Abstract：
:Nicotine consumption through smoking affects anxious states in humans. However, the precise role of nicotinic acetylcholine receptor (nAChR) circuitry in the regulation of anxiety remains elusive. The Lynx protein Lypd6 is highly enriched in synaptic loci and has been previously identified as an endogenous inhibitor of neuronal nAChR function in vitro. Here, we investigate the effect of Lypd6 in anxiety-related behaviour and examine the molecular underpinnings of its function in the brain. We employ the marble burying (MB) and elevated zero maze (EZM) tests in Lypd6 knock-out (KO) and wild-type (WT) mice and find that loss of Lypd6 leads to decreased digging behaviour in the MB test and increased time spent in the open area in the EZM test. Moreover, we demonstrate that acute nicotine administration reduces digging in the MB test in both KO and WT mice and further accentuates the inherent genotype difference. Using in vitro electrophysiology in dorsal raphe nuclei (DRN) neurons from Lypd6 KO mice, we show that nicotine-evoked whole-cell currents are enhanced in the absence of Lypd6. Collectively, these data are the first to indicate the involvement of Lypd6 in circuits associated with anxiety and suggest that a possible underlying neurobiological mechanism is the modulation of cholinergic responses in the DRN.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Arvaniti M,Polli FS,Kohlmeier KA,Thomsen MS,Andreasen JTdoi
10.1016/j.pnpbp.2017.11.025subject
Has Abstractpub_date
2018-03-02 00:00:00pages
86-94eissn
0278-5846issn
1878-4216pii
S0278-5846(17)30750-9journal_volume
82pub_type
杂志文章abstract：:Estimates of the reported prevalence of visual hallucinations in the elderly vary from study to study. The aim of the present investigation was to re-evaluate the prevalence of visual hallucinations in elderly psychiatric outpatients and to examine pertinent risk factors. One hundred and twenty-two elderly (> or =60 y...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2003.11.002
更新日期：2004-03-01 00:00:00
abstract：:1. Delta TSH, REM latency, 4 pm and 11 pm post-dexamethasone cortisol values were determined after a wash-out period in a group of 74 non-selected depressed patients who were diagnosed (according to RDC with the SADS) as follows: 46 definite and 10 probable MD, 4 minor and 14 intermittent depression. 2. These biologic...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/0278-5846(94)90106-6
更新日期：1994-09-01 00:00:00
abstract：:Several lines of evidence suggest that genetic factors might contribute to susceptibility to panic disorder. Our previous studies show that the brain-derived neurotrophic factor (BDNF) may play a role in the pathophysiology of major depressive disorders and eating disorders. Assuming that BDNF may be implicated in the...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2005.04.018
更新日期：2005-06-01 00:00:00
abstract：:1. It has been postulated that the interrelated processes of neurodegeneration, neuroplasticity, and neuroimmunological abnormalities may play a role in the pathophysiology of schizophrenia. Since, interleukins are produced in the central nervous system and have cytokine and growth promoting properties, they are an ob...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(93)90072-z
更新日期：1993-05-01 00:00:00
abstract：:1. Cyclothymia is characterized by pronounced but not debilitating shifts of moods often lasting approximately two to nine weeks. 2. It can be classified as a psychopathologic mood disorder on a continuum to Bipolar II, or as a chronobiologic rhythm similar to the circadian except on an infradian time scale. 3. A male...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0278-5846(96)00129-7
更新日期：1996-11-01 00:00:00
abstract：:Citalopram, a selective serotonin reuptake inhibitor (SSRI), has been used as a neuroendocrine probe to assess serotonin (5-HT) function in human subjects. In an effort to characterize the oral citalopram challenge, we hypothesized that oral racemic citalopram would increase plasma cortisol, prolactin and adrenocortic...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.pnpbp.2006.01.017
更新日期：2006-06-01 00:00:00
abstract：:1. High-resolution MRI scans were obtained from 35 relatively high-functioning persons with autism and 36 healthy controls, comparable in age, gender, and IQ. 2. Volumetric measurements were obtained from manual tracing of the bilateral caudate, putamen, and globus pallidus. 3. An increased volume of the caudate nucle...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0278-5846(99)00020-2
更新日期：1999-05-01 00:00:00
abstract：:Accumulating evidence supports the hypothesis that modulation of glutamatergic system via NMDA receptors and mGlu5 receptors might be an effective antidepressant therapy. However, clinical application of NMDA and mGlu5 antagonists in the therapy of depression is still an open question. In the present study we investig...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2012.05.015
更新日期：2012-10-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2019.109683
更新日期：2019-12-20 00:00:00
abstract：:1. The clinical literature regarding the effects of various psychotropic agents on self-injurious behavior is reviewed. Anecdotal reports, open trials and controlled studies are each reviewed. 2. The absence of controlled studies and the failure to distinguish self-injurious behaviors from other forms of aggression ar...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0278-5846(90)90093-v
更新日期：1990-01-01 00:00:00
abstract：:The present study investigated the role of mitogen-activated protein kinase (MAPK) in orofacial neuropathic pain following chronic constriction injury of the infraorbital nerve (ION-CCI). Experiments were carried out on male Sprague-Dawley rats weighing between 200 and 230 g. The ION was separated from adhering tissue...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2007.05.016
更新日期：2007-08-15 00:00:00
abstract：:1. An assay was developed using sucrose gradient purified platelet plasma membranes which allowed detection, for the first time in patients, of both super-high affinity (KD = 17 pM) and high affinity (KD = 1.7 nM) binding sites. 2. Limited Scatchard plot analyses were performed on platelet membranes from depressed pat...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(88)90113-3
更新日期：1988-01-01 00:00:00
abstract：:1. The authors examined the effect of acute alcohol consumption on a set of visual tasks: visual short term memory, depth perception, and attention. 2. In a repeated measurement design, thirteen subjects performed the tasks once sober and once intoxicated with 0.8 g/kg body weight pure ethanol in orange juice (33% alc...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0278-5846(99)00009-3
更新日期：1999-04-01 00:00:00
abstract：:1. Lidocaine has been extensively investigated as a potential neuroprotective drug against ischemia-induced neurodegeneration without reaching any satisfactory conclusion. 2. The present work evaluates the effect of lidocaine -17 microM- on the hypoxia-induced release of tritiated D-aspartate from rat striatal slices ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(95)00122-c
更新日期：1995-09-01 00:00:00
abstract：:It has been reported that personality traits are related to several neurotransmitters. However, the association between personality traits and the central nervous system remains unclear. In the present study, we investigated the relationships between a polymorphism involving a variable number of tandem repeats in the ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2008.09.012
更新日期：2008-12-12 00:00:00
abstract：:A number of neuroprotective effects of curcumin have been demonstrated in recent years. However, whether curcumin exerts any beneficial effects on age-related impaired cognition and memory has not been well characterized; nor was there any detailed data on the molecular pathways activated by curcumin. The present stud...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2013.05.001
更新日期：2013-08-01 00:00:00
abstract：:1. The acute effects of some of typical and atypical antipsychotic drugs on the dopamine release and metabolism in the dorsal striatum of freely moving rats were studied using transcerebral microdialysis technique. 2. Classical neuroleptic drugs haloperidol (0.05, 0.1 and 0.2 mg/kg), thioproperazine (0.1, 0.2 and 0.4 ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(95)00267-7
更新日期：1995-12-01 00:00:00
abstract：:Neuropsychological deficits, such as poor episodic memory, are consistent features of mild cognitive impairment and also that of early stage of dementia. The aim of the present study was to detect cognitive dysfunction among patients with Alzheimer's disease or with mild cognitive impairment (MCI), which refers to a t...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2007.01.011
更新日期：2007-04-13 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0278-5846(03)00153-2
更新日期：2003-09-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2009.07.029
更新日期：2009-11-13 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2020.110085
更新日期：2020-09-02 00:00:00
abstract：:The central levels of endogenous tryptophan metabolite kynurenic acid (KYNA), an antagonist of N-methyl-d-aspartate (NMDA) and alpha7-nicotinic receptors, affect glutamatergic and dopaminergic neurotransmission. Here, we demonstrate that selective agonists of beta(1)-receptors (xamoterol and denopamine), beta(2)-recep...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2009.02.002
更新日期：2009-04-30 00:00:00
abstract：:1. The development of endogenous cholecystokinin (CCK) effects on food intake was studied in normal and undernourished growing rats of postnatal day 1-22. 2. Food intake was estimated by recording the gain in body weight before weaning. 3. l-phenylalanine, a potent stimulant of endogenous CCK release, suppressed 30 mi...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(91)90071-8
更新日期：1991-01-01 00:00:00
abstract：:Ketamine has been available for approximately 50 years as an anesthetic agent. It is known to have potent effects on the central nervous system glutamatergic system, in particular blockade of N-methyl-D-aspartate (NMDA) receptors. Based upon pre-clinical evidence of involvement of the glutamatergic system in mood diso...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2015.01.002
更新日期：2016-01-04 00:00:00
abstract：:This study evaluated the overall effectiveness and tolerability of adjunctive quetiapine as a continuation therapy for the long-term treatment of bipolar mania. Twenty-three patients were enrolled in this study and received quetiapine add-on treatment in combination with their existing or new mood stabilizers. The cli...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.pnpbp.2005.04.024
更新日期：2005-06-01 00:00:00
abstract：:Neuroinflammatory changes have been demonstrated to be an important feature of Alzheimer's disease (AD); however, the exact role of neuroinflammation and its progression during disease is still not well understood. One of the main drivers of the neuroinflammatory process are microglial cells. Positron Emission Tomogra...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2017.05.007
更新日期：2018-01-03 00:00:00
abstract：:1. Phorbol 12-myristate-13-acetate (PMA), a protein kinase C activator, elevated cyclic AMP accumulation in EBV-transformed human B-lymphocytes, and potentiated isoproterenol-, prostaglandin- (PGE1), cholera toxin-, and forskolin-stimulated cyclic AMP accumulation. 2. The dopamine D1 receptor agonist, SKF38393 (10(-7)...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(95)00295-2
更新日期：1996-01-01 00:00:00
abstract：:Associations between attention deficit hyperactivity disorder (ADHD) and genetic polymorphisms in the dopamine receptors, transporter and metabolizing enzymes have been reported in different ethnic groups. Gene variants may affect disease outcome by acting synergistically or antagonistically and thus their combined ef...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2010.12.027
更新日期：2011-03-30 00:00:00
abstract：OBJECTIVES:Some studies find a relationship between certain personality traits, as impulsivity or sensation seeking, and caffeine consumption, but these studies do not consider the potential confounding effect of smoking on caffeine intake, a co-occurrence that has been well demonstrated in epidemiological and clinical...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2007.02.006
更新日期：2007-06-30 00:00:00
abstract：:The olfactory system is involved in sensory functions, emotional regulation and memory formation. Olfactory bulbectomy in rat has been employed as an animal model of depression for antidepressant discovery studies for many years. Olfaction is impaired in animals suffering from chronic stress, and patients with clinica...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2014.05.013
更新日期：2014-10-03 00:00:00
