当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Molecular basis of amyotrophic lateral sclerosis.

Molecular basis of amyotrophic lateral sclerosis.

Abstract：

:Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration with unclear etiology and no effective treatment to date. ALS is, however, increasingly recognized as a multisystem disorder associated with impaired cognition. The overlap between ALS and dementia at clinical, genetic and neuropathologic levels indicates a spectrum of clinical phenotypes that may include features of frontotemporal lobar degeneration (FTLD). Most cases of ALS are sporadic (SALS), but approximately 10% of all ALS cases are familial ALS (FALS). Mutations in the Cu/Zn superoxide dismutase-1 gene (SOD-1) occur in about 20% of FALS cases. Mutations in the TAR DNA-binding protein 43 gene (TARDBP or TDP-43) may occur in 3-4% of FALS cases, and less frequently, in FTLD. Recently, mutations in the fused in sarcoma/translation in liposarcoma gene (FUS/TLS) were identified as causing about 4-5% of FALS, SALS, and FTLD cases, but not SOD-1 ALS cases, indicating a pathogenic role of FUS, together with TDP-43, in possibly all types of ALS, except for SOD-1 linked ALS. TDP-43 and FUS have striking structural and functional similarities, most likely implicating altered RNA processing as a major event in ALS pathogenesis. Thus, TARDBP and FUS/TLS mutations define a novel class of neurodegenerative diseases called TDP-43- and FUS-proteinopathies, in which both misfolded proteins are novel targets for the development of therapeutics in this spectrum of diseases. However, SOD-1 linked ALS may have a pathogenic pathway distinct from other types of ALS.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Liscic RM,Breljak D

doi

10.1016/j.pnpbp.2010.07.017

subject

Has Abstract

pub_date

2011-03-30 00:00:00

pages

370-2

issue

2

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(10)00280-0

journal_volume

35

pub_type

杂志文章,评审

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • A new risk locus in the ZEB2 gene for schizophrenia in the Han Chinese population.

    abstract：:The ZEB2 gene encodes the Zinc Finger E-box binding protein. As a key regulator of epithelial mesenchymal differentiation, ZEB2 plays an important role in the pathogenesis of cancer, and its high level expression has been observed in glioma patients. Different mutations in this gene have been identified in patients wi...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2015.12.001

    authors： Khan RAW,Chen J,Wang M,Li Z,Shen J,Wen Z,Song Z,Li W,Xu Y,Wang L,Shi Y

    更新日期：2016-04-03 00:00:00

  • Cerebral glucose utilization and platelet mitochondrial complex I activity in schizophrenia: A FDG-PET study.

    abstract：:Altered cerebral energy metabolism and mitochondrial dysfunction in periphery and in brain are implicated in the pathophysiology of schizophrenia. This study investigated whether cerebral glucose metabolism (rCGM) abnormalities are linked to altered mitochondrial complex I activity in the periphery, in schizophrenia. ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.12.025

    authors： Ben-Shachar D,Bonne O,Chisin R,Klein E,Lester H,Aharon-Peretz J,Yona I,Freedman N

    更新日期：2007-05-09 00:00:00

  • The use of the zebrafish model in stress research.

    abstract：:The study of the causes and mechanisms underlying psychiatric disorders requires the use of non-human models for the test of scientific hypotheses as well as for use in pre-clinical drug screening and discovery. This review argues in favor of the use of zebrafish as a novel animal model to study the impact of early (s...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2010.10.010

    authors： Steenbergen PJ,Richardson MK,Champagne DL

    更新日期：2011-08-01 00:00:00

  • Effects of pertussis toxin on behavioral responses during different withdrawal periods from chronic cocaine treatment.

    abstract：:1. The role of Gi-proteins on cataleptic responses induced by SCH23390 and haloperidol in chronic cocaine-treated mice was examined by intracerebroventricullor (i.c. v.) and intravenous (i. v.) injections of pertussis toxin (PTX), which catalyzes adenosine diphosphate (ADP)-ribosylation of Gi-proteins. 2. In animals p...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(00)00134-2

    authors： Ushijima I,Mizuki Y,Kobayashi T,Aoki T,Suetsugi M,Usami K,Watanabe Y

    更新日期：2000-11-01 00:00:00

  • Litter has an effect on the behavioural changes caused by the administration of the nitric oxide synthase inhibitor NG-nitro-L-arginine and ethanol in mice.

    abstract：:The aim of the work was to study the effects of litter and the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) on the behaviour of mice after acute and chronic ethanol administration and withdrawal. Male outbred NIH/S mice, from 21 litters, were distributed among experimental groups and subjected t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.06.008

    authors： Okva K,Lang A,Pokk P,Väli M,Nevalainen T

    更新日期：2004-11-01 00:00:00

  • Differences of sympathetic and parasympathetic modulation in major depression.

    abstract：:Inconsistent results have been reported with respect to cardiac autonomic function in major depression. The aim of our study was to investigate autonomic function in various branches of the autonomic nervous system in order to better understand parasympathetic and sympathetic modulation in the disease. We investigated...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.07.009

    authors： Schumann A,Andrack C,Bär KJ

    更新日期：2017-10-03 00:00:00

  • Treadmill running frequency on anxiety and hippocampal adenosine receptors density in adult and middle-aged rats.

    abstract：:Physical exercise protocols have varied widely across studies raising the question of whether there is an optimal intensity, duration and frequency that would produce maximal benefits in attenuating symptoms related to anxiety disorders. Although physical exercise causes modifications in neurotransmission systems, the...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.10.015

    authors： Costa MS,Ardais AP,Fioreze GT,Mioranzza S,Botton PH,Portela LV,Souza DO,Porciúncula LO

    更新日期：2012-01-10 00:00:00

  • Effect of adolescent exposure to MDMA and cocaine on acquisition and reinstatement of morphine-induce CPP.

    abstract：:It is well known that an elevated percentage of ecstasy users also consume cocaine. Recently, it has been reported that a high frequency of heroin smokers first consumed heroin under the effects of ecstasy with the hope of reducing the stimulant effects of the latter drug. The aim of the present study was to evaluate ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.11.017

    authors： Daza-Losada M,Rodríguez-Arias M,Aguilar MA,Miñarro J

    更新日期：2008-04-01 00:00:00

  • Modulatory role of dopamine on excitatory amino acid receptors.

    abstract：:1. In extensively washed synaptic membrane preparations from rat prefrontal cortex, the "in vitro" addition of either the D1 (SKF 38393) or the D2 (LY 171555) specific agonists markedly decreased the apparent affinity of the NMDA receptor antagonist [3H]-MK801 specific binding. In the same membrane preparation, the co...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(96)00039-5

    authors： Gandolfi O,Dall'Olio R

    更新日期：1996-05-01 00:00:00

  • Benzodiazepines and beta-adrenergic binding to primary cultures of astrocytes and neurons.

    abstract：:Characteristics of primary cultures of neurons or of astrocytes are discussed which suggest that such cultures are appropriate models for their in vivo counterparts. Advantages or disadvantages of these cultures for studies of receptor binding are: Neuronal and astrocytic binding can be studied separately. Binding can...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90045-3

    authors： Hertz L,Bender AS,Richardson JS

    更新日期：1983-01-01 00:00:00

  • White matter structural alterations in pediatric obsessive-compulsive disorder: relation to symptom dimensions.

    abstract：UNLABELLED:The aims of this study were to identify gray matter (GM) and white matter (WM) volume abnormalities in pediatric obsessive-compulsive patients, to examine their relationship between these abnormalities and the severity of disorder, and to explore whether they could be explained by the different symptom dimen...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2014.06.009

    authors： Lázaro L,Ortiz AG,Calvo A,Ortiz AE,Moreno E,Morer A,Calvo R,Bargallo N

    更新日期：2014-10-03 00:00:00

  • A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers.

    abstract：:Even though 85% of adults drink caffeinated beverages daily, very limited studies on plasma caffeine concentration in the US population have been published. Smoking induces cytochrome P450 1A2 (CYP1A2), which is the main enzyme involved in caffeine metabolism. The current naturalistic pilot study explores plasma caffe...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(02)00348-2

    authors： de Leon J,Diaz FJ,Rogers T,Browne D,Dinsmore L,Ghosheh OH,Dwoskin LP,Crooks PA

    更新日期：2003-02-01 00:00:00

  • Postnatal development of parvalbumin immunoreactivity in axon terminals of basket and chandelier neurons in monkey neocortex.

    abstract：:1. Two classes of GABAergic inhibitory interneurons, chandelier and basket cells, are known regulators of pyramidal neurons. Parvalbumin (PV) a calcium binding protein, has been shown to be a marker for axon terminals of subpopulations of these interneurons. 2. Immunohistochemical methods were used in this study to ex...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(92)90084-r

    authors： Akil M,Lewis DA

    更新日期：1992-05-01 00:00:00

  • miR-182 (microRNA-182) suppression in the hippocampus evokes antidepressant-like effects in rats.

    abstract：:Depression is a serious and potentially life-threatening mental disorder with unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) and microRNAs (miRNAs) play critical roles in the etiology of depression. However, the molecular mechanisms are not fully understood. Expression of miR-1...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2015.09.004

    authors： Li Y,Li S,Yan J,Wang D,Yin R,Zhao L,Zhu Y,Zhu X

    更新日期：2016-02-04 00:00:00

  • Type A and B monoamine oxidase in glial cells in long-term culture.

    abstract：:Monoamine oxidase (MAO) in astroglial primary cultures increased during cell development. The enzyme activity towards type B substrate was further enhanced in cultures treated with 0.25 mM dibutyl cyclic AMP (dBcAMP), although dBcAMP (1 mM) does not effect MAO activity in vitro. It has been estimated that the dBcAMP t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90046-5

    authors： Yu PH,Hertz L

    更新日期：1983-01-01 00:00:00

  • Correlation of fluphenazine plasma levels versus clinical response in patients: a pilot study.

    abstract：:Five schizophrenic patients (diagnosed using Research Diagnostic Criteria) under treatment with intramuscular fluphenazine decanoate or oral fluphenazine dihydrochloride had serial plasma fluphenazine and plasma prolactin levels determined by a direct radioimmunoassay method. Clinical state was assessed utilizing the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90068-4

    authors： Dudley J,Rauw G,Hawes EM,Keegan DL,Midha KK

    更新日期：1983-01-01 00:00:00

  • Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol.

    abstract：:Post-mortem and in-vivo studies support the hypothesis that astrocytes might be involved in the pathogenesis of schizophrenia. To further substantiate this hypothesis two markers of astroglial activation (myo-inositol, S100B) acquired with independent methods ((1)H-MRS, quantitative immunoassay) were concomitantly mea...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.09.013

    authors： Rothermundt M,Ohrmann P,Abel S,Siegmund A,Pedersen A,Ponath G,Suslow T,Peters M,Kaestner F,Heindel W,Arolt V,Pfleiderer B

    更新日期：2007-03-30 00:00:00

  • Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder.

    abstract：:Linkage studies in bipolar disorder (BPD) suggest that a susceptibility locus exists on chromosome 18p11. The myo-inositol monophosphatase 2 gene (IMPA2) maps to this genomic region. Myo-inositol monophosphatase dephosphorylates inositol monophosphate, regenerating free inositol. Lithium, a common treatment for BPD, h...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.pnpbp.2010.08.015

    authors： Bloch PJ,Weller AE,Doyle GA,Ferraro TN,Berrettini WH,Hodge R,Lohoff FW

    更新日期：2010-12-01 00:00:00

  • Deficits in episodic memory and mental time travel in patients with post-traumatic stress disorder.

    abstract：:Post-traumatic stress disorder (PTSD) is characterized by impairments in mnestic functions, especially in the domain of episodic memory. These alterations might affect different aspects of episodic memory functioning. Here we tested PTSD patients and healthy controls (matched for age, sex and education) in a newly dev...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.12.014

    authors： Zlomuzica A,Woud ML,Machulska A,Kleimt K,Dietrich L,Wolf OT,Assion HJ,Huston JP,De Souza Silva MA,Dere E,Margraf J

    更新日期：2018-04-20 00:00:00

  • Limbic control of aggression in the cat.

    abstract：:Over a decade of work by Flynn and colleagues has delineated a network of limbic circuits which function to modulate the expression of predatory aggression and defence in the cat, and aspects of this work are reviewed. In particular, Flynn's work revealed a circuit involving the basomedial amygdala which functions to ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90017-9

    authors： Adamec RE,Stark-Adamec CI

    更新日期：1983-01-01 00:00:00

  • Increased frequency of T cells expressing IL-10 in Alzheimer disease but not in late-onset depression patients.

    abstract：:Higher risk of dementia is expected for patients with late onset depression (LOD) history. The IL-10 polymorphisms are associated with Alzheimer disease (AD). On the other hand, there is no study associating IL-10 polymorphisms to LOD. This study aimed to investigate the -1082G/A polymorphism association in LOD, AD pa...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2013.07.021

    authors： Torres KC,Araújo Pereira P,Lima GS,Bozzi IC,Rezende VB,Bicalho MA,Moraes EN,Miranda DM,Romano-Silva MA

    更新日期：2013-12-02 00:00:00

  • Is vitamin D hypothesis for schizophrenia valid? Independent segregation of psychosis in a family with vitamin-D-dependent rickets type IIA.

    abstract：:The vitamin D hypothesis of schizophrenia is a recent concept bringing together old observations on environmental risk factors and new findings on the neurodevelopmental effects of vitamin D. Candidate genes related to the vitamin D endocrine system have not yet been fully explored for this purpose. The coexistence of...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2003.10.002

    authors： Ozer S,Uluşahin A,Ulusoy S,Okur H,Coşkun T,Tuncali T,Göğüş A,Akarsu AN

    更新日期：2004-03-01 00:00:00

  • 5-HT2C receptors in psychiatric disorders: A review.

    abstract：:5-HT2Rs have a different genomic organization from other 5-HT2Rs. 5HT2CR undergoes post-transcriptional pre-mRNA editing generating diversity among RNA transcripts. Selective post-transcriptional editing could be involved in the pathophysiology of psychiatric disorders through impairment in G-protein interactions. Mor...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2015.12.006

    authors： Chagraoui A,Thibaut F,Skiba M,Thuillez C,Bourin M

    更新日期：2016-04-03 00:00:00

  • Bone density measurement in major depression.

    abstract：:1. Disturbances in cortisol secretory patterns and excessive secretion of cortisol after a variety of neuroendocrine stimulation tests indicate excessive activity of the hypothalamic-pituitary-adrenocortical axis in depression. 2. Peripheral indicators of hypercortisolemia have also been observed (e.g. enlarged adrena...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(98)00003-7

    authors： Amsterdam JD,Hooper MB

    更新日期：1998-02-01 00:00:00

  • Duration of transcranial magnetic stimulation effects on the neuroendocrine stress response and coping behavior of adult male rats.

    abstract：BACKGROUND:Transcranial magnetic stimulation (TMS) is a relatively novel, noninvasive method of altering cerebral electrophysiological activity that produces localized and reversible changes in brain tissue. TMS has been shown to have antidepressant properties in both human trials and animal models. Additionally, TMS m...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0278-5846(03)00052-6

    authors： Hedges DW,Massari C,Salyer DL,Lund TD,Hellewell JL,Johnson AC,Lephart ED

    更新日期：2003-06-01 00:00:00

  • Stereopsychopharmacology: past, present and future.

    abstract：:Stereoisomers have been used for more than a century to study the role of three-dimensional (spatial) features in biological processes. Configuration and conformation are spatial features of primary interest for effects of drugs. The role of configuration has been studied mainly by comparing effects of optical isomers...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：

    authors： Smith DF

    更新日期：1984-01-01 00:00:00

  • Cytoskeleton of hippocampal neurons as a target for valproic acid in an experimental model of depression.

    abstract：BACKGROUND:Atrophy of pyramidal hippocampal neurons and of the entire hippocampus has been reported in experimental models of depression and in depressive patients respectively. We investigated the efficacy of valproic acid (VPA) for reversing a depressive-like behaviour and a cytoskeletal alteration in the hippocampus...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.06.014

    authors： Ferrero AJ,Cereseto M,Sifonios LL,Reinés A,Peixoto E,Rubio MC,Wikinski S

    更新日期：2007-10-01 00:00:00

  • Skin conductance reaction (SCR)-habituation test, a tool to detect anxiolytic activity. Its justification by the correlation between SCR-habituation test activities and specific binding potencies in benzodiazepines.

    abstract：:Correlation between specific binding potencies "in vitro" of several benzodiazepines and activities in SCR-habituation test is very satisfactory. As the SCR-habituation test might be considered as an elementary model of anxiety state, the test is suggested to be used as an intermediate psychopharmacological tool befor...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(85)90191-5

    authors： Marcy R,Quermonne MA,Raoul J,Nammathao B,Smida A

    更新日期：1985-01-01 00:00:00

  • Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia.

    abstract：:CYP1A2 is an important inducible enzyme involved in the metabolism of antipsychotics. This study examined two functional polymorphisms in the gene as potential markers in predicting prolongation of QTc interval in patients treated with antipsychotics. QT intervals were measured by 12-lead electrocardiography (ECG) for...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.05.013

    authors： Tay JK,Tan CH,Chong SA,Tan EC

    更新日期：2007-08-15 00:00:00

  • Abnormal cerebral perfusion in chronic methamphetamine abusers: a study using 99MTc-HMPAO and SPECT.

    abstract：:1. Cerebral blood flow of nine methamphetamine abusers with technetium-99m-hexamethylpropyleneamine oxime (HMPAO) and single photon emission computed tomography (SPECT) as well as morphological examination with magnetic resonance imaging (MRI) were investigated. 2. Six of these subjects exhibited multiple focal perfus...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0278-5846(97)00079-1

    authors： Iyo M,Namba H,Yanagisawa M,Hirai S,Yui N,Fukui S

    更新日期：1997-07-01 00:00:00