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Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia.

Abstract：

:The early development of dopaminergic pathways has been attributed importance for the aetiology of schizophrenia. Several transcription factors are involved in the survival and maturation of dopamine neurons, including LMX1A, LMX1B and PITX3. The possibility that polymorphisms in these genes may influence the development and/or the maintenance of dopaminergic neurons prompted us to investigate if five single nucleotide polymorphisms (SNPs) previously linked to Parkinson's disease are associated with this disorder. Preliminary evidence that genetic variation in LMX1A (rs6668493, rs4657411), LMX1B (rs10987386) and PITX3 (rs4919621) may increase the risk of developing schizophrenia is presented.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Bergman O,Westberg L,Nilsson LG,Adolfsson R,Eriksson E

doi

10.1016/j.pnpbp.2010.05.032

subject

Has Abstract

pub_date

2010-08-16 00:00:00

pages

1094-7

issue

6

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(10)00216-2

journal_volume

34

pub_type

杂志文章

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