当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Moclobemide, an inhibitor of MAO-A, does not increase daytime plasma melatonin levels in normal humans.

Moclobemide, an inhibitor of MAO-A, does not increase daytime plasma melatonin levels in normal humans.

Abstract：

:1. Plasma melatonin concentrations were determined after administration of single oral doses (100, 200 and 300 mg) of moclobemide, a reversible inhibitor of monoamine oxidase (MAO) with predominant effects on the A-type of the enzyme, to eight young, healthy male volunteers in a double-blind, random-order, placebo-controlled study. The investigation was later continued in an open fashion by giving a single 10 mg dose of the MAO-B inhibitor deprenyl to the same subjects. 2. Neither drug had any effects on plasma melatonin levels, in spite of very marked MAO-A inhibition after moclobemide (as evidenced by up to 79% average decreases in the plasma concentrations of 3,4-dihydroxyphenylglycol, a deaminated metabolite of noradrenaline) and over 90% inhibition of MAO-B activity in blood platelets after deprenyl. 3. It is concluded that daytime human plasma melatonin levels do not accurately reflect MAO-A inhibition in acute drug studies.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Scheinin M,Koulu M,Vakkuri O,Vuorinen J,Zimmer RH

doi

10.1016/0278-5846(90)90065-o

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

73-82

issue

1

eissn

0278-5846

issn

1878-4216

pii

0278-5846(90)90065-O

journal_volume

14

pub_type

临床试验,杂志文章,随机对照试验

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