Abstract：
:Neurodevelopmental factors have been implicated in the pathophysiology of mental disorders. However, the evidence regarding their role in bipolar disorder is controversial. We reviewed the pertinent literature searching for evidence regarding a neurodevelopmental origin of bipolar disorder. Findings from clinical, epidemiological, neuroimaging, and post-mortem studies are discussed, as well as the implications of the available data for a better understanding of the mechanisms involved in the genesis of bipolar disorder. While some evidence exists for developmental risk factors in bipolar disorder, further research is needed to determine the precise extent of their contribution to pathogenesis. The timing and course of such developmentally mediated neurobiological alterations also need to be determined. Of particular importance for further study is the possibility that bipolar disorder may be mediated by an abnormal maturation of brain structures involved in affect regulation.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Sanches M,Keshavan MS,Brambilla P,Soares JCdoi
10.1016/j.pnpbp.2008.04.017subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1617-27issue
7eissn
0278-5846issn
1878-4216pii
S0278-5846(08)00133-4journal_volume
32pub_type
杂志文章,评审abstract：:During nonpathological aging, quantitative changes occur in the pre- and post-synaptic elements of both the dopamine and serotonin systems. The level of dopamine in the human striatum declines up to 50% with age, while smaller and more variable changes are found in rodent brain (0-30%). Postsynaptically, the density o...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(87)90053-4
更新日期：1987-01-01 00:00:00
abstract：:Due to global industrialization, the light cycle is shifting to longer daytime. Mounting evidence indicates that social developmental disorders may correlate with longer periods of daytime in childhood. However, the exact mechanisms of this link remain unclear. To examine the impact of longer day-time on psychosocial ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2011.01.008
更新日期：2011-08-01 00:00:00
abstract：:In the brains of patients with Alzheimer's disease (AD) signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes to the pathogenesis of the disease. A d...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0278-5846(01)00192-0
更新日期：2001-10-01 00:00:00
abstract：:1. It has been postulated that the interrelated processes of neurodegeneration, neuroplasticity, and neuroimmunological abnormalities may play a role in the pathophysiology of schizophrenia. Since, interleukins are produced in the central nervous system and have cytokine and growth promoting properties, they are an ob...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(93)90072-z
更新日期：1993-05-01 00:00:00
abstract：:1. Adrafmil is a novel vigilance promoting agent developed in France by Louis Lafon Laboratories. 2. Adrafinil causes increased locomotion without producing stereotypical activity in canines tested in an open field. 3. The effectiveness of a single treatment is long-lasting, and the effectiveness persists over repeate...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0278-5846(00)00103-2
更新日期：2000-07-01 00:00:00
abstract：:Nutrition is one of the critical factors insuring adequate growth and development in all species. In particular, brain development is sensitive to specific nutrient intake such as proteins and lipids, which are important for cell membrane formation and myelinization. Carbohydrate intake insures adequate short-term ene...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2005.08.010
更新日期：2005-12-01 00:00:00
abstract：:1. Genetic databases are an expanding and readily accessible repository of information on the mapping and sequencing of the human genome, and that of other model organisms. The integration and application of this information to neuropsychiatric disease is illustrated using neuroendocrine and neuropharmacologic data, c...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(91)90078-f
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Weight gain is a major side effect of antipsychotic treatment. Some atypical antipsychotic agents have profound effects on weight. Body weight is regulated by a complex system, including both peripheral and central factors. Two of the hormones that seem to play an important role in the regulation of food int...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2008.03.015
更新日期：2008-08-01 00:00:00
abstract：:While white matter impairments play an integral part in the pathophysiology of schizophrenia and bipolar disorder, the literature on white matter abnormality differences between the two disorders is insufficient. The University of California Los Angeles Consortium for Neuropsychiatric Phenomic LA5c public dataset, inc...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2020.110175
更新日期：2020-11-12 00:00:00
abstract：:This study evaluated the overall effectiveness and tolerability of adjunctive quetiapine as a continuation therapy for the long-term treatment of bipolar mania. Twenty-three patients were enrolled in this study and received quetiapine add-on treatment in combination with their existing or new mood stabilizers. The cli...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.pnpbp.2005.04.024
更新日期：2005-06-01 00:00:00
abstract：:1. During a prospective and outpatient study the correlation between the lithium ratio and the incidence of lithium side effects and type of comedications was studied in 51 Iranian bipolar patients by using new direct method of measuring erythrocyte lithium concentration. 2. Results revealed that patients who received...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0278-5846(98)00058-x
更新日期：1998-08-01 00:00:00
abstract：:Lithium remains the treatment of choice for many patients suffering from bipolar disorder. However, long-term treatment with lithium carries the potential to cause renal and thyroid dysfunction. Lithium-induced nephropathies are characterised by deterioration of urinary concentrating ability as well as, less frequentl...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.pnpbp.2007.11.015
更新日期：2008-04-01 00:00:00
abstract：:Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2015.04.002
更新日期：2016-01-04 00:00:00
abstract：:Despite considerable efforts and successes investigating the function of the hippocampal formation in memory processes, there are still numerous elusive key issues. Some of them will be addressed in this review. We will argue that recent evidence supports hippocampal participation in several memory processes, such as ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0278-5846(01)00153-1
更新日期：2001-05-01 00:00:00
abstract：:Although several recent studies have suggested that neuroinflammation plays a role in depression, both medication and neuroinflammatory preventive strategies have been poorly investigated. Recent studies have indicated that preconditioning with lipopolysaccharide (LPS) reduces the damage that occurs following ischemic...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2020.109978
更新日期：2020-12-20 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration with unclear etiology and no effective treatment to date. ALS is, however, increasingly recognized as a multisystem disorder associated with impaired cognition. The overlap between ALS and dementia at clinical, genetic and neuropathol...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2010.07.017
更新日期：2011-03-30 00:00:00
abstract：:The main goal of the present study was to evaluate binding to serotonin in the neocortex surrounding the epileptic focus of patients with mesial temporal lobe epilepsy (MTLE). Binding to 5-HT, 5-HT(1A), 5-HT(4), 5-HT(7) receptors and serotonin transporter (5-HTT) in T1-T2 gyri of 15 patients with MTLE and their correl...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2007.04.014
更新日期：2007-08-15 00:00:00
abstract：:Supratherapeutic doses of the analgesic acetaminophen (paracetomol) are reported to promote social behavior in Swiss mice. However, we hypothesized that it might not promote sociability in other strains due to cannabinoid CB(1) receptor-mediated inhibition of serotonin (5-HT) transmission in the frontal cortex. We exa...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2012.04.011
更新日期：2012-08-07 00:00:00
abstract：:Repeated exposure to stress during childhood is associated with increased risk for neuropsychiatric illness, substance use disorders and other behavioral problems in adulthood. However, it is not clear how chronic childhood stress can lead to emergence of such a wide range of symptoms and disorders in later life. One ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2017.06.015
更新日期：2017-10-03 00:00:00
abstract：:1. After pretraining in an undrugged state, young (6 months) and aged (18-24 months) rats were trained on a spatial learning-set task after receiving one of four doses of diazepam (1, 2, 3 or 5 mg/kg) or the drug vehicle. The effects of 5 mg/kg of diazepam were also assessed on the spatial learning-set task one full h...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(96)00065-6
更新日期：1996-07-01 00:00:00
abstract：:1. Two classes of GABAergic inhibitory interneurons, chandelier and basket cells, are known regulators of pyramidal neurons. Parvalbumin (PV) a calcium binding protein, has been shown to be a marker for axon terminals of subpopulations of these interneurons. 2. Immunohistochemical methods were used in this study to ex...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(92)90084-r
更新日期：1992-05-01 00:00:00
abstract：:We aimed to examine the effects of infertility treatments on the risk of Autism Spectrum Disorder (ASD). Data were from a representative national registry on 110,093 male live births in Israel (born: 1999-2008; and ASD: 975, 0.9%). Infertility treatments included In Vitro Fertilization (IVF), and five hormone treatmen...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2018.05.022
更新日期：2018-08-30 00:00:00
abstract：:Cocaine dependence is a complex psychiatric disorder that is highly comorbid with other psychiatric traits. Twin and adoption studies suggest that genetic variants contribute substantially to cocaine dependence susceptibility, which has an estimated heritability of 65-79%. Here we performed a meta-analysis of genome-w...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,meta分析
doi：10.1016/j.pnpbp.2019.109667
更新日期：2019-08-30 00:00:00
abstract：:Suriclone, a new psychotherapeutic agent chemically unrelated to benzodiazepines or phenothiazines was assessed in a single-blind dose-ranging study to determine its efficacy and safety in out-patients with generalized anxiety disorder. Suriclone was an effective anxiolytic drug at a dose range between 1.2 mg. and 3.6...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/0278-5846(83)90071-4
更新日期：1983-01-01 00:00:00
abstract：:Although the memory deficits produced by pre-training benzodiazepines administration have been extensively demonstrated both in humans and in animal studies, there is considerable controversy about the involvement of the state-dependency phenomenon on benzodiazepines-induced anterograde amnesia. The present study aime...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2012.01.013
更新日期：2012-04-27 00:00:00
abstract：:Group II metabotropic glutamate receptor (mGluR2/3) agonists once showed promise as non-dopaminergic antipsychotic drugs because of their efficacy in alleviating symptoms of schizophrenia (SZ) in both animal models and human patients. However, the recent failure of Phase III clinical trials dealt a huge blow to the sc...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2015.02.012
更新日期：2015-07-03 00:00:00
abstract：:Altered cerebral energy metabolism and mitochondrial dysfunction in periphery and in brain are implicated in the pathophysiology of schizophrenia. This study investigated whether cerebral glucose metabolism (rCGM) abnormalities are linked to altered mitochondrial complex I activity in the periphery, in schizophrenia. ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2006.12.025
更新日期：2007-05-09 00:00:00
abstract：:Study of alcoholic chronic organic brain syndrome may have applicability to the large population of alcoholics with less severe cerebral dysfunction. Brain impairment in alcoholics may be conceptualized as two clinically and neuropathologically distinguishable organic brain syndromes: alcohol amnestic disorder or Kors...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0278-5846(86)90069-2
更新日期：1986-01-01 00:00:00
abstract：:There have been few attempts to integrate neurobiological and cognitive models of obsessive-compulsive disorder (OCD), although this might constitute a key approach to clarify the complex etiology of the disorder. Our study aimed to explore the neural correlates underlying dysfunctional beliefs hypothesized by cogniti...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2013.07.016
更新日期：2013-12-02 00:00:00
abstract：:In people with schizophrenia, cognitive abilities - including memory - are strongly associated with functional outcome. Long-term potentiation (LTP) is a form of neuroplasticity that is believed to be the physiological basis for memory. It has been postulated that antipsychotic medication can impair long-term potentia...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2014.05.001
更新日期：2014-10-03 00:00:00
