当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Verbal but not performance IQ is highly correlated to externalizing behavior in boys with ADHD carrying both DRD4 and DAT1 risk genotypes.

Verbal but not performance IQ is highly correlated to externalizing behavior in boys with ADHD carrying both DRD4 and DAT1 risk genotypes.

Abstract：

OBJECTIVE:Attention-deficit/hyperactivity disorder (ADHD) is often associated with reduced IQ and high levels of externalizing behavior (EB). This study tested if DRD4 7-repeat allele and DAT1 10-repeat allele homozygosity interact in modulating correlations between IQ and EB in affected boys. METHODS:Boys (n=130) between 6 and 12 years of age diagnosed with ADHD were included in the study. IQ and EB were assessed by WISC-III and Child Behavioral Checklist, respectively. The 40 bp variable number tandem repeat (VNTR) of the DAT1 gene and the 48 bp VNTR of the DRD4 gene polymorphisms were genotyped and 4 subgroups were defined by the presence/absence of the DRD4 7-repeat allele and by the presence/absence of the DAT1 10/10 genotype. Correlation coefficients were compared using the Fisher's Z transformation and regression lines by a Potthoff analysis. RESULTS:In the total sample, all correlation coefficients between EB score and IQ were non significant. Also, no differences in IQ were observed between the 4 genotype groups. However, different pattern of correlations between IQ and EB score appeared. In boys carrying no or only one genetic risk, IQ and EB score were uncorrelated while in children carrying both risk factors, negative and significant correlations emerged. Notably, correlation of EB to verbal IQ was strong (r=-0.71) and highly significant (P<0.01) in boys carrying both risk alleles. All pair-wise comparisons of correlation coefficients were significant for EB-verbal IQ correlation. Test of coincidence of regression lines did not show significant differences. CONCLUSIONS:A specific domain of IQ, namely the verbal quotient is highly correlated to the level of EB in boys with ADHD carrying both dopaminergic risk genotypes. Further investigations are required to replicate these results and determine specificity to ADHD.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Kebir O,Grizenko N,Sengupta S,Joober R

doi

10.1016/j.pnpbp.2009.04.019

subject

Has Abstract

pub_date

2009-08-31 00:00:00

pages

939-44

issue

6

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(09)00148-1

journal_volume

33

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status.

    abstract：:Dietary antioxidants might exert an important role in the aging process by relieving oxidative damage, a likely cause of age-associated brain dysfunctions. This study aims to investigate the influence of esculetin (6,7-dihydroxycoumarin), a naturally occurring antioxidant in the diet, on mood-related behaviors and cog...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2015.08.007

    authors： Martín-Aragón S,Villar Á,Benedí J

    更新日期：2016-02-04 00:00:00

  • Risperidone in the treatment of psychotic depression.

    abstract：:In the preset study, the authors investigated that effects of the antipsychotic drug risperidone on psychotic depression and examined the mechanism of risperidone to ameliorate psychotic depression. Fifteen patients met the DSM-IV criteria for major depressive disorder with psychotic features and the remaining five pa...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2006.01.016

    authors： Goto M,Yoshimura R,Kakihara S,Shinkai K,Yamada Y,Kaji K,Ueda N,Nakamura J

    更新日期：2006-06-01 00:00:00

  • Environmental enrichment improves cognitive deficits in Spontaneously Hypertensive Rats (SHR): relevance for Attention Deficit/Hyperactivity Disorder (ADHD).

    abstract：:The interaction between genes and environment seems to be relevant for the development of Attention Deficit/Hyperactivity Disorder (ADHD), one of the most prevalent childhood psychiatric diseases. The occurrence of ADHD is typically associated with poor academic performance, probably reflecting learning difficulties a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.06.012

    authors： Pamplona FA,Pandolfo P,Savoldi R,Prediger RD,Takahashi RN

    更新日期：2009-10-01 00:00:00

  • Effects of antidepressants on uptake and receptor systems in the brain.

    abstract：:Many antidepressant drugs inhibit the neuronal uptake of norepinephrine, serotonin, epinephrine and/or dopamine. Some newer antidepressant drugs are highly selective in their ability to inhibit the uptake of one or more of these monoamines. This uptake inhibition, which would be expected to increase the synaptic conce...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(85)90006-5

    authors： Fuller RW,Wong DT

    更新日期：1985-01-01 00:00:00

  • Differential roles of phospholipases A2 in neuronal death and neurogenesis: implications for Alzheimer disease.

    abstract：:The involvement of phospholipase A(2) (PLA(2)) in Alzheimer disease (AD) was first investigated nearly 15 years ago. Over the years, several PLA(2) isoforms have been detected in brain tissue: calcium-dependent secreted PLA(2) or sPLA(2) (IIA, IIC, IIE, V, X, and XII), calcium-dependent cytosolic PLA(2) or cPLA(2) (IV...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2010.08.019

    authors： Schaeffer EL,da Silva ER,Novaes Bde A,Skaf HD,Gattaz WF

    更新日期：2010-12-01 00:00:00

  • Intracisternal administration of COX inhibitors attenuates mechanical allodynia following compression of the trigeminal ganglion in rats.

    abstract：:The purpose of the present study was to investigate the role of central cyclooxygenase (COX) pathways in the modulation of mechanical allodynia following compression of the left trigeminal ganglion. Experiments were carried out on male Sprague-Dawley rats mounted onto a stereotaxic frame under anesthesia. For compress...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.02.010

    authors： Yang GY,Lee MK,Bae YC,Ahn DK

    更新日期：2009-06-15 00:00:00

  • Effects of antidepressants on entrainment of circadian rhythms.

    abstract：:1. Anti-depressant drugs alter the period of circadian rhythms under free running conditions. We have examined whether treatment with anti-depressants alters such rhythms under conditions of entrainment to a lighting cycle or following a phase advance of the lighting. 2. In the first experiment, following entrainment ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(88)90048-6

    authors： Brown GM,Seggie J

    更新日期：1988-01-01 00:00:00

  • Type A and B monoamine oxidase in glial cells in long-term culture.

    abstract：:Monoamine oxidase (MAO) in astroglial primary cultures increased during cell development. The enzyme activity towards type B substrate was further enhanced in cultures treated with 0.25 mM dibutyl cyclic AMP (dBcAMP), although dBcAMP (1 mM) does not effect MAO activity in vitro. It has been estimated that the dBcAMP t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90046-5

    authors： Yu PH,Hertz L

    更新日期：1983-01-01 00:00:00

  • Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations.

    abstract：:Most antipsychotics were thought to induce antipsychotic action at an excess of 70% striatal dopamine D2 receptor occupancy, while the clinical dose of clozapine was reported to show less than 60% occupancy. High-dose clozapine could occupy as high as 80% of striatal dopamine D2 receptor in monkey PET studies. Althoug...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2005.06.011

    authors： Takano A,Suhara T,Kusumi I,Takahashi Y,Asai Y,Yasuno F,Ichimiya T,Inoue M,Sudo Y,Koyama T

    更新日期：2006-01-01 00:00:00

  • Neural correlates of impaired emotional discrimination in borderline personality disorder: an fMRI study.

    abstract：:A common approach to study neuronal aspects of emotional reactivity of borderline personality disorder (BPD) is to study the brain response to emotional faces with functional magnetic resonance imaging (fMRI). 10 BPD patients and 10 matched controls were submitted to an emotional discrimination task in which subjects ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.08.022

    authors： Guitart-Masip M,Pascual JC,Carmona S,Hoekzema E,Bergé D,Pérez V,Soler J,Soliva JC,Rovira M,Bulbena A,Vilarroya O

    更新日期：2009-11-13 00:00:00

  • Neurocognitive endophenotypes in schizophrenia: modulation by nicotinic receptor systems.

    abstract：:Cigarette smoking is the leading preventable cause of death in the Western world, with a considerably higher prevalence observed in schizophrenia compared to the general population. Despite the negative health consequences of smoking heavily, it has been proposed that individuals with schizophrenia may maintain smokin...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2013.07.010

    authors： Mackowick KM,Barr MS,Wing VC,Rabin RA,Ouellet-Plamondon C,George TP

    更新日期：2014-07-03 00:00:00

  • Neurocognitive function in borderline personality disorder.

    abstract：:A battery of neuropsychological measures considered sensitive to dysfunction in prefrontal or temporal cortices was administered to patients with borderline personality disorder (BPD) and healthy controls. BPD patients exhibited striking deficits on measures of nonverbal executive function and nonverbal memory but wer...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2003.10.012

    authors： Dinn WM,Harris CL,Aycicegi A,Greene PB,Kirkley SM,Reilly C

    更新日期：2004-03-01 00:00:00

  • Effects of chronic nicotine on the temporal structure of anxiety-related behavior in rats tested in hole-board.

    abstract：:The present study aimed to assess the behavioral effects of chronic treatments of different doses of nicotine by using both quantitative and multivariate T-pattern analysis (TPA), which can reveal hidden behavioral structures, in Sprague-Dawley rats tested in the hole-board apparatus. To this purpose, nicotine ditartr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109731

    authors： Casarrubea M,Pierucci M,Aiello S,Cassar D,Deidda G,Crescimanno G,Di Giovanni G

    更新日期：2020-01-10 00:00:00

  • Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers.

    abstract：:People with Huntington's disease (HD) exhibit altered processing of emotional information, especially disgust and other negative emotions. These impairments are likely due to the effects of the disease on underlying brain networks. We examined whether oxytocin, when given intranasally, would normalise aberrant brain r...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.09.023

    authors： Labuschagne I,Poudel G,Kordsachia C,Wu Q,Thomson H,Georgiou-Karistianis N,Stout JC

    更新日期：2018-02-02 00:00:00

  • Neural substrates of opiate reinforcement.

    abstract：:A major component of opiate reward is derived from a drug action in the ventral tegmental area: (a) rats quickly learn to self-administer morphine directly into the ventral tegmentum, (b) intracranial self-administration into other brain sites is not quickly learned, and (c) narcotic antagonist microinjections into th...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90027-1

    authors： Bozarth MA,Wise RA

    更新日期：1983-01-01 00:00:00

  • Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: inverse association with positive symptoms.

    abstract：:Excessive free radical production or oxidative stress may be involved in the pathophysiology of schizophrenia as evidenced by increased superoxide dismutase (SOD) activities, a critical enzyme in the detoxification of superoxide radicals. This study compared plasma SOD activities in 78 never-medicated first-episode an...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.08.018

    authors： Wu Z,Zhang XY,Wang H,Tang W,Xia Y,Zhang F,Liu J,Fu Y,Hu J,Chen Y,Liu L,Chen DC,Xiu MH,Kosten TR,He J

    更新日期：2012-01-10 00:00:00

  • Neurophysiological maturation deficit in behaviour disorder of children--an electrographic study.

    abstract：:1. The investigations in biological factors of childrens' behaviour disorder are becoming increasingly important as their significance in clinical management is being recognized with more precision and clarity. 2. One of such electroencephalographic investigations is finding of some delay or defect in chronological ma...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(82)80145-0

    authors： Singh AN

    更新日期：1982-01-01 00:00:00

  • Lurasidone in post-menopausal females with major depressive disorder with mixed features: Post-hoc analysis of a placebo-controlled trial.

    abstract：BACKGROUND:Several studies have found that depressed, post-menopausal females may respond differently to antidepressants compared to pre-menopausal females. The atypical antipsychotic lurasidone, whose mechanism of action differs from SSRIs and other standard antidepressants, was shown in a 6-week randomized, flexible-...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2017.05.002

    authors： Sramek J,Loebel A,Murphy M,Mao Y,Pikalov A,Cutler NR

    更新日期：2017-08-01 00:00:00

  • Lidocaine reduces the hypoxia-induced release of an excitatory amino acid analog from rat striatal slices in superfusion.

    abstract：:1. Lidocaine has been extensively investigated as a potential neuroprotective drug against ischemia-induced neurodegeneration without reaching any satisfactory conclusion. 2. The present work evaluates the effect of lidocaine -17 microM- on the hypoxia-induced release of tritiated D-aspartate from rat striatal slices ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(95)00122-c

    authors： Díaz L,Gómez A,Bustos G

    更新日期：1995-09-01 00:00:00

  • Monitoring of haloperidol serum levels and it's clinical significance.

    abstract：:Haloperidol serum levels were determined by the recently developed radioimmunoassay technique to elucidate the relationship between serum levels and clinical effects and that between serum levels and adverse effects. The serum levels of haloperidol in divided daily doses schedule reached to the steady state more rapid...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(84)90135-0

    authors： Itoh H,Yagi G,Tateyama M,Fujii Y,Iwamura K,Ichikawa K

    更新日期：1984-01-01 00:00:00

  • Using model fish to study the biological mechanisms of cooperative behaviour: A future for translational research concerning social anxiety disorders?

    abstract：:Human societies demand of its composing members the development of a wide array of social tools and strategies. A notable example is human outstanding ability to cooperate with others, in all its complex forms, depicting the reality of a highly demanding social framework in which humans need to be integrated as to att...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2017.11.014

    authors： Soares MC,Cardoso SC,Carvalho TDS,Maximino C

    更新日期：2018-03-02 00:00:00

  • A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder.

    abstract：:Lithium is one of the most commonly used drugs for the treatment of bipolar disorder. To prescribe lithium appropriately to patients, predictors of response to this drug were explored, and several genetic markers are considered to be good candidates. We previously reported a significant association between genetic var...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2007.08.010

    authors： Masui T,Hashimoto R,Kusumi I,Suzuki K,Tanaka T,Nakagawa S,Suzuki T,Iwata N,Ozaki N,Kato T,Takeda M,Kunugi H,Koyama T

    更新日期：2008-01-01 00:00:00

  • Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice.

    abstract：:Following chronic administration of morphine a locomotor sensitization is usually observed. This behavioral sensitization is influenced by numerous factors including the administration pattern. While methadone and buprenorphine are the two main treatments for opioid dependence, literature about their ability to promot...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.10.013

    authors： Allouche S,Le Marec T,Noble F,Marie N

    更新日期：2013-01-10 00:00:00

  • Effects of antidepressants on mRNA levels of antioxidant enzymes in human monocytic U-937 cells.

    abstract：:Alterations of antioxidant enzyme activities have been described in a number of psychiatric disorders including major depression. Subsequently, the present study examined the effects of different types of antidepressants (desipramine, imipramine, maprotiline and mirtazapine) in different concentrations (10(-5), 10(-6)...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2008.05.024

    authors： Schmidt AJ,Heiser P,Hemmeter UM,Krieg JC,Vedder H

    更新日期：2008-08-01 00:00:00

  • Clinical clues to the aetiology of puerperal psychosis.

    abstract：:Recent case reports of postpartum psychosis are reviewed, which suggest hypotheses for the aetiology of this disease. The main themes are: The relationship to manic depression. Premenstrual relapse. Prepartum onset. Onset after miscarriage or evacuation of a trophoblastic tumour. Onset after bromocriptine treatment. A...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(94)90001-9

    authors： Brockington IF,Meakin CJ

    更新日期：1994-05-01 00:00:00

  • Alterations of synaptic high and low affinity opiate binding sites after acute and chronic morphine administration in mice.

    abstract：:1. The opiate receptor binding to whole brain synaptic membranes obtained from mice subjected to acute and chronic morphine administration and precipitated withdrawal was investigated. 2. The number of high and low affinity binding sites was significantly higher in morphine tolerant group than in control; acute admini...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(82)80187-5

    authors： Sivam SP,Nabeshima T,Ho IK

    更新日期：1982-01-01 00:00:00

  • Quetiapine for the treatment of borderline personality disorder; an open-label study.

    abstract：PURPOSE:Only a few studies have commented on the use of atypical antipsychotics for the treatment of Borderline Personality Disorder (BPD) features, including affective dysregulation and aggression. We aimed at evaluating both efficacy and safety of quetiapine in a sample of consecutive BPD patients. GENERAL METHODS:2...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.08.012

    authors： Perrella C,Carrus D,Costa E,Schifano F

    更新日期：2007-01-30 00:00:00

  • Association between TNF-α promoter -308A/G polymorphism and tardive dyskinesian Chinese Han patients with schizophrenia.

    abstract：OBJECTIVE:Previous studies have indicated that the immune may be involved in the pathogenesis of tardive dyskinesia (TD). Some genetic polymorphisms in the human leukocyte antigen (HLA) I and II regions have been associated with TD, and the tumor necrosis factor-α (TNF-α) gene is located in the HLA III region. TNF-α le...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.12.007

    authors： Wang F,Fan H,Sun H,Yang F,Luo Y,Liu H,Kosten TR,Lu L,Zhang XY

    更新日期：2012-04-27 00:00:00

  • VEGF serum levels in depressed patients during SSRI antidepressant treatment.

    abstract：:Recent evidence indicates that the vascular endothelial growth factor (VEGF) may be involved in the neuronal mechanisms underlying both the depression aetiology and the response to pharmacological and non pharmacological antidepressant treatments. To investigate whether VEGF peripheral levels are altered in depression...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2008.11.009

    authors： Ventriglia M,Zanardini R,Pedrini L,Placentino A,Nielsen MG,Gennarelli M,Bocchio-Chiavetto L

    更新日期：2009-02-01 00:00:00

  • A monoamine oxidase B gene variant and short-term antidepressant treatment response.

    abstract：:Genetic differences among patients suffering from Major Depression are likely to contribute to interindividual differences in medication treatment response. Thus, the identification of gene variants affecting drug response is needed in order to be able to predict response to psychopharmacological drugs. This study ana...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2007.05.015

    authors： Tadić A,Rujescu D,Müller MJ,Kohnen R,Stassen HH,Dahmen N,Szegedi A

    更新日期：2007-10-01 00:00:00