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Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol.

Abstract：

:Post-mortem and in-vivo studies support the hypothesis that astrocytes might be involved in the pathogenesis of schizophrenia. To further substantiate this hypothesis two markers of astroglial activation (myo-inositol, S100B) acquired with independent methods ((1)H-MRS, quantitative immunoassay) were concomitantly measured in schizophrenic patients. Patients with increased S100B levels showed elevated myo-inositol concentrations. This pilot study demonstrates a concomitant elevation of two markers indicating astrocyte activation in a subgroup of schizophrenic patients.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Rothermundt M,Ohrmann P,Abel S,Siegmund A,Pedersen A,Ponath G,Suslow T,Peters M,Kaestner F,Heindel W,Arolt V,Pfleiderer B

doi

10.1016/j.pnpbp.2006.09.013

subject

Has Abstract

pub_date

2007-03-30 00:00:00

pages

361-4

issue

2

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(06)00352-6

journal_volume

31

pub_type

杂志文章

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