Abstract:
:In people with schizophrenia, cognitive abilities - including memory - are strongly associated with functional outcome. Long-term potentiation (LTP) is a form of neuroplasticity that is believed to be the physiological basis for memory. It has been postulated that antipsychotic medication can impair long-term potentiation and cognition by altering dopaminergic transmission. Thus, a systematic review was performed in order to assess the relationship between antipsychotics and D2 antagonists on long-term potentiation. The majority of studies on LTP and antipsychotics have found that acute administration of antipsychotics was associated with impairments in LTP in wild-type animals. In contrast, chronic administration and acute antipsychotics in animal models of schizophrenia were not. Typical and atypical antipsychotics and other D2 antagonists behaved similarly, with the exception of clozapine and olanzapine. Clozapine caused potentiation independent of tetanization, while olanzapine facilitated tetanus-induced potentiation. These studies are limited in their ability to model the effects of antipsychotics in patients with schizophrenia as they were largely performed in wild-type animals as opposed to humans with schizophrenia, and assessed after acute rather than chronic treatment. Further studies using patients with schizophrenia receiving chronic antipsychotic treatment are needed to better understand the effects of these medications in this population.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Price R,Salavati B,Graff-Guerrero A,Blumberger DM,Mulsant BH,Daskalakis ZJ,Rajji TKdoi
10.1016/j.pnpbp.2014.05.001subject
Has Abstractpub_date
2014-10-03 00:00:00pages
83-91eissn
0278-5846issn
1878-4216pii
S0278-5846(14)00092-Xjournal_volume
54pub_type
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