂志文章abstract::1. During a prospective and outpatient study the correlation between the lithium ratio and the incidence of lithium side effects and type of comedications was studied in 51 Iranian bipolar patients by using new direct method of measuring erythrocyte lithium concentration. 2. Results revealed that patients who received...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0278-5846(98)00058-x
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Evidence on antipsychotic prescribing decisions is limited. This pilot study quantified factors considered in choosing an antipsychotic and evaluated the influence of metabolic status on treatment decisions. METHODS:Prescribing decisions by 4 psychiatrists were examined based on 80 adult patients initiated ...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2010.11.018
更新日期:2011-01-15 00:00:00
abstract::Although ECT is a highly effective treatment for severe depression and other psychiatric syndromes, its mode of action is not known. Recent studies have suggested that effects of ECT on central neurotransmitter receptors may underlie its therapeutic action. The effects of chronically administered electroconvulsive sho...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/0278-5846(83)90120-3
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:Previous studies have indicated that the immune may be involved in the pathogenesis of tardive dyskinesia (TD). Some genetic polymorphisms in the human leukocyte antigen (HLA) I and II regions have been associated with TD, and the tumor necrosis factor-α (TNF-α) gene is located in the HLA III region. TNF-α le...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2011.12.007
更新日期:2012-04-27 00:00:00
abstract::Kainic acid (KA)-induced brain neuronal cell death (especially in the hippocampus) was shown to be mainly mediated by the intrinsic (mitochondrial) apoptotic pathway. This study investigated the regulation of the extrinsic apoptotic pathway mediated by Fas ligand/Fas receptor and components of the indispensable death-...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2015.04.009
更新日期:2015-12-03 00:00:00
abstract::The term "drug of abuse" is highly contextual. What constitutes a drug of abuse for one population of patients does not for another. It is therefore important to examine the needs of the patient population to properly assess the status of drugs of abuse. The focus of this article is on the bidirectional relationship b...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.pnpbp.2015.03.013
更新日期:2016-01-04 00:00:00
abstract::The early development of dopaminergic pathways has been attributed importance for the aetiology of schizophrenia. Several transcription factors are involved in the survival and maturation of dopamine neurons, including LMX1A, LMX1B and PITX3. The possibility that polymorphisms in these genes may influence the developm...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2010.05.032
更新日期:2010-08-16 00:00:00
abstract::The present study compared retrospectively in a clinical non-experimental setting the efficacy of buprenorphine (BUP) in different subgroups of dually diagnosed and non-dually diagnosed opioid-dependent patients: all the subjects included in the study showed severe long-lasting heroin addiction and 68.4% were affected...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/j.pnpbp.2005.10.007
更新日期:2006-03-01 00:00:00
abstract::The aim of the work was to study the effects of litter and the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) on the behaviour of mice after acute and chronic ethanol administration and withdrawal. Male outbred NIH/S mice, from 21 litters, were distributed among experimental groups and subjected t...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2004.06.008
更新日期:2004-11-01 00:00:00
abstract::1. The available evidence suggests that stress induced release of acetylcholine (ACh) in the brain has a significant role in mediating neuroendocrine, emotional, and physiological responses to stress. Recent findings also suggest that stress indirectly (via acetylcholine) and nicotine directly stimulates the HPA axis ...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0278-5846(00)00178-0
更新日期:2001-04-01 00:00:00
abstract::Accumulating evidence supports the hypothesis that modulation of glutamatergic system via NMDA receptors and mGlu5 receptors might be an effective antidepressant therapy. However, clinical application of NMDA and mGlu5 antagonists in the therapy of depression is still an open question. In the present study we investig...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2012.05.015
更新日期:2012-10-01 00:00:00
abstract::Several lines of evidence suggest that genetic factors might contribute to susceptibility to panic disorder. Our previous studies show that the brain-derived neurotrophic factor (BDNF) may play a role in the pathophysiology of major depressive disorders and eating disorders. Assuming that BDNF may be implicated in the...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2005.04.018
更新日期:2005-06-01 00:00:00
abstract::Depression is a serious and potentially life-threatening mental disorder with unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) and microRNAs (miRNAs) play critical roles in the etiology of depression. However, the molecular mechanisms are not fully understood. Expression of miR-1...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2015.09.004
更新日期:2016-02-04 00:00:00
abstract::Metabotropic glutamate receptors (mGlu) have been implicated in the regulation of physiological and behavioral processes. Pharmacological evidence involves group I mGlu receptors in the regulation of emotional states and antagonism of these receptors has been proposed as a novel class of anxiolytic drugs having also a...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2012.09.011
更新日期:2013-01-10 00:00:00
abstract::Depression is common among lung cancer patients. Increasing evidence has suggested that hypothalamic-pituitary-adrenal (HPA) axis and pro-inflammatory cytokines may play a key role in the pathophysiology of depression as well as cancer. This pilot study investigated the efficacy of sputum interleukin (IL)-6, tumor nec...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2013.08.004
更新日期:2013-12-02 00:00:00
abstract::1. U-50,488 is a structurally novel, non-mu opioid. In the present experiments it was compared to the reputed kappa opioid agonists, ketazocine, ethylketocyclazocine and bremazocine as regards analgesic cross tolerance to morphine and U-50,488, antagonism of analgesia by naloxone and MR-2266 (in vivo pA2 determination...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0278-5846(82)80130-9
更新日期:1982-01-01 00:00:00
abstract::1. The great interest for new drugs having cognition enhancing properties is highlighted, particularly for the treatment of dementia of Alzheimer type. 2. A short survey is given of the pharmacological models currently used to mimic cognitive impairment. 3. A systematic survey is given of the major cognition enhancing...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/0278-5846(89)90111-5
更新日期:1989-01-01 00:00:00
abstract::1. The authors attempted to detect a possible effect of treatment with phenelzine on a physiological response to nicotine in the rat. 2. Positive findings in an animal model suggest the feasibility of more complicated experiments in animals and the possibility of studies involving human subjects. 3. Treatment of Sprag...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/0278-5846(93)90065-z
更新日期:1993-09-01 00:00:00
abstract::There is evidence for the involvement of the endocrine system in schizophrenia. This involment was widely investigated in female patients. In the current study, we examined prolactin and estradiol serum levels in hospitalized unmedicated men with first-episode and recurrent schizophrenia and then tested possible corre...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2006.09.016
更新日期:2007-03-30 00:00:00
abstract::Latent inhibition (LI) is a behavioural paradigm in which repeated exposure to a stimulus without consequence inhibits the formation of any new associations with that stimulus. To the extent that LI reflects a process of leaming to ignore irrelevant stimuli, disrupted LI has been suggested as an animal model for the a...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0278-5846(01)00296-2
更新日期:2002-04-01 00:00:00
abstract::We have examined the effects of postnatal handling of rat pups from Days 1 to 21 on the development of the intracellular, glucocorticoid receptor in the hippocampus, and pituitary transcortin, and corticoid binding globulin in plasma. All animals were sacrificed 10-14h following adrenalectomy and the in vitro receptor...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/0278-5846(85)90050-8
更新日期:1985-01-01 00:00:00
abstract::Nicotine consumption through smoking affects anxious states in humans. However, the precise role of nicotinic acetylcholine receptor (nAChR) circuitry in the regulation of anxiety remains elusive. The Lynx protein Lypd6 is highly enriched in synaptic loci and has been previously identified as an endogenous inhibitor o...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2017.11.025
更新日期:2018-03-02 00:00:00
abstract::Human societies demand of its composing members the development of a wide array of social tools and strategies. A notable example is human outstanding ability to cooperate with others, in all its complex forms, depicting the reality of a highly demanding social framework in which humans need to be integrated as to att...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.pnpbp.2017.11.014
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:γ-aminobutyrate (GABA) and Glutamate (Glu) are respectively two major inhibitory and excitatory neurotransmitters in the central nervous system and recent theories propose that both of their signaling complexes are compromised in patients with schizophrenia. METHODS:The changes in plasma GABA, Glu and GABA/...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/j.pnpbp.2010.07.006
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:Some studies find a relationship between certain personality traits, as impulsivity or sensation seeking, and caffeine consumption, but these studies do not consider the potential confounding effect of smoking on caffeine intake, a co-occurrence that has been well demonstrated in epidemiological and clinical...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2007.02.006
更新日期:2007-06-30 00:00:00
abstract::Consistent evidence has shown that learning may be produced in paradigms using electrical stimulation of the inferior colliculus as unconditioned stimulus (US). Much evidence has also been provided for the involvement of dopamine in the setting up of adaptive responses to aversive states generated at this mesencephali...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/S0278-5846(03)00153-2
更新日期:2003-09-01 00:00:00
abstract::Tryptophan hydroxylase-2 (TPH2) is the rate-limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and has been implicated in the pathogenesis of major depressive disorder (MDD) and in the mechanism of antidepressant action. This study aimed to investigate whether common genetic va...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.pnpbp.2009.02.020
更新日期:2009-06-15 00:00:00
abstract::1. In vertebrates as in invertebrates, protein kinase C appears to have a key role in learning and memory, probably given its involvement in synaptic plasticity. 2. Hippocampal PKC in mammalians is activated by learning in a large variety of memory tasks. However, the kind of information processed, the type of task, a...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0278-5846(97)00015-8
更新日期:1997-04-01 00:00:00
abstract::Despite therapeutic treatment with lithium or valproate, patients with bipolar I disorder often require adjunctive therapy to treat persistent symptoms. In order to evaluate the effects of quetiapine for bipolar symptoms inadequately responsive to mood stabilizers, a retrospective chart review was undertaken at the Ve...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章
doi:10.1016/S0278-5846(03)00145-3
更新日期:2003-08-01 00:00:00
abstract::Over the last decade there has been an explosion of new drugs of abuse, so called legal highs or novel psychoactive substances (NPS). Many of these abused drugs have unknown pharmacology, but their biological effects can be anticipated from their molecular structure and possibly also from online user reports. When con...
journal_title:Progress in neuro-psychopharmacology & biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.pnpbp.2015.07.010
更新日期:2016-01-04 00:00:00