当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Depression in premenopausal women: gonadal hormones and serotonergic system assessed by D-fenfluramine challenge test.

Depression in premenopausal women: gonadal hormones and serotonergic system assessed by D-fenfluramine challenge test.

Abstract：

PURPOSE:The aim of the study was to compare the activity of gonadal hormones and serotonergic system in premenopausal women with or without depression in relation to clinical and hormonal indices of menopause. METHODS:The sample included 60 women with single or recurrent major depressive episode with disease onset after 38 year of age (mean age 43 years) and 30 healthy control women (mean age 41 years). Psychometric assessment was done by means of 17-item Hamilton Depression Rating Scale (HDRS) and the Beck Depression Inventory (BDI). The presence of menopausal symptoms was assessed by Kupperman Menopause Index (KMI). Activity of gonadal axis was measured by estimating estradiol and follicle-stimulating hormone (FSH) levels. For the assessment of central serotonergic activity, the D-fenfluramine test was used. RESULTS:Depressed women had higher intensity of menopausal symptoms, significantly lower concentration of estradiol, and higher of FSH than control women. Severity of depression correlated with both the intensity of menopausal symptoms and the concentration of FSH. Baseline levels of prolactin were not different in both groups. Following D-fenfluramine administration, there was a significant increase in prolactin concentration in healthy women and a transient decrease in depressed ones. Baseline cortisol level was significantly higher in depressed women and correlated with the severity of depression. D-Fenfluramine challenge caused a significant increase of cortisol secretion in healthy women and a significant decrease in depressed ones. A relationship was observed between baseline estradiol, FSH, and cortisol level and the magnitude of prolactin and cortisol response to D-fenfluramine. CONCLUSIONS:In premenopausal women, a high degree of interconnections was demonstrated between symptoms of depression and symptoms of menopause on both clinical and hormonal level. The results confirm the association between depressive and menopausal symptoms as well as an involvement of gonadal hormones, cortisol, and serotonin deficiency in this process.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Rajewska J,Rybakowski JK

doi

10.1016/S0278-5846(03)00085-X

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

705-9

issue

4

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(03)00085-X

journal_volume

27

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Alcoholic organic brain disease: nosology and pathophysiologic mechanisms.

    abstract：:Study of alcoholic chronic organic brain syndrome may have applicability to the large population of alcoholics with less severe cerebral dysfunction. Brain impairment in alcoholics may be conceptualized as two clinically and neuropathologically distinguishable organic brain syndromes: alcohol amnestic disorder or Kors...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(86)90069-2

    authors： Martin PR,Adinoff B,Weingartner H,Mukherjee AB,Eckardt MJ

    更新日期：1986-01-01 00:00:00

  • Estradiol, TRH and striatal dopaminergic mechanisms.

    abstract：:1. Estrogens have been shown to decrease the effect of apomorphine in a variety of animal behavioral models reflecting the sensitivity of striatal and mesolimbic dopamine receptors. 2. These include circling, and locomotor activity, in rats and suppression of midbrain tremor as well as lingual dyskinesia in monkeys. 3...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(82)80149-8

    authors： Bédard PJ,Malouin F,Dipaolo T,Labrie F

    更新日期：1982-01-01 00:00:00

  • 5-HT1A receptor responsivity in anxiety disorders and depression.

    abstract：:1. Azapirones, selective partial agonists at the 5-HT1A receptor subtype, induce hypothermia and corticotropin (ACTH)/cortisol release as specific functional correlates of central 5-HT1A receptor activation. 2. Compared to controls, hypothermic and ACTH/cortisol responses to the azapirone ipsapirone are attenuated in ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(91)90001-h

    authors： Lesch KP

    更新日期：1991-01-01 00:00:00

  • Effects of chronic alcohol consumption in weanling rats on brain gangliosides.

    abstract：:Chronic ingestion of ethyl alcohol in pre-weanling rats can decrease whole-brain levels of sialic acid (SA), an acidic sugar that serves as terminal groups on glycolipids (gangliosides) and glycoproteins. Because SA occurs in both classes of membrane-bound chemicals, the alcohol effect could be on either or both paren...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(86)90053-9

    authors： Klemm WR,Foster DM

    更新日期：1986-01-01 00:00:00

  • Roles of olfactory system dysfunction in depression.

    abstract：:The olfactory system is involved in sensory functions, emotional regulation and memory formation. Olfactory bulbectomy in rat has been employed as an animal model of depression for antidepressant discovery studies for many years. Olfaction is impaired in animals suffering from chronic stress, and patients with clinica...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2014.05.013

    authors： Yuan TF,Slotnick BM

    更新日期：2014-10-03 00:00:00

  • Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.

    abstract：:Endogenous cannabinoid ligands and cannabinoid CB1 receptor agonists have been shown to exert anticonvulsant effects in various experimental models of epilepsy. The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA-a highly selective cannabinoid CB1 receptor agonist) on the pr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.07.001

    authors： Andres-Mach M,Zolkowska D,Barcicka-Klosowska B,Haratym-Maj A,Florek-Luszczki M,Luszczki JJ

    更新日期：2012-12-03 00:00:00

  • Molecular basis of amyotrophic lateral sclerosis.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration with unclear etiology and no effective treatment to date. ALS is, however, increasingly recognized as a multisystem disorder associated with impaired cognition. The overlap between ALS and dementia at clinical, genetic and neuropathol...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2010.07.017

    authors： Liscic RM,Breljak D

    更新日期：2011-03-30 00:00:00

  • Noradrenergic facilitation of shock-probe defensive burying in lateral septum of rats, and modulation by chronic treatment with desipramine.

    abstract：:We have previously shown that acute stress-induced release of norepinephrine (NE) facilitates anxiety-like behavioral responses to stress, such as reduction in open-arm exploration on the elevated-plus maze and in social behavior on the social interaction test. Since these responses represent inhibition of ongoing beh...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.11.015

    authors： Bondi CO,Barrera G,Lapiz MD,Bedard T,Mahan A,Morilak DA

    更新日期：2007-03-30 00:00:00

  • Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced responses to nicotine.

    abstract：:Nicotine consumption through smoking affects anxious states in humans. However, the precise role of nicotinic acetylcholine receptor (nAChR) circuitry in the regulation of anxiety remains elusive. The Lynx protein Lypd6 is highly enriched in synaptic loci and has been previously identified as an endogenous inhibitor o...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.11.025

    authors： Arvaniti M,Polli FS,Kohlmeier KA,Thomsen MS,Andreasen JT

    更新日期：2018-03-02 00:00:00

  • Examination of the interactions of the amyloid precursor protein carboxyl terminus to intracellular protein: possible role in apoptosis.

    abstract：:1. The carboxyl terminus of the amyloid precursor protein (APP) has several identified regions that may potentially contribute to the pathogenic effects of Alzheimer's disease (AD). To examine these effects, the authors iodinated a short synthetic peptide corresponding to amino acids 679-687 of APP695. They also produ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(99)00046-9

    authors： Daly J,Lahiri DK,Kotwal GJ

    更新日期：1999-07-01 00:00:00

  • Interferon: a candidate as the endogenous substance preventing tolerance and dependence to brain opioids.

    abstract：:It has been suggested that protein synthesis and immunological factors play a role in the development of tolerance and dependence to opiates. Interferon (IFN) is known to influence protein synthesis and the immune system. Our and other data suggest that IFN may be an agent that prevents the development of tolerance an...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Dafny N

    更新日期：1984-01-01 00:00:00

  • High-glucose/high-cholesterol diet in zebrafish evokes diabetic and affective pathogenesis: The role of peripheral and central inflammation, microglia and apoptosis.

    abstract：:Neuroinflammation and metabolic deficits contribute to the etiology of human affective disorders, such as anxiety and depression. The zebrafish (Danio rerio) has recently emerged as a powerful new model organism in CNS disease modeling. Here, we exposed zebrafish to 2% glucose and 10% cholesterol for 19 days to experi...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109752

    authors： Wang J,Li Y,Lai K,Zhong Q,Demin KA,Kalueff AV,Song C

    更新日期：2020-01-10 00:00:00

  • An MRI study of the basal ganglia in autism.

    abstract：:1. High-resolution MRI scans were obtained from 35 relatively high-functioning persons with autism and 36 healthy controls, comparable in age, gender, and IQ. 2. Volumetric measurements were obtained from manual tracing of the bilateral caudate, putamen, and globus pallidus. 3. An increased volume of the caudate nucle...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(99)00020-2

    authors： Sears LL,Vest C,Mohamed S,Bailey J,Ranson BJ,Piven J

    更新日期：1999-05-01 00:00:00

  • Effects of kawain and dihydromethysticin on field potential changes in the hippocampus.

    abstract：:1. The kava-pyrones kawain and dihydromethysticin are constituents of Piper methysticum which exert anticonvulsant, analgesic and anxiolytic properties. 2. In the present study the effect of these kava-pyrones were tested on field potential changes (fp) induced by omission of the extracellular Mg2+, recorded from the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(97)00042-0

    authors： Walden J,von Wegerer J,Winter U,Berger M,Grunze H

    更新日期：1997-05-01 00:00:00

  • Polyunsaturated fatty acids and suicide risk in mood disorders: A systematic review.

    abstract：:Deficiency of omega-3 polyunsaturated fatty acids (PUFAs) and an alteration between the ratio of omega-3 and omega-6 PUFAs may contribute to the pathogenesis of bipolar disorder and unipolar depression. Recent epidemiological studies have also demonstrated an association between the depletion of PUFAs and suicide. Our...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2016.11.007

    authors： Pompili M,Longo L,Dominici G,Serafini G,Lamis DA,Sarris J,Amore M,Girardi P

    更新日期：2017-03-06 00:00:00

  • Insulin resistance and metabolic profile in antipsychotic naïve schizophrenia patients.

    abstract：OBJECTIVES:Several studies have suggested insulin resistance related to dyslipidemia and body weight in drug treated schizophrenia patients. Although, insulin resistance or impaired glucose tolerance is also reported in antipsychotic naïve schizophrenia patients, their relationship with dyslipidemic changes and body we...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2010.06.011

    authors： Dasgupta A,Singh OP,Rout JK,Saha T,Mandal S

    更新日期：2010-10-01 00:00:00

  • Characterisation of spinophilin immunoreactivity in postmortem human brain homogenates.

    abstract：:Spinophilin is a multifunctional scaffold protein that regulates the formation and function of dendritic spines and plays a role in neuronal migration. The distinct roles of spinophilin depend on its localization and the direct interaction with other proteins, which may target spinophilin to specific locations within ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.09.019

    authors： Brocos-Mosquera I,Nuñez Del Moral A,Morentin B,Meana JJ,Callado LF,Erdozain AM

    更新日期：2018-02-02 00:00:00

  • The mouse light-dark paradigm: a review.

    abstract：:1. The light/dark paradigm is based on the innate aversion of rodents to brightly illuminated areas and on the spontaneous exploratory behaviour of the animals, applying mild stressors i.e. novel environment and light. The test apparatus consists of a small dark secure compartment (one third) and a large illuminated a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0278-5846(00)00151-2

    authors： Hascoët M,Bourin M,Nic Dhonnchadha BA

    更新日期：2001-01-01 00:00:00

  • Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder.

    abstract：:Linkage studies in bipolar disorder (BPD) suggest that a susceptibility locus exists on chromosome 18p11. The myo-inositol monophosphatase 2 gene (IMPA2) maps to this genomic region. Myo-inositol monophosphatase dephosphorylates inositol monophosphate, regenerating free inositol. Lithium, a common treatment for BPD, h...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.pnpbp.2010.08.015

    authors： Bloch PJ,Weller AE,Doyle GA,Ferraro TN,Berrettini WH,Hodge R,Lohoff FW

    更新日期：2010-12-01 00:00:00

  • The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression.

    abstract：:A growing body of evidence suggests that inflammation, mitochondrial dysfunction and oxidant-antioxidant imbalance may play a significant role in the development and progression of depression. Elevated levels of reactive oxygen and nitrogen species - a result of oxidant-antioxidant imbalance - may lead to increased da...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2017.06.036

    authors： Czarny P,Wigner P,Galecki P,Sliwinski T

    更新日期：2018-01-03 00:00:00

  • Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice.

    abstract：:Supratherapeutic doses of the analgesic acetaminophen (paracetomol) are reported to promote social behavior in Swiss mice. However, we hypothesized that it might not promote sociability in other strains due to cannabinoid CB(1) receptor-mediated inhibition of serotonin (5-HT) transmission in the frontal cortex. We exa...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.04.011

    authors： Gould GG,Seillier A,Weiss G,Giuffrida A,Burke TF,Hensler JG,Rock C,Tristan A,McMahon LR,Salazar A,O'Connor JC,Satsangi N,Satsangi RK,Gu TT,Treat K,Smolik C,Schultz ST

    更新日期：2012-08-07 00:00:00

  • Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers.

    abstract：:People with Huntington's disease (HD) exhibit altered processing of emotional information, especially disgust and other negative emotions. These impairments are likely due to the effects of the disease on underlying brain networks. We examined whether oxytocin, when given intranasally, would normalise aberrant brain r...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.09.023

    authors： Labuschagne I,Poudel G,Kordsachia C,Wu Q,Thomson H,Georgiou-Karistianis N,Stout JC

    更新日期：2018-02-02 00:00:00

  • Tryptophan availability, 5HT synthesis and 5HT function.

    abstract：:1. Tryptophan increases 5HT synthesis, but the extent to which it increases 5HT release and therefore 5HT function is unclear. 2. The possibility that increased 5HT levels will lead to increased 5HT release is enhanced when 5HT neurons are firing at a higher rate. The rate of firing of 5HT neurons is increased as the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(89)90126-7

    authors： Young SN,Teff KL

    更新日期：1989-01-01 00:00:00

  • Potentiation of muscimol-induced long-term depression by benzodiazepines but not zolpidem.

    abstract：:Zolpidem is a rapid-onset, short-duration, quickly eliminated imidazopyridine hypnotic. It has been suggested that zolpidem may produce less memory and cognitive impairment than benzodiazepines (BZs) due to its low binding affinity for BZ receptor subtypes found in areas of the brain that are involved in learning and ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(02)00254-3

    authors： Akhondzadeh S,Mohammadi MR,Kashani L

    更新日期：2002-10-01 00:00:00

  • Structure/function interrelationships in patients with schizophrenia who have persistent auditory verbal hallucinations: A multimodal MRI study using parallel ICA.

    abstract：:There is accumulating neuroimaging evidence for both structural and functional abnormalities in schizophrenia patients with persistent auditory verbal hallucinations (AVH). So far, the direct interrelationships between altered structural and functional changes underlying AVH are unknown. Recently, it has become possib...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.03.007

    authors： Kubera KM,Rashidi M,Schmitgen MM,Barth A,Hirjak D,Sambataro F,Calhoun VD,Wolf RC

    更新日期：2019-07-13 00:00:00

  • Novel therapeutic targets in mood disorders: Pentoxifylline (PTX) as a candidate treatment.

    abstract：:Numerous pharmacological treatments for mood disorders are currently available; however, rates of treatment resistance, relapse and recurrence remain high. Therefore, novel treatments acting outside of the conventionally targeted monoamine system are urgently needed to improve patient outcomes. Emerging and converging...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2020.110032

    authors： Siegel AN,Rodrigues N,Nasri F,Wilkialis L,Lipsitz O,Lee Y,Gill H,Subramaniapillai M,Phan L,Majeed A,Lui LMW,Rashidian H,Ho R,Toma S,Goldstein BI,Mansur RB,McIntyre RS,Rosenblat JD

    更新日期：2021-01-10 00:00:00

  • Moclobemide, an inhibitor of MAO-A, does not increase daytime plasma melatonin levels in normal humans.

    abstract：:1. Plasma melatonin concentrations were determined after administration of single oral doses (100, 200 and 300 mg) of moclobemide, a reversible inhibitor of monoamine oxidase (MAO) with predominant effects on the A-type of the enzyme, to eight young, healthy male volunteers in a double-blind, random-order, placebo-con...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0278-5846(90)90065-o

    authors： Scheinin M,Koulu M,Vakkuri O,Vuorinen J,Zimmer RH

    更新日期：1990-01-01 00:00:00

  • Prolactin and estradiol serum levels in unmedicated male paranoid schizophrenia patients.

    abstract：:There is evidence for the involvement of the endocrine system in schizophrenia. This involment was widely investigated in female patients. In the current study, we examined prolactin and estradiol serum levels in hospitalized unmedicated men with first-episode and recurrent schizophrenia and then tested possible corre...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.09.016

    authors： Segal M,Avital A,Berstein S,Derevenski A,Sandbank S,Weizman A

    更新日期：2007-03-30 00:00:00

  • A nicotinic receptor antagonist enhances the hypothermic response to a muscarinic agonist.

    abstract：:1. Chronic treatment with amitriptyline produces supersensitivity to the hypothermic effects of the muscarinic agonist oxotremorine. 2. Chronic treatment with amitriptyline also produces supersensitivity to the hypothermic effects of nicotine. 3. Oxotremorine and other naturally occurring muscarinic agonists are also ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(91)90029-z

    authors： Dilsaver SC,Majchrzak MJ,Snider RM,Davidson RK

    更新日期：1991-01-01 00:00:00

  • Vglut2 haploinsufficiency enhances behavioral sensitivity to MK-801 and amphetamine in mice.

    abstract：:Recently developed mouse models have implicated the vesicular glutamate transporter 2 (VGLUT2) in psychostimulant-induced hyperactivity, a behavioral assay that is often applied to evaluate mouse behavior related to positive schizophrenia (SCZ) symptomatology. In present research, we wanted to evaluate further the rol...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.03.023

    authors： Naert A,Callaerts-Vegh Z,Moechars D,Meert T,D'Hooge R

    更新日期：2011-07-01 00:00:00