当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Expression of cannabinoid receptors and their gene transcripts in human blood cells.

Expression of cannabinoid receptors and their gene transcripts in human blood cells.

Abstract：

:1. This study shows that the human cannabinoid receptors and their gene transcripts can be analyzed in blood samples when combined with polymerase chain reaction. The results also demonstrate that the expression of the cannabinoid receptors is dependent on gender and ethnic background. 2. Normal human volunteers who do not use marijuana have genes that encode for the marijuana (cannabinoid) receptor proteins. 3. Primer pairs from CB1 and CB2 cDNA coding region sequences showed identical amplified DNA band sizes in both DNA-PCR and reverse PCR, with human templates. This suggests that the CB1 and CB2 genes are intronless at least in their coding regions. 4. An advantage of the coding region being intronless may be that the expression of these genes will have one major RNA processing event to skip, thus making the conditions of their expression relatively quick and simple. This advantage may have implications related to the biological functions of these proteins. 5. We therefore concluded that the existence of human cannabinoid receptors and genes along with the discovery of endogenous cannabinoids (endocannabinoids) may be useful markers in elucidating the role(s) and mechanism(s) of action of cannabinoids.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Onaivi ES,Chaudhuri G,Abaci AS,Parker M,Manier DH,Martin PR,Hubbard JR

doi

10.1016/s0278-5846(99)00052-4

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

1063-77

issue

6

eissn

0278-5846

issn

1878-4216

pii

S0278584699000524

journal_volume

23

pub_type

临床试验,杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in mild and moderate depression.

    abstract：BACKGROUND:Abnormal vasopressin (VP) and oxytocin (OT) signaling may contribute to the altered activity of the hypothalamo-pituitary-adrenal (HPA) axis in major depression; however, the underlying mechanisms remain uncertain. This study characterized plasma levels and affinities of OT- and VP-reactive autoantibodies (a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2010.09.021

    authors： Garcia FD,Coquerel Q,Kiive E,Déchelotte P,Harro J,Fetissov SO

    更新日期：2011-01-15 00:00:00

  • Is vitamin D hypothesis for schizophrenia valid? Independent segregation of psychosis in a family with vitamin-D-dependent rickets type IIA.

    abstract：:The vitamin D hypothesis of schizophrenia is a recent concept bringing together old observations on environmental risk factors and new findings on the neurodevelopmental effects of vitamin D. Candidate genes related to the vitamin D endocrine system have not yet been fully explored for this purpose. The coexistence of...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2003.10.002

    authors： Ozer S,Uluşahin A,Ulusoy S,Okur H,Coşkun T,Tuncali T,Göğüş A,Akarsu AN

    更新日期：2004-03-01 00:00:00

  • A review of pharmacological agents for self-injurious behavior.

    abstract：:1. The clinical literature regarding the effects of various psychotropic agents on self-injurious behavior is reviewed. Anecdotal reports, open trials and controlled studies are each reviewed. 2. The absence of controlled studies and the failure to distinguish self-injurious behaviors from other forms of aggression ar...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(90)90093-v

    authors： Luchins DJ

    更新日期：1990-01-01 00:00:00

  • Aging and visual hallucinations in elderly psychiatric outpatients.

    abstract：:Estimates of the reported prevalence of visual hallucinations in the elderly vary from study to study. The aim of the present investigation was to re-evaluate the prevalence of visual hallucinations in elderly psychiatric outpatients and to examine pertinent risk factors. One hundred and twenty-two elderly (> or =60 y...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2003.11.002

    authors： Soeda S,Terao T,Nishimura M,Nakamura J,Iwata N

    更新日期：2004-03-01 00:00:00

  • Aripiprazole augmentation in the management of residual symptoms in clozapine-treated outpatients with chronic schizophrenia: An open-label pilot study.

    abstract：OBJECTIVE:The aim of this study was to investigate whether augmentation of clozapine with aripiprazole improves clinically significant residual symptoms in stabilized outpatients with chronic schizophrenia. METHODS:Twenty seven stabilized outpatients meeting criteria for chronic schizophrenia, who had residual symptom...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2006.09.015

    authors： Mitsonis CI,Dimopoulos NP,Mitropoulos PA,Kararizou EG,Katsa AN,Tsakiris FE,Katsanou MN

    更新日期：2007-03-30 00:00:00

  • Comparison of prolactin concentrations between haloperidol and bromperidol treatments in schizophrenic patients.

    abstract：:The antipsychotic drug, bromperidol, is a close structural analogue of haloperidol. These two drugs also have similarities in metabolic pathways and pharmacological properties. In the present study, the prolactin concentrations in plasma during bromperidol versus haloperidol treatments were compared in the same indivi...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(01)00310-4

    authors： Yasui-Furukori N,Kondo T,Suzuki A,Mihara K,Kaneko S,Otani K

    更新日期：2002-04-01 00:00:00

  • New drug targets in the signaling pathways activated by antidepressants.

    abstract：:Studies of twins, genetic linkage and association support the existence of a genetic component to the susceptibility to depression. Biochemical parameters that change in depressive patients are also observed in their relatives. This indicates that genetic factors control these physiological changes and the susceptibil...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2005.03.017

    authors： Páez-Pereda M

    更新日期：2005-07-01 00:00:00

  • Stimulatory effect of desipramine on lung metastases of adenocarcinoma MADB 106 in stress highly-sensitive and stress non-reactive rats.

    abstract：:The effect of antidepressant drugs on tumor progress is very poorly recognized. The aim of the present study was to examine the effect of individual reactivity to stress and 24-day desipramine (DES) administration on the metastatic colonization of adenocarcinoma MADB 106 cells in the lungs of Wistar rats. Wistar rats ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.04.024

    authors： Grygier B,Kubera M,Wrona D,Roman A,Basta-Kaim A,Gruca P,Papp M,Rogoz Z,Leskiewicz M,Budziszewska B,Regulska M,Korzeniak B,Curzytek K,Glombik K,Slusarczyk J,Maes M,Lason W

    更新日期：2018-01-03 00:00:00

  • 5-HT1A receptor responsivity in anxiety disorders and depression.

    abstract：:1. Azapirones, selective partial agonists at the 5-HT1A receptor subtype, induce hypothermia and corticotropin (ACTH)/cortisol release as specific functional correlates of central 5-HT1A receptor activation. 2. Compared to controls, hypothermic and ACTH/cortisol responses to the azapirone ipsapirone are attenuated in ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(91)90001-h

    authors： Lesch KP

    更新日期：1991-01-01 00:00:00

  • Nicotine augmentation for refractory obsessive-compulsive disorder. A case report.

    abstract：:The authors present a case of obsessive-compulsive disorder (OCD) resistant to conventional treatments, which improved following nicotine augmentation administered as 4 mg chewing gum. The role of acetylcholine in the pathophysiology of OCD is not clear. The authors discuss the effect of nicotine on memory for actions...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.08.011

    authors： Pasquini M,Garavini A,Biondi M

    更新日期：2005-01-01 00:00:00

  • Adjunctive quetiapine in bipolar patients partially responsive to lithium or valproate.

    abstract：:Despite therapeutic treatment with lithium or valproate, patients with bipolar I disorder often require adjunctive therapy to treat persistent symptoms. In order to evaluate the effects of quetiapine for bipolar symptoms inadequately responsive to mood stabilizers, a retrospective chart review was undertaken at the Ve...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0278-5846(03)00145-3

    authors： Sokolski KN,Denson TF

    更新日期：2003-08-01 00:00:00

  • Phenomenology and neurobiology of cocaine withdrawal: are they related?

    abstract：:1. The presence of mood disturbances and platelet 3H-imipramine binding, a putative peripheral serotonergic marker, were evaluated in a group of 27 cocaine users three days after drug withdrawal. 2. Parameters of cocaine use and the linkage between cocaine withdrawal and "post-cocaine depression" were also investigate...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(95)00194-8

    authors： Pathiraja A,Marazziti D,Cassano GB,Diamond BI,Borison RL

    更新日期：1995-10-01 00:00:00

  • Differential effects of carbamazepine and lithium on sensitization and kindling.

    abstract：:Lithium carbonate appears to inhibit the development of cocaine-induced behavioral sensitization while it does not inhibit the development of amygdala kindling. Lithium chloride did not inhibit kindled seizures. Carbamazepine does not inhibit cocaine-induced motor activity or the development of behavioral sensitizatio...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Post RM,Weiss SR,Pert A

    更新日期：1984-01-01 00:00:00

  • Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases.

    abstract：:Neurodegenerative disorders are a subset of disabling pathologies characterized, in part, by a progressive and specific loss of certain brain cell populations. Current therapeutic approaches for the treatment of these disorders are mainly designed towards symptom management and do not manifestly block their typified n...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2010.11.023

    authors： Gibrat C,Cicchetti F

    更新日期：2011-03-30 00:00:00

  • Environmental enrichment improves cognitive deficits in Spontaneously Hypertensive Rats (SHR): relevance for Attention Deficit/Hyperactivity Disorder (ADHD).

    abstract：:The interaction between genes and environment seems to be relevant for the development of Attention Deficit/Hyperactivity Disorder (ADHD), one of the most prevalent childhood psychiatric diseases. The occurrence of ADHD is typically associated with poor academic performance, probably reflecting learning difficulties a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.06.012

    authors： Pamplona FA,Pandolfo P,Savoldi R,Prediger RD,Takahashi RN

    更新日期：2009-10-01 00:00:00

  • Clozapine regulation of p90RSK and c-Fos signaling via the ErbB1-ERK pathway is distinct from olanzapine and haloperidol in mouse cortex and striatum.

    abstract：:Treatment of the positive psychotic symptoms of schizophrenia with standard antipsychotic drugs (APDs) is ineffective in a proportion of cases. For these treatment resistant patients the alternative is the APD clozapine which is superior to other agents but carries serious side effects. Why clozapine is uniquely effec...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.10.025

    authors： Pereira A,Zhang B,Malcolm P,Sundram S

    更新日期：2013-01-10 00:00:00

  • Monitoring of haloperidol serum levels and it's clinical significance.

    abstract：:Haloperidol serum levels were determined by the recently developed radioimmunoassay technique to elucidate the relationship between serum levels and clinical effects and that between serum levels and adverse effects. The serum levels of haloperidol in divided daily doses schedule reached to the steady state more rapid...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(84)90135-0

    authors： Itoh H,Yagi G,Tateyama M,Fujii Y,Iwamura K,Ichikawa K

    更新日期：1984-01-01 00:00:00

  • Slow magnetic stimulation of prefrontal cortex in depression and schizophrenia.

    abstract：:1. The authors used transcranial magnetic stimulation (TMS) of pre-frontal cortex to study mood changes in 10 depressed patients and 10 schizophrenic patients. 2. A slow rate of stimuli was used, one per 30 seconds; maximal intensity of about 2 Tesla was given for 30 stimuli, 15 on each side of the brain. 3. No side e...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(96)00161-3

    authors： Geller V,Grisaru N,Abarbanel JM,Lemberg T,Belmaker RH

    更新日期：1997-01-01 00:00:00

  • Metabolism of antidepressants: urinary metabolites of trimipramine in the rat.

    abstract：:1. Studies on the metabolism of the tricyclic antidepressant trimipramine (TMP) in the rat are described. 2. Twenty metabolites of TMP were isolated from rat urine after enzymatic hydrolysis and their structures were determined by a gas chromatographic-mass spectrometric (GC-MS) method. 3. Twelve TMP metabolites were ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(91)90094-h

    authors： Hussain MS,Coutts RT,Baker GB,Micetich RG,Daneshtalab M

    更新日期：1991-01-01 00:00:00

  • Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: a meta-analysis.

    abstract：:Hypericum perforatum is a medicinal plant with established antidepressant properties. The aim of this meta-analysis was to compare the efficacy and tolerability of this antidepressant with selective serotonin reuptake inhibitors (SSRIs) as a group of standard antidepressants. For this purpose, Pubmed, Embase, Scopus, ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.pnpbp.2008.10.018

    authors： Rahimi R,Nikfar S,Abdollahi M

    更新日期：2009-02-01 00:00:00

  • Early life social experience affects adulthood fear extinction deficit and associated dopamine profile abnormalities in a rat model of PTSD.

    abstract：:Individuals may develop fear extinction deficits after life-threatening traumatic events; such deficits indicate posttraumatic stress disorder (PTSD). Because the occurrence of this disorder differs among people who have experienced trauma, hidden underlying factors should be determined. Increasing evidence suggests t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2020.109914

    authors： Lin CC,Chen TY,Cheng PY,Liu YP

    更新日期：2020-07-13 00:00:00

  • Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer.

    abstract：:Codeine is metabolized by the cytochrome P450 2D6 (CYP2D6) to morphine. Codeine is a much weaker agonist at mu opioid receptors than morphine. Therefore, codeine analgesia is highly dependent on CYP2D6 activity. Large prospective studies in the clinical environment do not exist, but it appears reasonable to avoid code...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.03.018

    authors： Susce MT,Murray-Carmichael E,de Leon J

    更新日期：2006-09-30 00:00:00

  • Long-term impact of chronic variable stress in adolescence versus adulthood.

    abstract：:Adolescence is a period of active development of stress regulatory neurocircuitry. As a consequence, mechanisms that control the responses to stress are not fully matured during this developmental period, which may result in vulnerability to chronic stress. We hypothesized that adolescent chronic stress would have neg...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.08.003

    authors： Cotella EM,Gómez AS,Lemen P,Chen C,Fernández G,Hansen C,Herman JP,Paglini MG

    更新日期：2019-01-10 00:00:00

  • Litter has an effect on the behavioural changes caused by the administration of the nitric oxide synthase inhibitor NG-nitro-L-arginine and ethanol in mice.

    abstract：:The aim of the work was to study the effects of litter and the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) on the behaviour of mice after acute and chronic ethanol administration and withdrawal. Male outbred NIH/S mice, from 21 litters, were distributed among experimental groups and subjected t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.06.008

    authors： Okva K,Lang A,Pokk P,Väli M,Nevalainen T

    更新日期：2004-11-01 00:00:00

  • Scopolamine-physostigmine combination does not substitute for nicotine.

    abstract：:1. Male Sprague-Dawley rats were trained to discriminate 0.4 mg/kg nicotine subcutaneously administered from its saline vehicle in a food-motivated operant discrimination task. Once trained, the discriminative performance was observed to be dose-responsive with an ED50 = 0.11 mg/kg. 2. The co-administration of 0.1 or ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(95)00030-y

    authors： Schechter MD

    更新日期：1995-05-01 00:00:00

  • Cerebral HMPAO SPECT in patients with major depression and healthy volunteers.

    abstract：:1. The authors examined the regional cerebral distribution of [Tc-99m] HMPAO using single photon emission computed tomography (SPECT) in patients with major depression and in healthy controls. 2. 19 patients and 16 healthy controls had SPECT images of the brain acquired with 740 MBq (20 mCl) of [Tc-99m] HMPAO on a tri...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(96)00008-5

    authors： Mozley PD,Hornig-Rohan M,Woda AM,Kim HJ,Alavi A,Payer F,Amsterdam JD

    更新日期：1996-04-01 00:00:00

  • Chronic stimulation of the cat vagus nerve: effect on sleep and behavior.

    abstract：:The effect of electrical vagus nerve stimulation (VNS) on sleep and behavior was analyzed in freely moving cats. Eight cats were prepared for 23-h sleep recordings. The left vagus nerve of four of them was stimulated during 1 min, five times at 1-h intervals, for 5 days. The VNS induces: ipsilateral myosis, blinking, ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(01)00228-7

    authors： Valdés-Cruz A,Magdaleno-Madrigal VM,Martínez-Vargas D,Fernández-Mas R,Almazán-Alvarado S,Martínez A,Fernández-Guardiola A

    更新日期：2002-01-01 00:00:00

  • Infertility treatments during pregnancy and the risk of autism spectrum disorder in the offspring.

    abstract：:We aimed to examine the effects of infertility treatments on the risk of Autism Spectrum Disorder (ASD). Data were from a representative national registry on 110,093 male live births in Israel (born: 1999-2008; and ASD: 975, 0.9%). Infertility treatments included In Vitro Fertilization (IVF), and five hormone treatmen...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.05.022

    authors： Davidovitch M,Chodick G,Shalev V,Eisenberg VH,Dan U,Reichenberg A,Sandin S,Levine SZ

    更新日期：2018-08-30 00:00:00

  • Motor-induced brain activation in cortical, subcortical and cerebellar regions in schizophrenic inpatients. A whole brain fMRI fingertapping study.

    abstract：:Motor symptoms including neurological soft signs have been found to be more prevalent in schizophrenic patients. In addition, catatonic symptoms and neuroleptic treatment as well may influence cortical and subcortical motor organization in schizophrenia. The results of previous neuroimaging studies exploring motor fun...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(01)00271-8

    authors： Müller JL,Röder CH,Schuierer G,Klein H

    更新日期：2002-04-01 00:00:00

  • Interferon: a candidate as the endogenous substance preventing tolerance and dependence to brain opioids.

    abstract：:It has been suggested that protein synthesis and immunological factors play a role in the development of tolerance and dependence to opiates. Interferon (IFN) is known to influence protein synthesis and the immune system. Our and other data suggest that IFN may be an agent that prevents the development of tolerance an...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Dafny N

    更新日期：1984-01-01 00:00:00