Abstract：
:1. Haloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. 2. Haloperidol elevated the beta-end level in AL and CCK level in NIL in young rats only. 3. The SP content in NIL was decreased by haloperidol in all age groups. 4. With regard to the effect of aging, Met-enk level in AL of middle-aged rats was higher than that in young rats. The beta-end level in AL also increased in old rats. 5. Aging modified the haloperidol effect on beta-end level in AL and CCK level in NIL as the effect was only observed in young rats. 6. In addition, aging caused a blunted response of Met-enk level to haloperidol in the striatum but an increased response of SP content to haloperidol in the NIL.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Lau SM,Tang Fdoi
10.1016/0278-5846(95)00234-0subject
Has Abstractpub_date
1995-11-01 00:00:00pages
1163-75issue
7eissn
0278-5846issn
1878-4216pii
0278584695002340journal_volume
19pub_type
杂志文章abstract：:1. The available evidence suggests that stress induced release of acetylcholine (ACh) in the brain has a significant role in mediating neuroendocrine, emotional, and physiological responses to stress. Recent findings also suggest that stress indirectly (via acetylcholine) and nicotine directly stimulates the HPA axis ...
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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