当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia.

Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia.

Abstract：

:Neuropsychological endophenotype approach is an emerging strategy in schizophrenia research to understand and identify the functional importance of genetically transmitted, brain-based deficits present in this disorder. Accumulating evidence indicated that working memory deficit is a core neuropsychological dysfunction in schizophrenia and a primary endophenotype indexing the liability to develop schizophrenia. Genetic variation in ankyrin 3 gene (ANK3) is likely to have widespread cognitive effects. Our previous study has identified a significant association of ANK3 SNPs and schizophrenia. In this study, we aimed to examine whether the schizophrenia-risk SNPs within ANK3 may affect working memory deficits in schizophrenia patients. Herein, we assess the working memory performance in 163 patients with first-episode, antipsychotic-naïve schizophrenia and 42 sex, age-matched healthy subjects using N-back task. Two SNPs rs10761482 and rs10994336 were genotyped among the patients and 209 controls. Our results showed that schizophrenia patients showed significantly poorer performance than healthy controls on N-back task (ps<0.01). After adjusting for the scores of intelligence quotient, memory quotient and the demographic factors, there was a significant genotype effect of the rs10994336 on the accuracy rate and reaction time of 2-back item (p=0.048 and 0.024, respectively). Post-hoc analyses showed that patients with rs10994336T/T genotype had significantly lower accuracy rate and more reaction time at 2-back task than those with T/C and C/C genotypes. The association of SNP rs10994336 with schizophrenia was replicated in our sample (genotypic p=0.024 and allelic p=0.006). However, we did not find any significant association of rs10761482 with schizophrenia and parameters in N-back task. Our results indicated that genetic variation within ANK3 may exert gene-specific modulating effects on working memory deficits in schizophrenia.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Zhang C,Cai J,Zhang J,Li Z,Guo Z,Zhang X,Lu W,Zhang Y,Yuan A,Yu S,Fang Y

doi

10.1016/j.pnpbp.2013.12.010

subject

Has Abstract

pub_date

2014-04-03 00:00:00

pages

110-5

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(13)00289-3

journal_volume

50

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial.

    abstract：:Depression is one of the most common neuropsychiatric conditions, with a lifetime prevalence approaching 17%. Although a variety of pharmaceutical agents is available for the treatment of depression, psychiatrists find that many patients cannot tolerate the side effects, do not respond adequately, or finally lose thei...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2006.11.010

    authors： Akhondzadeh Basti A,Moshiri E,Noorbala AA,Jamshidi AH,Abbasi SH,Akhondzadeh S

    更新日期：2007-03-30 00:00:00

  • Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment.

    abstract：:Neuroinflammatory changes have been demonstrated to be an important feature of Alzheimer's disease (AD); however, the exact role of neuroinflammation and its progression during disease is still not well understood. One of the main drivers of the neuroinflammatory process are microglial cells. Positron Emission Tomogra...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2017.05.007

    authors： Knezevic D,Mizrahi R

    更新日期：2018-01-03 00:00:00

  • Interferon: a candidate as the endogenous substance preventing tolerance and dependence to brain opioids.

    abstract：:It has been suggested that protein synthesis and immunological factors play a role in the development of tolerance and dependence to opiates. Interferon (IFN) is known to influence protein synthesis and the immune system. Our and other data suggest that IFN may be an agent that prevents the development of tolerance an...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Dafny N

    更新日期：1984-01-01 00:00:00

  • beta-adrenergic enhancement of brain kynurenic acid production mediated via cAMP-related protein kinase A signaling.

    abstract：:The central levels of endogenous tryptophan metabolite kynurenic acid (KYNA), an antagonist of N-methyl-d-aspartate (NMDA) and alpha7-nicotinic receptors, affect glutamatergic and dopaminergic neurotransmission. Here, we demonstrate that selective agonists of beta(1)-receptors (xamoterol and denopamine), beta(2)-recep...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.02.002

    authors： Luchowska E,Kloc R,Olajossy B,Wnuk S,Wielosz M,Owe-Larsson B,Urbanska EM

    更新日期：2009-04-30 00:00:00

  • Replication of previous GWAS hits suggests the association between rs4307059 near MSNP1AS and autism in a Chinese Han population.

    abstract：:Autism is a complex neurodevelopmental disorder with high heritability. Previous genome-wide association studies (GWAS) demonstrated that some single-nucleotide polymorphisms (SNPs) were significantly associated with autism, while other studies focusing on these GWAS hits showed inconsistent results. Besides, the asso...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.12.016

    authors： Wang Z,Zhang J,Lu T,Zhang T,Jia M,Ruan Y,Zhang D,Li J,Wang L

    更新日期：2019-06-08 00:00:00

  • Delusional infestation: neural correlates and antipsychotic therapy investigated by multimodal neuroimaging.

    abstract：INTRODUCTION:In delusional infestation (DI), as with other non-schizophrenic psychotic disorders, little is known about the neural basis and the mechanisms of antipsychotic treatment. We aimed at investigating the brain circuitry involved in DI and the role of postsynaptic D2 receptors in mediating the effects of antip...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2010.06.022

    authors： Freudenmann RW,Kölle M,Huwe A,Luster M,Reske SN,Huber M,Lepping P,Wolf RC,Schönfeldt-Lecuona C

    更新日期：2010-10-01 00:00:00

  • State-independent alterations of intrinsic brain network in current and remitted depression.

    abstract：BACKGROUND:It has been proposed that state-independent, or trait, neurobiological alterations across illness phases may contribute to the high recurrence of major depressive disorder (MDD). Although intrinsic brain network abnormalities have been implicated consistently in MDD neuropathology, MDD state-independent and ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.08.031

    authors： Dong D,Ming Q,Zhong X,Pu W,Zhang X,Jiang Y,Gao Y,Sun X,Wang X,Yao S

    更新日期：2019-03-08 00:00:00

  • Insulin resistance and metabolic profile in antipsychotic naïve schizophrenia patients.

    abstract：OBJECTIVES:Several studies have suggested insulin resistance related to dyslipidemia and body weight in drug treated schizophrenia patients. Although, insulin resistance or impaired glucose tolerance is also reported in antipsychotic naïve schizophrenia patients, their relationship with dyslipidemic changes and body we...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2010.06.011

    authors： Dasgupta A,Singh OP,Rout JK,Saha T,Mandal S

    更新日期：2010-10-01 00:00:00

  • Schizophrenia and single-carbon metabolism.

    abstract：:Schizophrenic patients generally appear to have a disturbed single-carbon metabolism. Methionine and homocysteine are intermediary metabolites in this metabolic system. In a case-control study of the cerebrospinal fluid, a majority of the patients had elevated methionine and a smaller subgroup had elevated homocystein...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2005.06.023

    authors： Regland B

    更新日期：2005-09-01 00:00:00

  • Effects of rimonabant on the development of single dose-induced behavioral sensitization to ethanol, morphine and cocaine in mice.

    abstract：RATIONALE:The endocannabinoid system has been implicated in the neurobiological mechanism underlying drug addiction, especially the primary rewarding dopamine-dependent processes. Therefore, endocannabinoid receptor antagonists, such as the CB1 cannabinoid antagonist rimonabant, have been proposed as candidates for pre...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2014.11.010

    authors： Marinho EA,Oliveira-Lima AJ,Santos R,Hollais AW,Baldaia MA,Wuo-Silva R,Yokoyama TS,Takatsu-Coleman AL,Patti CL,Longo BM,Berro LF,Frussa-Filho R

    更新日期：2015-04-03 00:00:00

  • The effects of chronic ethanol consumption and withdrawal on passive avoidance task and serum cholinesterase level in rats.

    abstract：:The effects of chronic ethanol consumption and ethanol withdrawal on serum cholinesterase (ChE) activity and passive avoidance task in rats were investigated. Ethanol was administered to rats by a modified liquid diet with 4.8% (v/v) ethanol for 3 days followed by 25 days on a liquid diet in which the ethanol concentr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.11.012

    authors： Celik T,Cakir E,Kayir H,Bilgi C,Uzbay IT

    更新日期：2005-05-01 00:00:00

  • Relationship between 3H-imipramine binding, 14C-serotonin uptake, and the surface area of blood platelets.

    abstract：:1. The relationship between 14C-serotonin uptake, 3H-imipramine binding and surface area was studied in blood platelets. 2. Platelet rich plasma from 5 normal subjects was divided into 5 size subfractions by differential centrifugation and the total surface areas computed from platelet size profiles. 3. Linear relatio...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(90)90017-b

    authors： Demet EM,Chicz-Demet A,Shaffer E,Ocariz J

    更新日期：1990-01-01 00:00:00

  • Cross-species behavioural genetics: A starting point for unravelling the neurobiology of human psychiatric disorders.

    abstract：:Identifying the genetic and neurobiological mechanisms underlying certain behavioural traits is an important strategy to understand the aetiology of various psychiatric disorders and to find potential new treatment possibilities. It has proven a great challenge to develop paradigms that allow translational research fo...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2010.10.003

    authors： de Mooij-van Malsen AJ,Vinkers CH,Peterse DP,Olivier B,Kas MJ

    更新日期：2011-08-01 00:00:00

  • SSRIs and conditioned fear.

    abstract：:Among drugs that act on serotonergic neurotransmission, selective serotonin (5-HT) reuptake inhibitors (SSRIs) are now the gold standard for the treatment of anxiety disorders. The precise mechanisms of the anxiolytic actions of SSRIs are unclear. We reviewed the literature related to the effects of SSRIs and the neur...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2011.09.002

    authors： Inoue T,Kitaichi Y,Koyama T

    更新日期：2011-12-01 00:00:00

  • Moclobemide, an inhibitor of MAO-A, does not increase daytime plasma melatonin levels in normal humans.

    abstract：:1. Plasma melatonin concentrations were determined after administration of single oral doses (100, 200 and 300 mg) of moclobemide, a reversible inhibitor of monoamine oxidase (MAO) with predominant effects on the A-type of the enzyme, to eight young, healthy male volunteers in a double-blind, random-order, placebo-con...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0278-5846(90)90065-o

    authors： Scheinin M,Koulu M,Vakkuri O,Vuorinen J,Zimmer RH

    更新日期：1990-01-01 00:00:00

  • Changes in EEG, blood levels, mood scales and performance scores during long term treatment with diazepam, phenobarbital or placebo in patients.

    abstract：:1. The patient population consisting of fifteen patients was divided into three groups, namely: diazepam group, phenobarbital group and placebo group. After three weeks the medicated groups were switched to placebo for a week and the placebo group was given phenobarbital. 2. The parameters to be assessed once a week c...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0278-5846(82)80175-9

    authors： Schwarz E,Kielholz P,Hobi V,Goldberg L,Hofstetter M,Ladewig D

    更新日期：1982-01-01 00:00:00

  • Noradrenergic facilitation of shock-probe defensive burying in lateral septum of rats, and modulation by chronic treatment with desipramine.

    abstract：:We have previously shown that acute stress-induced release of norepinephrine (NE) facilitates anxiety-like behavioral responses to stress, such as reduction in open-arm exploration on the elevated-plus maze and in social behavior on the social interaction test. Since these responses represent inhibition of ongoing beh...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.11.015

    authors： Bondi CO,Barrera G,Lapiz MD,Bedard T,Mahan A,Morilak DA

    更新日期：2007-03-30 00:00:00

  • In vitro effects of melatonin on [3H]muscimol binding in rat brain.

    abstract：:The possible interaction of melatonin with the GABAergic system at the receptor level was investigated. The effect of melatonin on the binding of the GABA agonist, [3H]muscimol, in crude synaptic membrane preparations was assayed. In fresh membrane preparations, melatonin increased [3H]muscimol binding in the rat stri...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(84)90034-4

    authors： Coloma FM,Niles LP

    更新日期：1984-01-01 00:00:00

  • Association between MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies.

    abstract：BACKGROUND:Previous studies concerning the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and depression have provided inconclusive findings. A meta-analysis was therefore performed to investigate a more reliable estimate. METHODS:This meta-analysis recruited 26 publis...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.pnpbp.2013.06.015

    authors： Wu YL,Ding XX,Sun YH,Yang HY,Chen J,Zhao X,Jiang YH,Lv XL,Wu ZQ

    更新日期：2013-10-01 00:00:00

  • Neuropathological relationship between major depression and dementia: A hypothetical model and review.

    abstract：:Major depression (MDD) is a chronic psychiatric condition in which patients often show increasing cognitive impairment with recurring episodes. Neurodegeneration may play an important component in the pathogenesis of MDD associated with cognitive complaints. In agreement with this, patients with MDD show decreased bra...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2016.01.008

    authors： Kim HK,Nunes PV,Oliveira KC,Young LT,Lafer B

    更新日期：2016-06-03 00:00:00

  • Perospirone in treatment of Huntington's disease: a first case report.

    abstract：:Huntington's disease (HD) is a hereditary disorder clinically characterized by involuntary movements, cognitive decline and psychiatric symptoms. We report on a patient with HD, whose involuntary movements and psychiatric symptoms were clinically improved with perospirone, a second-generation antipsychotic agent with ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.06.021

    authors： Roppongi T,Togo T,Nakamura S,Asami T,Yoshimi A,Shiozaki K,Kato D,Kawanishi C,Hirayasu Y

    更新日期：2007-01-30 00:00:00

  • Strain-dependent modification of behavior following antidepressant treatment.

    abstract：:The effects of repeated antidepressant drug treatment on behavioral outcome in Wistar Kyoto (WKY) rats, a putative animal model of depressive behavior, were compared to Wistar and Sprague-Dawley (SD) rats. Rats were treated with desipramine (norepinephrine [NE] uptake blocker), nomifensine (NE and dopamine [DA] uptake...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(02)00308-1

    authors： Tejani-Butt S,Kluczynski J,Paré WP

    更新日期：2003-02-01 00:00:00

  • The contributions of the endocannabinoid system and stress on the neural processing of reward stimuli.

    abstract：:The brain's endocannabinoid system plays a crucial role in reward processes by mediating appetitive learning and encoding the reinforcing properties of substances. Evidence also suggests that endocannabinoids are an important constituent of neuronal substrates involved in emotional responses to stress. Thus, it is cri...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2020.110183

    authors： Filbey FM,Beaton D,Prashad S

    更新日期：2021-03-02 00:00:00

  • Pleiotropic genes in psychiatry: Calcium channels and the stress-related FKBP5 gene in antidepressant resistance.

    abstract：:A candidate gene and a genome-wide approach were combined to study the pharmacogenetics of antidepressant response and resistance. Investigated genes were selected on the basis of pleiotropic effect across psychiatric phenotypes in previous genome-wide association studies and involvement in antidepressant response. Th...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.pnpbp.2017.10.005

    authors： Fabbri C,Corponi F,Albani D,Raimondi I,Forloni G,Schruers K,Kasper S,Kautzky A,Zohar J,Souery D,Montgomery S,Cristalli CP,Mantovani V,Mendlewicz J,Serretti A

    更新日期：2018-02-02 00:00:00

  • Metabolic treatment of hyperuricosuric autism.

    abstract：:A single male subject with hyperuricosuric autism was treated for a period of 2 years with an oral dose of uridine, which increased from 50 to 500 mg/kg/day. This patient experienced dramatic social, cognitive, language, and motor improvements. These improvement decreased within 72 h of the discontinuation of uridine,...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(01)00249-4

    authors： Page T,Moseley C

    更新日期：2002-02-01 00:00:00

  • Elevated plasma γ-aminobutyrate/glutamate ratio and responses to risperidone antipsychotic treatment in schizophrenia.

    abstract：BACKGROUND:γ-aminobutyrate (GABA) and Glutamate (Glu) are respectively two major inhibitory and excitatory neurotransmitters in the central nervous system and recent theories propose that both of their signaling complexes are compromised in patients with schizophrenia. METHODS:The changes in plasma GABA, Glu and GABA/...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2010.07.006

    authors： Cai HL,Zhu RH,Li HD,Zhang XH,Hu L,Yang W,Ye HS

    更新日期：2010-10-01 00:00:00

  • Molecular aspects of monoamine oxidase B.

    abstract：:Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets. MAO B structure, function and kinetics are described as a background for the effect of alterations in its activity on behavior. The need...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2016.02.005

    authors： Ramsay RR

    更新日期：2016-08-01 00:00:00

  • Disrupted regional homogeneity in treatment-resistant depression: a resting-state fMRI study.

    abstract：BACKGROUND:Using a newly developed regional homogeneity (ReHo) approach, we were to explore the features of brain activity in patients with treatment-resistant depression (TRD) in resting state, and further to examine the relationship between abnormal brain activity in TRD patients and specific symptom factors derived ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.02.006

    authors： Guo WB,Sun XL,Liu L,Xu Q,Wu RR,Liu ZN,Tan CL,Chen HF,Zhao JP

    更新日期：2011-07-01 00:00:00

  • Changes of metallothionein I + II proteins in the brain after 1-methyl-4-phenylpyridinium administration in mice.

    abstract：:1-methyl-4-phenylpyridinium (MPP+) is a drug that induces a Parkinson's-like syndrome in several species. Oxidative stress resulting from either excess generation or reduced scavenging of free radicals has been proposed to play a role in its neurotoxicity. It has been suggested that metallothionein (MT) protects again...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(99)00077-9

    authors： Rojas P,Hidalgo J,Ebadi M,Rios C

    更新日期：2000-01-01 00:00:00

  • GABA and endorphin mechanisms in relation to the effects of benzodiazepines on feeding and drinking.

    abstract：:Behavioural actions of benzodiazepines have a number of significant characteristics. Anxiolytic effects are demonstrable both clinically and experimentally; in addition, there is excellent evidence for a reinforcing effect of these compounds, and a direct involvement in ingestional responses. This review focusses on t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90016-7

    authors： Cooper SJ

    更新日期：1983-01-01 00:00:00