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Phosphatidylserine: an antidepressive or a cognitive enhancer?

Abstract：

:The aim of the present study was to evaluate the putative antidepressive and cognitive enhancer effects of phosphatidylserine (BC-PS). The antidepressive effect of BC-PS (50, 100 or 200 mg/kg), compared to saline or imipramine (IMI; 25 mg/kg), was studied in the forced swimming test in rats. These drugs were administered 1 and 8 h after training and 1 h before the test. BC-PS (50, 100 and 200 mg/kg)-treated rats exhibited a significant decrease in immobility time (IT) in the test session (performed 24 h after training) when compared to control rats. Moreover, the IMI-treated group showed a significant reduction in IT in comparison to control rats. The cognitive enhancer effect of BC-PS (50, 100 and 200 mg/kg) was studied in the three versions of the water maze task: spatial working memory version, spatial reference memory version, and cued version. There was no significant difference between the BC-PS-treated groups and control animals in these memory tasks. Taken together, the present results are suggestive of an antidepressive effect of BC-PS in the forced swimming test in rats but not of a cognitive enhancer effect of the drug in the water maze test.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Castilho JC,Perry JC,Andreatini R,Vital MA

doi

10.1016/j.pnpbp.2004.05.013

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

731-8

issue

4

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(04)00071-5

journal_volume

28

pub_type

杂志文章

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