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In vitro effects of melatonin on [3H]muscimol binding in rat brain.

Abstract：

:The possible interaction of melatonin with the GABAergic system at the receptor level was investigated. The effect of melatonin on the binding of the GABA agonist, [3H]muscimol, in crude synaptic membrane preparations was assayed. In fresh membrane preparations, melatonin increased [3H]muscimol binding in the rat striatum and frontal cortex. Treatment of membrane preparations with Triton X-100 appeared to abolish or depress the enhancing effect of melatonin. The use of Tris HCl as buffer appeared to be more effective than Tris-Citrate buffer suggesting a possible important ionic effect. The present findings suggest that melatonin is capable of enhancing [3H]muscimol binding in vitro, perhaps at the benzodiazepine-GABA-receptor-ionophore complex.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Coloma FM,Niles LP

doi

10.1016/0278-5846(84)90034-4

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

669-72

issue

4-6

eissn

0278-5846

issn

1878-4216

journal_volume

8

pub_type

杂志文章

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