Differential effects of carbamazepine and lithium on sensitization and kindling.

abstract：:Although ECT is a highly effective treatment for severe depression and other psychiatric syndromes, its mode of action is not known. Recent studies have suggested that effects of ECT on central neurotransmitter receptors may underlie its therapeutic action. The effects of chronically administered electroconvulsive sho...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lerer B,Sitaram N

更新日期：1983-01-01 00:00:00

abstract：:Neuroinflammatory changes have been demonstrated to be an important feature of Alzheimer's disease (AD); however, the exact role of neuroinflammation and its progression during disease is still not well understood. One of the main drivers of the neuroinflammatory process are microglial cells. Positron Emission Tomogra...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Knezevic D,Mizrahi R

更新日期：2018-01-03 00:00:00

abstract：:Alzheimer's disease (AD) by progressive neurodegenerative pattern is associated with autophagy stress which is suggested as a potential cause of amyloid β (Aβ) aggregation and neural loss. Apelin-13, a neuropeptide with modulatory effect on autophagy, has been shown the beneficial effects on neural cell injuries. We i...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Aminyavari S,Zahmatkesh M,Farahmandfar M,Khodagholi F,Dargahi L,Zarrindast MR

更新日期：2019-03-08 00:00:00

abstract：:Xiaobuxin-Tang (XBXT), a traditional Chinese herbal decoction, has been used for the treatment of depressive disorders for centuries in China. Our previous studies have demonstrated that the total flavonoids (XBXT-2) isolated from the extract of XBXT reversed behavioral alterations and serotonergic dysfunctions in chr...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： An L,Zhang YZ,Yu NJ,Liu XM,Zhao N,Yuan L,Chen HX,Li YF

更新日期：2008-08-01 00:00:00

abstract：:Sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, has recently been reported to affect convulsant activity in some animal models of seizures and epilepsy. Moreover, its influence on the protective activity of some antiepileptic drugs (AEDs) was also noted. The aim of the present study was to investigate th...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Nieoczym D,Socała K,Luszczki JJ,Czuczwar SJ,Wlaź P

更新日期：2012-10-01 00:00:00

abstract：:Degeneration of cholinergic cortical neurons is one of the main reasons for the cognitive deficit in dementia of the Alzheimer type (AD) and in dementia with Lewy bodies (DLB). Many subjects with AD and DLB have extrapyramidal dysfunction and depression resulting from degeneration of dopaminergic, noradrenergic and se...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Weinstock M,Gorodetsky E,Poltyrev T,Gross A,Sagi Y,Youdim M

更新日期：2003-06-01 00:00:00

abstract：:1. Agonists may act at any one of three sites on the N-methyl-D-aspartate (NMDA) receptor-effector complex to promote opening of the associated ion channel. The three sites are activated by i) NMDA, L-glutamate, aspartate, and other dicarboxylic amino acids; ii) glycine, D-serine, D-cycloserine, and others; iii) the p...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lehmann J,Colpaert F,Canton H

更新日期：1991-01-01 00:00:00

abstract：:Several studies have shown that the α₁-adrenoreceptor is involved in controlling extracellular serotonin levels. The administration of the α₁-adrenoreceptor antagonist prazosin was shown to decrease extracellular serotonin levels in the hippocampus, the prefrontal cortex and the raphe nucleus, while the administration...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Takamura N,Masuda T,Inoue T,Nakagawa S,Koyama T

更新日期：2012-10-01 00:00:00

abstract：:To date, no study has examined the pituitary volumes in patients with hypochondriasis. In the present study, we evaluated pituitary volumes in patients with hypochondriasis and healthy controls. Twenty individuals with hypochondriasis (ten males, ten females), aged 20 to 48 years, and healthy controls were included in...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Atmaca M,Yildirim H,Sec S,Kayali A

更新日期：2010-03-17 00:00:00

abstract：:The identification of key genes in transcriptomic data constitutes a huge challenge. Our review of microarray reports revealed 88 genes whose transcription is consistently regulated by glucocorticoids (GCs), such as cortisol, corticosterone and dexamethasone, in the brain. Replicable transcriptomic data were combined ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Juszczak GR,Stankiewicz AM

更新日期：2018-03-02 00:00:00

abstract：:Recent evidence indicates that the vascular endothelial growth factor (VEGF) may be involved in the neuronal mechanisms underlying both the depression aetiology and the response to pharmacological and non pharmacological antidepressant treatments. To investigate whether VEGF peripheral levels are altered in depression...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ventriglia M,Zanardini R,Pedrini L,Placentino A,Nielsen MG,Gennarelli M,Bocchio-Chiavetto L

更新日期：2009-02-01 00:00:00

abstract：:Accumulating evidence supports the hypothesis that modulation of glutamatergic system via NMDA receptors and mGlu5 receptors might be an effective antidepressant therapy. However, clinical application of NMDA and mGlu5 antagonists in the therapy of depression is still an open question. In the present study we investig...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pałucha-Poniewiera A,Pilc A

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:The use of clozapine or other second generation antipsychotics (SGAs) has been reported to produce obsessive compulsive (OC) symptoms as adverse mental affects. However, it is not yet clear if SGA-induced OC symptoms have the same phenomenological characteristics as those displayed in obsessive compulsive dis...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kim JH,Ryu S,Nam HJ,Lim M,Baek JH,Joo YH,Kwon JS,Ha TH,Hong KS

更新日期：2012-10-01 00:00:00

abstract：:Dietary antioxidants might exert an important role in the aging process by relieving oxidative damage, a likely cause of age-associated brain dysfunctions. This study aims to investigate the influence of esculetin (6,7-dihydroxycoumarin), a naturally occurring antioxidant in the diet, on mood-related behaviors and cog...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Martín-Aragón S,Villar Á,Benedí J

更新日期：2016-02-04 00:00:00

abstract：OBJECTIVE:Previous studies have indicated that the immune may be involved in the pathogenesis of tardive dyskinesia (TD). Some genetic polymorphisms in the human leukocyte antigen (HLA) I and II regions have been associated with TD, and the tumor necrosis factor-α (TNF-α) gene is located in the HLA III region. TNF-α le...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wang F,Fan H,Sun H,Yang F,Luo Y,Liu H,Kosten TR,Lu L,Zhang XY

更新日期：2012-04-27 00:00:00

abstract：:Mecamylamine, a noncompetitive antagonist of nicotinic acetylcholine receptors, has many potential clinical applications, including treating alcohol dependency. However, little is known about the combined effects of mecamylamine and alcohol on visual system electrophysiology. We examined the separate and combined effe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hetzler BE,Bauer AM

更新日期：2013-06-03 00:00:00

abstract：:Supratherapeutic doses of the analgesic acetaminophen (paracetomol) are reported to promote social behavior in Swiss mice. However, we hypothesized that it might not promote sociability in other strains due to cannabinoid CB(1) receptor-mediated inhibition of serotonin (5-HT) transmission in the frontal cortex. We exa...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gould GG,Seillier A,Weiss G,Giuffrida A,Burke TF,Hensler JG,Rock C,Tristan A,McMahon LR,Salazar A,O'Connor JC,Satsangi N,Satsangi RK,Gu TT,Treat K,Smolik C,Schultz ST

更新日期：2012-08-07 00:00:00

abstract：:The aim of the present study was to evaluate the putative antidepressive and cognitive enhancer effects of phosphatidylserine (BC-PS). The antidepressive effect of BC-PS (50, 100 or 200 mg/kg), compared to saline or imipramine (IMI; 25 mg/kg), was studied in the forced swimming test in rats. These drugs were administe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Castilho JC,Perry JC,Andreatini R,Vital MA

更新日期：2004-07-01 00:00:00

abstract：:Group II metabotropic glutamate receptor (mGluR2/3) agonists once showed promise as non-dopaminergic antipsychotic drugs because of their efficacy in alleviating symptoms of schizophrenia (SZ) in both animal models and human patients. However, the recent failure of Phase III clinical trials dealt a huge blow to the sc...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Li ML,Hu XQ,Li F,Gao WJ

更新日期：2015-07-03 00:00:00

abstract：:1. A statistically significant increased risk of schizophrenia for individuals born in winter has been reported. The increase risk is of the order of 5-15 percent. The seasonal effect is more marked among females. This winter birth effect suggests some environmental agents, probably a neuropathogen one, acting on the ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dassa D,Azorin JM,Ledoray V,Sambuc R,Giudicelli S

更新日期：1996-02-01 00:00:00

abstract：:Cocaine dependence is a complex psychiatric disorder that is highly comorbid with other psychiatric traits. Twin and adoption studies suggest that genetic variants contribute substantially to cocaine dependence susceptibility, which has an estimated heritability of 65-79%. Here we performed a meta-analysis of genome-w...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Cabana-Domínguez J,Shivalikanjli A,Fernàndez-Castillo N,Cormand B

更新日期：2019-08-30 00:00:00

abstract：BACKGROUND:Chronic substance abuse has been associated with decrements in the processing and expression of language. The present study utilized the N400 event-related electroencephalographic potential to index semantic processing in 133 adults with (n=49) or without (n=84) a history of alcohol and/or cocaine dependence...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ceballos NA,Houston RJ,Smith ND,Bauer LO,Taylor RE

更新日期：2005-07-01 00:00:00

abstract：:1. Preclinical studies reveal that long-term treatment with antidepressant drugs induces significant changes in serotonergic (5-HT) receptor sensitivity. Similarly, clinical studies suggest that brain 5-HT function is abnormal in depression. Of the available methodologies for conducting such clinical studies, the phar...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Price LH,Charney DS,Delgado PL,Goodman WK,Krystal JH,Woods SW,Heninger GR

更新日期：1990-01-01 00:00:00

abstract：:Ibogaine (IBO) is an alkaloid with putative antiaddictive properties, alleviating opiates dependence and withdrawal. The glutamate N-methyl-D-aspartate (NMDA) receptors have been implicated in the physiological basis of drug addiction; accordingly, IBO acts as a noncompetitive NMDA antagonist. The purpose of this stud...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Leal MB,Michelin K,Souza DO,Elisabetsky E

更新日期：2003-08-01 00:00:00

abstract：:Gender differences in various clinical features of schizophrenia have been noted and estrogen has been regarded to play important roles. A few previous studies on the association between estrogen receptor (ER) genotypes and schizophrenia focused mainly on ER α gene but failed to report consistent results. The present ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Min JA,Kim JJ,Pae CU,Kim KH,Lee CU,Lee C,Paik IH

更新日期：2012-01-10 00:00:00

abstract：:The present study investigated the effect of monoamine oxidase inhibitors, nialamide which is a non specific monoamine oxidase inhibitor (MAOI), toloxatone which is a A type MAOI and L-deprenyl which is a B type MAOI compared with classical tricyclic antidepressants (clomipramine, desipramine and imipramine), on the e...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Martin P,Soubrie P,Simon P

更新日期：1987-01-01 00:00:00

abstract：:The complexity of the human brain emerges from a long and finely tuned developmental process orchestrated by the crosstalk between genome and environment. Vis à vis other species, the human brain displays unique functional and morphological features that result from this extensive developmental process that is, unsurp...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gabriele M,Lopez Tobon A,D'Agostino G,Testa G

更新日期：2018-06-08 00:00:00

abstract：:In the present study, we tested the hypothesis that the potent and selective dopamine-β-hydroxylase (DβH) inhibitor nepicastat would have minimal effects on cardiovascular and pharmacokinetic parameters associated with cocaine administration and would reduce the positive subjective effects produced by cocaine. We cond...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： De La Garza R 2nd,Bubar MJ,Carbone CL,Moeller FG,Newton TF,Anastasio NC,Harper TA,Ware DL,Fuller MA,Holstein GJ,Jayroe JB,Bandak SI,Reiman KZ,Neale AC,Pickford LB,Cunningham KA

更新日期：2015-06-03 00:00:00

abstract：:The selective serotonin reuptake inhibitors (SSRIs) have emerged as a major therapeutic advance in psychopharmacology. As a result, the discovery of these agents marks a milestone in neuropsychopharmacology and rational drug design, and has launched a new era in psychotropic drug development. Prior to the SSRIs, all p...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Vaswani M,Linda FK,Ramesh S

更新日期：2003-02-01 00:00:00

abstract：:The growing popularity of zebrafish in psychopharmacology and behavioral brain research is partly due to the practicality and simplicity of drug administration in this species. Several drugs may be administered to zebrafish by immersing the fish in the drug solution. Furthermore, numerous drugs developed for mammals, ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zahid H,Tsang B,Ahmed H,Lee RCY,Tran S,Gerlai R

更新日期：2018-04-20 00:00:00