Memantine augmentation for refractory obsessive-compulsive disorder.

Abstract:

:Glutamatergic hyperactivity hypothesis in obsessive-compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist. We report two cases of refractory obsessive-compulsive disorder treated with an augmentation of memantine at 15 mg/day. The first case did not benefit from such treatment, while the second showed immediate and substantial improvement. Contrasting results, reflecting different subtypes of OCD, are discussed. We hypothesized that in certain OCD subtypes an agent that enhances memory for actions may promote a reduction in orbitofrontal activation.

authors

Pasquini M,Biondi M

doi

10.1016/j.pnpbp.2006.04.013

subject

Has Abstract

pub_date

2006-08-30 00:00:00

pages

1173-5

issue

6

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(06)00175-8

journal_volume

30

pub_type

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