Abstract:
:Huntington's disease (HD) is a hereditary disorder clinically characterized by involuntary movements, cognitive decline and psychiatric symptoms. We report on a patient with HD, whose involuntary movements and psychiatric symptoms were clinically improved with perospirone, a second-generation antipsychotic agent with antagonistic effects on serotonin 5-HT(2A) and dopamine D(2) (D(2)) receptors, as well as a unique agonistic effect on serotonin 5-HT(1A) (5-HT(1A)) receptors. The fact that perospirone antagonizes D(2) receptors could explain its effects on the hyperkinetic syndrome, while its agonistic effects on 5-HT(1A) receptors may explain the amelioration of psychiatric symptoms (fear and anxiety) in this patient. Future studies would be valuable to elucidate the utility of perospirone for the treatment of involuntary movements and psychiatric symptoms in HD.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Roppongi T,Togo T,Nakamura S,Asami T,Yoshimi A,Shiozaki K,Kato D,Kawanishi C,Hirayasu Ydoi
10.1016/j.pnpbp.2006.06.021subject
Has Abstractpub_date
2007-01-30 00:00:00pages
308-10issue
1eissn
0278-5846issn
1878-4216pii
S0278-5846(06)00284-3journal_volume
31pub_type
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