A review of pharmacological agents for self-injurious behavior.

Abstract:

:1. The clinical literature regarding the effects of various psychotropic agents on self-injurious behavior is reviewed. Anecdotal reports, open trials and controlled studies are each reviewed. 2. The absence of controlled studies and the failure to distinguish self-injurious behaviors from other forms of aggression are highlighted. 3. However, the review does raise the possibility that a wide range of agents may be useful for treating self-injurious behaviors and these appear to be similar to the agents used to treat other forms of aggression.

authors

Luchins DJ

doi

10.1016/0278-5846(90)90093-v

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

S169-79

eissn

0278-5846

issn

1878-4216

journal_volume

14 Suppl

pub_type

杂志文章,评审
  • Oscillatory potentials abnormalities in regular cannabis users: Amacrine cells dysfunction as a marker of central dopaminergic modulation.

    abstract:BACKGROUND:Cannabis is a neuromodulating substance that acts on central synaptic transmission. Regular cannabis use induces a decreased capacity for dopamine synthesis in the brain. The retina is considered an easy means of investigating dysfunctions of synaptic transmission in the brain. We have previously studied the...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2020.110083

    authors: Polli L,Schwan R,Albuisson E,Malbos L,Angioi-Duprez K,Laprevote V,Schwitzer T

    更新日期:2020-08-27 00:00:00

  • The NVL gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population.

    abstract::NVL (nuclear VCP (valosin containing protein)/p97-Like), a member of the AAA-ATPase (ATPases associated with various cellular activities) family, encodes a novel hTERT (human telomerase reverse transcriptase)-interacting protein NVL2 which is a telomerase component essential for holoenzyme assembly. Previous researche...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2015.04.001

    authors: Wang M,Chen J,He K,Wang Q,Li Z,Shen J,Wen Z,Song Z,Xu Y,Shi Y

    更新日期:2015-10-01 00:00:00

  • Effect of aging on the spatial learning deficit produced by diazepam in rats.

    abstract::1. After pretraining in an undrugged state, young (6 months) and aged (18-24 months) rats were trained on a spatial learning-set task after receiving one of four doses of diazepam (1, 2, 3 or 5 mg/kg) or the drug vehicle. The effects of 5 mg/kg of diazepam were also assessed on the spatial learning-set task one full h...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(96)00065-6

    authors: McNamara RK,Davis TM,Skelton RW

    更新日期:1996-07-01 00:00:00

  • The effect of haloperidol on met-enkephalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging.

    abstract::1. Haloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. 2. Haloperidol elevated the beta-end level in AL and CCK level in NIL in young rats only. 3. The SP content in NIL was decreased by haloperidol in all ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(95)00234-0

    authors: Lau SM,Tang F

    更新日期:1995-11-01 00:00:00

  • Antipsychotics and single-cell activity in the rat superior colliculus.

    abstract::Schizophrenic patients have problems with saccadic eye movements that can be characterized as a loss of control over the saccadic system. Preliminary clinical results suggest that antipsychotics can either disrupt or improve saccadic performance. The brain mechanism through which antipsychotics might affect saccades i...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(01)00276-7

    authors: Broerse A,Timmerman W,Westerink BH,Den Boer JA

    更新日期:2002-02-01 00:00:00

  • New insights into tardive dyskinesia genetics: Implementation of whole-exome sequencing approach.

    abstract::Tardive dyskinesia (TD) is an adverse movement disorder induced by chronic treatment with antipsychotics drugs. The contribution of common genetic variants to TD susceptibility has been investigated in recent years, but with limited success. The aim of the current study was to investigate the potential contribution of...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2019.109659

    authors: Alkelai A,Greenbaum L,Heinzen EL,Baugh EH,Teitelbaum A,Zhu X,Strous RD,Tatarskyy P,Zai CC,Tiwari AK,Tampakeras M,Freeman N,Müller DJ,Voineskos AN,Lieberman JA,Delaney SL,Meltzer HY,Remington G,Kennedy JL,Pulver AE,

    更新日期:2019-08-30 00:00:00

  • Self-reported pain in patients with schizophrenia. Results from the national first-step FACE-SZ cohort.

    abstract:INTRODUCTION:Little is known about perception of physical pain in schizophrenia (SZ). Some studies have suggested that patients with SZ may have an increased pain threshold, while others have suggested that patients with SZ may suffer from undetected and untreated high physical pain levels. The objectives of this study...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.pnpbp.2018.04.007

    authors: Fond G,Boyer L,Andrianarisoa M,Godin O,Bulzacka E,Berna F,Brunel L,Coulon N,Aouizerate B,Capdevielle D,Chereau I,D'amato T,Denizot H,Dubertret C,Dubreucq J,Faget C,Leignier S,Mallet J,Misdrahi D,Rey R,Lancon C,P

    更新日期:2018-07-13 00:00:00

  • Psychological traits and platelet monoamine oxidase activity in eating disorder patients: their relationship and stability.

    abstract::Self-reported behavior and attitudes towards eating [Eating Disorder Inventory-2; Garner DM (1991). Eating Disorder Inventory-2: Professional Manual. Odessa, Fl.: Psychological Assessment Resources; Estonian version Podar I, Hannus A, Allik J (1999). Personality and Affectivity Characteristics Associated With Eating D...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2006.06.025

    authors: Podar I,Jaanisk M,Allik J,Harro J

    更新日期:2007-01-30 00:00:00

  • Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder.

    abstract::In the present study, we tested the hypothesis that the potent and selective dopamine-β-hydroxylase (DβH) inhibitor nepicastat would have minimal effects on cardiovascular and pharmacokinetic parameters associated with cocaine administration and would reduce the positive subjective effects produced by cocaine. We cond...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.pnpbp.2015.01.009

    authors: De La Garza R 2nd,Bubar MJ,Carbone CL,Moeller FG,Newton TF,Anastasio NC,Harper TA,Ware DL,Fuller MA,Holstein GJ,Jayroe JB,Bandak SI,Reiman KZ,Neale AC,Pickford LB,Cunningham KA

    更新日期:2015-06-03 00:00:00

  • Verbal but not performance IQ is highly correlated to externalizing behavior in boys with ADHD carrying both DRD4 and DAT1 risk genotypes.

    abstract:OBJECTIVE:Attention-deficit/hyperactivity disorder (ADHD) is often associated with reduced IQ and high levels of externalizing behavior (EB). This study tested if DRD4 7-repeat allele and DAT1 10-repeat allele homozygosity interact in modulating correlations between IQ and EB in affected boys. METHODS:Boys (n=130) bet...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2009.04.019

    authors: Kebir O,Grizenko N,Sengupta S,Joober R

    更新日期:2009-08-31 00:00:00

  • Comparison of the efficacy between paroxetine and sertraline augmented with aripiprazole in patients with refractory major depressive disorder.

    abstract:OBJECTIVE:Only two-thirds of depressive patients respond to antidepressant treatment. In recent years, addition of an atypical antipsychotic drug to ongoing treatment with an antidepressant has been considered effective and well-tolerated. In the present study, we compared the efficacy between paroxetine and sertraline...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.pnpbp.2012.07.008

    authors: Yoshimura R,Kishi T,Hori H,Ikenouchi-Sugita A,Katsuki A,Umene-Nakano W,Iwata N,Nakamura J

    更新日期:2012-12-03 00:00:00

  • Impact of juvenile chronic stress on adult cortico-accumbal function: Implications for cognition and addiction.

    abstract::Repeated exposure to stress during childhood is associated with increased risk for neuropsychiatric illness, substance use disorders and other behavioral problems in adulthood. However, it is not clear how chronic childhood stress can lead to emergence of such a wide range of symptoms and disorders in later life. One ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2017.06.015

    authors: Watt MJ,Weber MA,Davies SR,Forster GL

    更新日期:2017-10-03 00:00:00

  • Right prefrontal function and coping strategies in patients with remitted major depressive disorder.

    abstract:BACKGROUND:Patients with remitted major depressive disorder (rMDD) generally rely on maladaptive coping strategies for stressful situations. These maladaptive copings are associated with an elevated relapse risk of rMDD; however, their neural basis remains poorly understood. METHODS:We enrolled (1) 45 patients with rM...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2020.110085

    authors: Tsujii N,Mikawa W,Adachi T,Sakanaka S,Shirakawa O

    更新日期:2020-09-02 00:00:00

  • Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke.

    abstract::Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2015.04.002

    authors: Walker-Batson D,Mehta J,Smith P,Johnson M

    更新日期:2016-01-04 00:00:00

  • Genome-wide association meta-analysis of cocaine dependence: Shared genetics with comorbid conditions.

    abstract::Cocaine dependence is a complex psychiatric disorder that is highly comorbid with other psychiatric traits. Twin and adoption studies suggest that genetic variants contribute substantially to cocaine dependence susceptibility, which has an estimated heritability of 65-79%. Here we performed a meta-analysis of genome-w...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.pnpbp.2019.109667

    authors: Cabana-Domínguez J,Shivalikanjli A,Fernàndez-Castillo N,Cormand B

    更新日期:2019-08-30 00:00:00

  • Cooperative interaction between the basolateral amygdala and ventral tegmental area modulates the consolidation of inhibitory avoidance memory.

    abstract::The aim of the current study was to examine the existence of a cooperative interaction between the basolateral nucleus of amygdala (BLA) and the ventral tegmental area (VTA) in inhibitory avoidance task. The BLA and the VTA regions of adult male Wistar rats were simultaneously cannulated and memory consolidation was m...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2012.10.003

    authors: Nazari-Serenjeh F,Rezayof A

    更新日期:2013-01-10 00:00:00

  • The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression [corrected].

    abstract::A great number of clinical observations show a relationship between epilepsy and depression. Idiopathic generalized epilepsy, including absence epilepsy, has a genetic basis. The review provides evidence that WAG/Rij rats can be regarded as a valid genetic animal model of absence epilepsy with comorbidity of depressio...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2010.11.010

    authors: Sarkisova K,van Luijtelaar G

    更新日期:2011-06-01 00:00:00

  • Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder.

    abstract:BACKGROUND:Neurological soft signs (NSS) are minor neurological abnormalities, including motor, sensory, and inhibitory dysfunction. Schizophrenia and other neuropsychiatric disorders are associated with a higher prevalence of NSS. However, the relationships between NSS and schizophrenia, bipolar disorder, and major de...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2012.12.006

    authors: Zhao Q,Ma YT,Lui SS,Liu WH,Xu T,Yu X,Tan SP,Wang ZR,Qu M,Wang Y,Huang J,Cheung EF,Dazzan P,Chan RC

    更新日期:2013-06-03 00:00:00

  • Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: inverse association with positive symptoms.

    abstract::Excessive free radical production or oxidative stress may be involved in the pathophysiology of schizophrenia as evidenced by increased superoxide dismutase (SOD) activities, a critical enzyme in the detoxification of superoxide radicals. This study compared plasma SOD activities in 78 never-medicated first-episode an...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2011.08.018

    authors: Wu Z,Zhang XY,Wang H,Tang W,Xia Y,Zhang F,Liu J,Fu Y,Hu J,Chen Y,Liu L,Chen DC,Xiu MH,Kosten TR,He J

    更新日期:2012-01-10 00:00:00

  • Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine.

    abstract::The serotonin 1B receptor (5-HT1B) is important to both the pathogenesis of major depressive disorder and the antidepressant effects of selective serotonin reuptake inhibitors. Although fluoxetine has been shown to be effective and safe in children and adolescents, not all patients experience a proper clinical respons...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2016.12.003

    authors: Gassó P,Rodríguez N,Blázquez A,Monteagudo A,Boloc D,Plana MT,Lafuente A,Lázaro L,Arnaiz JA,Mas S

    更新日期:2017-04-03 00:00:00

  • Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal.

    abstract::1. Male hooded Lister rats were fed a liquid diet containing 10% absolute ethanol for 4-5 weeks. Control rats received the liquid diet in amounts controlled to produce equal weight gain. 2. The rats were tested 7.5 h after withdrawal of ethanol and 30 min after i.p. injection with nitrendipine, chlordiazepoxide or bac...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(92)90011-3

    authors: File SE,Zharkovsky A,Hitchcott PK

    更新日期:1992-01-01 00:00:00

  • Facilitatory effects of chronically administered citicoline on learning and memory processes in the dog.

    abstract::1. Citicoline (cytidine (5') diphosphocholine) has been shown to reverse aging-induced memory deficits, scopolamine-induced amnesia and nucleus basalis magnocellularis lesion-induced learning impairment. 2. This study aimed to evaluate the effects of citicoline on learning and retrieval processes in a complex differen...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0278-5846(97)00183-8

    authors: Bruhwyler J,Liégeois JF,Géczy J

    更新日期:1998-01-01 00:00:00

  • Staging and profiling for schizophrenia spectrum disorders: Inter-rater reliability after a short training course.

    abstract:OBJECTIVE:Clinical staging and profiling have been proposed as a new approach in order to refine the diagnostic assessment of schizophrenia spectrum disorders. However, only limited evidence is available for the inter-rater reliability of the clinical staging and profiling model. The aim of the present study was theref...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2019.109856

    authors: Berendsen S,van der Paardt JW,Van HL,van Bruggen M,Nusselder H,Jalink M,de Peuter OR,Peen J,van Tricht MJ,de Haan L

    更新日期:2020-04-20 00:00:00

  • The dopamine and serotonin systems during aging in human and rodent brain. A brief review.

    abstract::During nonpathological aging, quantitative changes occur in the pre- and post-synaptic elements of both the dopamine and serotonin systems. The level of dopamine in the human striatum declines up to 50% with age, while smaller and more variable changes are found in rodent brain (0-30%). Postsynaptically, the density o...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(87)90053-4

    authors: Morgan DG

    更新日期:1987-01-01 00:00:00

  • Molecular basis of amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal disorder of motor neuron degeneration with unclear etiology and no effective treatment to date. ALS is, however, increasingly recognized as a multisystem disorder associated with impaired cognition. The overlap between ALS and dementia at clinical, genetic and neuropathol...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2010.07.017

    authors: Liscic RM,Breljak D

    更新日期:2011-03-30 00:00:00

  • Shared and distinct white matter abnormalities in schizophrenia and bipolar disorder.

    abstract::While white matter impairments play an integral part in the pathophysiology of schizophrenia and bipolar disorder, the literature on white matter abnormality differences between the two disorders is insufficient. The University of California Los Angeles Consortium for Neuropsychiatric Phenomic LA5c public dataset, inc...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2020.110175

    authors: Joo SW,Kim H,Jo YT,Yoon W,Kim Y,Lee J

    更新日期:2020-11-12 00:00:00

  • Glucocorticoids, genes and brain function.

    abstract::The identification of key genes in transcriptomic data constitutes a huge challenge. Our review of microarray reports revealed 88 genes whose transcription is consistently regulated by glucocorticoids (GCs), such as cortisol, corticosterone and dexamethasone, in the brain. Replicable transcriptomic data were combined ...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.pnpbp.2017.11.020

    authors: Juszczak GR,Stankiewicz AM

    更新日期:2018-03-02 00:00:00

  • Competition for sucrose-pellets in triads of male Wistar rats: effects of three serotonergic drugs.

    abstract::1. Within triads of rats, individuals can be discerned according to their competition for sucrose-pellets as a high-, a medium- and a poor-performing animal. 2. The competition-rates, expressed as scores, are affected by serotonergic drugs: upon inhibiting tryptophan-hydroxylase, the characteristic abstention of the p...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0278-5846(88)90009-7

    authors: Gentsch C,Lichtsteiner M,Feer H

    更新日期:1988-01-01 00:00:00

  • Delusional infestation: neural correlates and antipsychotic therapy investigated by multimodal neuroimaging.

    abstract:INTRODUCTION:In delusional infestation (DI), as with other non-schizophrenic psychotic disorders, little is known about the neural basis and the mechanisms of antipsychotic treatment. We aimed at investigating the brain circuitry involved in DI and the role of postsynaptic D2 receptors in mediating the effects of antip...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2010.06.022

    authors: Freudenmann RW,Kölle M,Huwe A,Luster M,Reske SN,Huber M,Lepping P,Wolf RC,Schönfeldt-Lecuona C

    更新日期:2010-10-01 00:00:00

  • Serotonin 2C receptor antagonist improves fear discrimination and subsequent safety signal recall.

    abstract:UNLABELLED:The capacity to discriminate between safety and danger is fundamental for survival, but is disrupted in individuals with posttraumatic stress disorder (PTSD). Acute stressors cause a release of serotonin (5-HT) in the forebrain, which is one mechanism for enhanced fear and anxiety; these effects are mediated...

    journal_title:Progress in neuro-psychopharmacology & biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.pnpbp.2015.08.017

    authors: Foilb AR,Christianson JP

    更新日期:2016-02-04 00:00:00