当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > 5-HT1A receptor responsivity in anxiety disorders and depression.

5-HT1A receptor responsivity in anxiety disorders and depression.

Abstract：

:1. Azapirones, selective partial agonists at the 5-HT1A receptor subtype, induce hypothermia and corticotropin (ACTH)/cortisol release as specific functional correlates of central 5-HT1A receptor activation. 2. Compared to controls, hypothermic and ACTH/cortisol responses to the azapirone ipsapirone are attenuated in patients with unipolar depression and panic disorder but not in patients with obsessive-compulsive disorder. The impaired thermic and neuroendocrine responses are associated with increased basal cortisol secretion in depressed patients but not in patients with panic disorder. 3. Chronic treatment with the selective 5-HT reuptake inhibitor fluoxetine decreases 5-HT1A receptor-mediated responses in patients with obsessive-compulsive disorder, while long-term treatment with the tricyclic antidepressant amitriptyline further decreases hypothermia following ipsapirone but has no effect on ACTH/cortisol release. 4. Alteration of the 5-HT1A receptor and/or its signal transduction pathways may play a role in the pathophysiology and treatment of anxiety disorders and depression.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Lesch KP

doi

10.1016/0278-5846(91)90001-h

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

723-33

issue

6

eissn

0278-5846

issn

1878-4216

journal_volume

15

pub_type

杂志文章,评审

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Impaired pre-attentive auditory processing in opioid dependence with and without benzodiazepine co-dependence revealed by combined magnetoencephalography and electroencephalography.

    abstract：:Cognitive dysfunctions may be a significant factor in drug-seeking behavior, reducing the efficiency of rehabilitation in opioid dependence. Neurophysiological basis of these dysfunctions is poorly understood. 21 opioid-dependent patients and 15 healthy controls with no experience of illicit drugs were studied with si...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.06.001

    authors： Kivisaari R,Lehtinen R,Autti T,Puuskari V,Jokela O,Ahveninen J,Rapeli P,Kähkönen S

    更新日期：2007-10-01 00:00:00

  • Self-reported pain in patients with schizophrenia. Results from the national first-step FACE-SZ cohort.

    abstract：INTRODUCTION:Little is known about perception of physical pain in schizophrenia (SZ). Some studies have suggested that patients with SZ may have an increased pain threshold, while others have suggested that patients with SZ may suffer from undetected and untreated high physical pain levels. The objectives of this study...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.pnpbp.2018.04.007

    authors： Fond G,Boyer L,Andrianarisoa M,Godin O,Bulzacka E,Berna F,Brunel L,Coulon N,Aouizerate B,Capdevielle D,Chereau I,D'amato T,Denizot H,Dubertret C,Dubreucq J,Faget C,Leignier S,Mallet J,Misdrahi D,Rey R,Lancon C,P

    更新日期：2018-07-13 00:00:00

  • Is vitamin D hypothesis for schizophrenia valid? Independent segregation of psychosis in a family with vitamin-D-dependent rickets type IIA.

    abstract：:The vitamin D hypothesis of schizophrenia is a recent concept bringing together old observations on environmental risk factors and new findings on the neurodevelopmental effects of vitamin D. Candidate genes related to the vitamin D endocrine system have not yet been fully explored for this purpose. The coexistence of...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2003.10.002

    authors： Ozer S,Uluşahin A,Ulusoy S,Okur H,Coşkun T,Tuncali T,Göğüş A,Akarsu AN

    更新日期：2004-03-01 00:00:00

  • Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal.

    abstract：:1. Male hooded Lister rats were fed a liquid diet containing 10% absolute ethanol for 4-5 weeks. Control rats received the liquid diet in amounts controlled to produce equal weight gain. 2. The rats were tested 7.5 h after withdrawal of ethanol and 30 min after i.p. injection with nitrendipine, chlordiazepoxide or bac...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(92)90011-3

    authors： File SE,Zharkovsky A,Hitchcott PK

    更新日期：1992-01-01 00:00:00

  • Pramipexole for stage 2 treatment-resistant major depression: an open study.

    abstract：OBJECTIVE:To examine the effectiveness and safety of adjunctive pramipexole in the treatment of stage 2 treatment-resistant major depressive disorder. METHODS:This study included patients with moderate or non-psychotic severe major depressive disorder according to DSM-IV-TR criteria despite at least two adequate treat...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2010.07.035

    authors： Inoue T,Kitaichi Y,Masui T,Nakagawa S,Boku S,Tanaka T,Suzuki K,Nakato Y,Usui R,Koyama T

    更新日期：2010-12-01 00:00:00

  • Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients.

    abstract：:Ca(2+)-dependent activator protein for secretion 2 (CADPS2), a secretory granule associate protein, mediates monoamine transmission and the release of neurotrophins including brain-derived neurotrophic factor (BDNF) which have been implicated in psychiatric disorders. Furthermore, the expression of CADPS2deltaExon3, a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.05.004

    authors： Hattori K,Tanaka H,Wakabayashi C,Yamamoto N,Uchiyama H,Teraishi T,Hori H,Arima K,Kunugi H

    更新日期：2011-08-15 00:00:00

  • The effects of serotonin modulation on medial prefrontal connectivity strength and stability: A pharmacological fMRI study with citalopram.

    abstract：BACKGROUND:Static and dynamic functional connectivity are being increasingly used to measure the effects of disease and a range of different interventions on brain networks. While preliminary evidence suggests that static connectivity can be modulated by chronic antidepressants administration in healthy individuals and...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2018.01.021

    authors： Arnone D,Wise T,Walker C,Cowen PJ,Howes O,Selvaraj S

    更新日期：2018-06-08 00:00:00

  • Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment.

    abstract：:Kappa opioid receptors (KORs) in the central nervous system have been known to be important regulators of a variety of psychiatry illnesses, including anxiety and addiction, but their precise involvement in these disorders is complex and has yet to be fully elucidated. Here, we briefly review the pharmacology of KORs ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2015.01.001

    authors： Crowley NA,Kash TL

    更新日期：2015-10-01 00:00:00

  • Antidepressant-like synergism of extracts from magnolia bark and ginger rhizome alone and in combination in mice.

    abstract：:Magnolia bark and ginger rhizome is a drug pair in many prescriptions for treatment of mental disorders in traditional Chinese medicine (TCM). However, compatibility and synergism mechanism of two herbs on antidepressant actions have not been reported. The aim of this study was to approach the rationale of the drug pa...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.03.001

    authors： Yi LT,Xu Q,Li YC,Yang L,Kong LD

    更新日期：2009-06-15 00:00:00

  • Prefrontal brain metabolites in short-term weight-recovered adolescent anorexia nervosa patients.

    abstract：:Various neuroimaging techniques have revealed morphological and functional alterations in anorexia nervosa (AN), although few spectroscopic magnetic resonance studies have examined short-term weight-recovered AN patients. Subjects were 32 female adolescent patients (between 13 and 18 years old) seen consecutively in o...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2010.05.020

    authors： Castro-Fornieles J,Garcia AI,Lazaro L,Andrés-Perpiñá S,Falcón C,Plana MT,Bargallo N

    更新日期：2010-08-16 00:00:00

  • Effects of antidepressants on mRNA levels of antioxidant enzymes in human monocytic U-937 cells.

    abstract：:Alterations of antioxidant enzyme activities have been described in a number of psychiatric disorders including major depression. Subsequently, the present study examined the effects of different types of antidepressants (desipramine, imipramine, maprotiline and mirtazapine) in different concentrations (10(-5), 10(-6)...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2008.05.024

    authors： Schmidt AJ,Heiser P,Hemmeter UM,Krieg JC,Vedder H

    更新日期：2008-08-01 00:00:00

  • Melatonin treatment during the incubation of sensitization attenuates methamphetamine-induced locomotor sensitization and MeCP2 expression.

    abstract：:Behavior sensitization is a long-lasting enhancement of locomotor activity after exposure to psychostimulants. Incubation of sensitization is a phenomenon of remarkable augmentation of locomotor response after withdrawal and reflects certain aspects of compulsive drug craving. However, the mechanisms underlying these ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2015.09.008

    authors： Wu J,Zhu D,Zhang J,Li G,Liu Z,Sun J

    更新日期：2016-02-04 00:00:00

  • An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females.

    abstract：:The personality traits associated with the noradrenergic system have not yet been clearly established. In the present study, we investigated the variable number of tandem repeats (VNTR) polymorphism of the norepinephrine transporter (NET) and monoamine oxidase A (MAOA), which are major components of the adrenergic sys...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.08.014

    authors： Lee BC,Yang JW,Lee SH,Kim SH,Joe SH,Jung IK,Choi IG,Ham BJ

    更新日期：2008-01-01 00:00:00

  • The effect of age, sex, weight and height on the plasma concentrations in healthy subjects of the acidic metabolites of some biogenic monoamines involved in psychiatric and neurological disorders.

    abstract：:1. The plasma concentrations of unconjugated phenylacetic acid and m-hydroxyphenylacetic acid are lower in male than in female subjects. 2. The plasma concentrations of unconjugated phenylacetic acid and mandelic acid decrease with increasing weight and height for all subjects combined. The same relationships apply fo...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(91)90025-v

    authors： Davis BA,Durden DA,O'Reilly RL

    更新日期：1991-01-01 00:00:00

  • Buprenorphine treatment outcome in dually diagnosed heroin dependent patients: A retrospective study.

    abstract：:The present study compared retrospectively in a clinical non-experimental setting the efficacy of buprenorphine (BUP) in different subgroups of dually diagnosed and non-dually diagnosed opioid-dependent patients: all the subjects included in the study showed severe long-lasting heroin addiction and 68.4% were affected...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2005.10.007

    authors： Gerra G,Leonardi C,D'Amore A,Strepparola G,Fagetti R,Assi C,Zaimovic A,Lucchini A

    更新日期：2006-03-01 00:00:00

  • Pharmacotherapy for major depression in children and adolescents.

    abstract：:Major depression is a serious illness in children which adversely effects their social, academic, and emotional development. It is essential to identify safe and effective medication for the treatment of this disorder in youths. Only some selective serotonin reuptake inhibitors (citalopram, fluoxetine, sertraline) hav...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2005.03.005

    authors： Wagner KD

    更新日期：2005-06-01 00:00:00

  • Monoamine neurocircuitry in depression and strategies for new treatments.

    abstract：:Extensive studies showed that monoaminergic neurotransmission that involves serotonin (5-HT), norepinephrine (NE) and dopamine (DA) exerts major influence on brain circuits concerned by the regulation of mood, reactivity to psychological stress, self-control, motivation, drive, and cognitive performance. Antidepressan...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2013.04.009

    authors： Hamon M,Blier P

    更新日期：2013-08-01 00:00:00

  • Brain neuropeptides: changes by treatment with the convulsants pentylenetetrazole and bicuculline.

    abstract：:1. The effects of chemically induced convulsions, clinically similar to those elicited by electroconvulsive treatment (ECT), on brain regional distribution of neuropeptide Y-, neurokinin A-, substance P- and neurotensin-like immunoreactivities were studied in the rat. 2. Pentylenetetrazole (PTZ) and bicuculline (BIC) ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(92)90030-i

    authors： Stenfors C,Theodorsson E,Mathé AA

    更新日期：1992-09-01 00:00:00

  • Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice.

    abstract：OBJECTIVE:Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the pr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.08.010

    authors： Kiser DP,Popp S,Schmitt-Böhrer AG,Strekalova T,van den Hove DL,Lesch KP,Rivero O

    更新日期：2019-03-08 00:00:00

  • CCK modulation of cerebellar afferents: dopaminergic involvement.

    abstract：:1. Dopamine agonists and dopamine releasers act at the level of the striatum to activate a mossy fiber pathway which in turn increases cerebellar cGMP in the rodent. 2. CCK acts to both decrease basal cerebellar cGMP levels as well as to antagonize increases in cerebellar cGMP elicited by dopaminergic agonists and rel...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(89)90139-5

    authors： Wood PL

    更新日期：1989-01-01 00:00:00

  • Elevated 3,4-dihydroxyphenylethyleneglycol (DHPG) excretion in dexamethasone resistant depressed patients.

    abstract：:Urinary and plasma DHPG and MHPG were estimated in patients with MADD and showing DST non-suppression as compared to those with normal suppression. Day and night 12h urine collections and morning plasma samples were analyzed by GC-MS for total MHPG and DHPG and free MHPG levels. Urinary DHPG excretion was significantl...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(85)90036-3

    authors： Warsh JJ,Hasey G,Cooke RG,Stancer HC,Persad E,Jorna T,Godse DD

    更新日期：1985-01-01 00:00:00

  • A multilevel analysis of the influence of Apolipoprotein E genotypes on depressive symptoms in late-life moderated by the environment.

    abstract：OBJECTIVE:This study aimed to clarify the relationship between the APOE alleles and depressive symptoms of older adults, considering individual characteristics and the effect of neighborhood environment. METHODS:Using a multilevel, stratified sampling strategy, 500 elders were recruited from official household records...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.09.023

    authors： Yen YC,Rebok GW,Yang MJ,Lung FW

    更新日期：2008-02-15 00:00:00

  • Integrated genetic databases in the study of neuropsychiatric diseases: inborn errors of cerebral metabolic pathways?

    abstract：:1. Genetic databases are an expanding and readily accessible repository of information on the mapping and sequencing of the human genome, and that of other model organisms. The integration and application of this information to neuropsychiatric disease is illustrated using neuroendocrine and neuropharmacologic data, c...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(91)90078-f

    authors： Jaworski M,Edwards E

    更新日期：1991-01-01 00:00:00

  • Environmental enrichment improves cognitive deficits in Spontaneously Hypertensive Rats (SHR): relevance for Attention Deficit/Hyperactivity Disorder (ADHD).

    abstract：:The interaction between genes and environment seems to be relevant for the development of Attention Deficit/Hyperactivity Disorder (ADHD), one of the most prevalent childhood psychiatric diseases. The occurrence of ADHD is typically associated with poor academic performance, probably reflecting learning difficulties a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.06.012

    authors： Pamplona FA,Pandolfo P,Savoldi R,Prediger RD,Takahashi RN

    更新日期：2009-10-01 00:00:00

  • S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice.

    abstract：:S 47445 is a positive allosteric modulator of glutamate AMPA-type receptors that possesses procognitive, neurotrophic and enhancing synaptic plasticity properties. Its chronic administration promotes antidepressant- and anxiolytic-like effects in different rodent models of depression. We have evaluated the behavioral ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.04.005

    authors： Pilar-Cuellar F,Castro E,Bretin S,Mocaer E,Pazos Á,Díaz Á

    更新日期：2019-07-13 00:00:00

  • Biological markers in alcoholism.

    abstract：:The search for biological markers of a predisposition towards alcoholism is the result of data indicating that this disorder is genetically influenced. The present paper reviews some methodological considerations important for trait marker research in alcoholism. To date, the most promising results have come from stud...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(86)90073-4

    authors： Schuckit MA

    更新日期：1986-01-01 00:00:00

  • In vitro effects of melatonin on [3H]muscimol binding in rat brain.

    abstract：:The possible interaction of melatonin with the GABAergic system at the receptor level was investigated. The effect of melatonin on the binding of the GABA agonist, [3H]muscimol, in crude synaptic membrane preparations was assayed. In fresh membrane preparations, melatonin increased [3H]muscimol binding in the rat stri...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(84)90034-4

    authors： Coloma FM,Niles LP

    更新日期：1984-01-01 00:00:00

  • All-trans retinoic acid rescues memory deficits and neuropathological changes in mouse model of streptozotocin-induced dementia of Alzheimer's type.

    abstract：:Recent studies have revealed that aberrant vitamin A signaling may lead to memory deficits in rodents. Present study investigates the potential of all-trans-retinoic acid (ATRA) an agonist at retinoid acid family of receptors, in cognitive dysfunctions associated with experimental dementia. Streptozotocin (STZ) [3 mg/...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.09.012

    authors： Sodhi RK,Singh N

    更新日期：2013-01-10 00:00:00

  • Alterations of p75 neurotrophin receptor and Myelin transcription factor 1 in the hippocampus of perinatal phencyclidine treated rats.

    abstract：:Postnatal administration of phencyclidine (PCP) in rodents causes major disturbances to neurological processes resulting in severe modifications to normal behavioral traits into adulthood. It is routinely used to model psychiatric disorders such as schizophrenia, producing many of the dysfunctional processes in the br...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2015.06.003

    authors： Andrews JL,Newell KA,Matosin N,Huang XF,Fernandez-Enright F

    更新日期：2015-12-03 00:00:00

  • Sertraline and rapid eye movement sleep without atonia: an 8-week, open-label study of depressed patients.

    abstract：:Previous studies have reported that selective serotonin reuptake inhibitors (SSRIs) may induce or exacerbate rapid eye movement (REM) sleep without atonia (RSWA) and increase the risk of developing REM sleep behavior disorder (RBD). However, most of these studies are retrospective and cross-sectional and employed smal...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2013.08.010

    authors： Zhang B,Hao Y,Jia F,Tang Y,Li X,Liu W,Arnulf I

    更新日期：2013-12-02 00:00:00