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Neurotoxic effects of amphetamine plus L-DOPA.

Abstract：

:1. Male Swiss Webster mice were administered a series of amphetamine injections preceded by either saline or L-DOPA. 2. This injection regimen was performed for either one, two or three consecutive weeks and neurotoxic effects of the drugs were determined one week later. 3. Amphetamine treatment for two weeks produced a greater striata-dopaminergic lesion that treatment for only one week. Three weeks of treatment did not exacerbate the lesion, indicating that the damage had reached maximal levels. 4. L-DOPA pretreatment did not significantly alter any of the toxic effects of the amphetamine. Therefore, some dopaminergic neurons may be resistant to the toxic effects of amphetamine.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Myers CS,Halladay AK,Widmer DA,Wagner GC

doi

10.1016/s0278-5846(99)00031-7

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

731-40

issue

4

eissn

0278-5846

issn

1878-4216

pii

S0278584699000317

journal_volume

23

pub_type

杂志文章

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