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Causal effects of serum metabolites on amyotrophic lateral sclerosis: A Mendelian randomization study.

Abstract：

:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that is affected by both genetic and environmental factors. Nowadays, OMIC technologies, such as genomics and metabolomics, are providing a systematic readout of genetic structures and physiological states for understanding human diseases. However, the comprehensive analysis of cross-omics is often lacking. Here, we conducted a Mendelian randomization analysis to provide a comprehensive analysis of metabolomics and genomics to estimate the causal relationships between non-targeted human serum metabolites and the development of ALS. Using genetic variants as predictors, our study detected 18 metabolites that might have causal effects on the development of ALS, including a group of gamma-glutamyl amino acids. Our findings suggested that glutathione metabolism dysfunction might be involved in the pathogenesis of ALS. Furthermore, our study provides a novel method to understand the pathogenesis of human diseases and develop therapeutic strategies for diseases by combining metabolomics with genomics.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Yang L,Lv X,Du H,Wu D,Wang M

doi

10.1016/j.pnpbp.2019.109771

subject

Has Abstract

pub_date

2020-03-08 00:00:00

pages

109771

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(19)30655-4

journal_volume

97

pub_type

杂志文章

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