Abstract:
:The antipsychotic drug, bromperidol, is a close structural analogue of haloperidol. These two drugs also have similarities in metabolic pathways and pharmacological properties. In the present study, the prolactin concentrations in plasma during bromperidol versus haloperidol treatments were compared in the same individuals. The subjects were 22 schizophrenic inpatients, who first received bromperidol 12 mg/day for at least 2 weeks followed by haloperidol 12 mg/day. The prolactin concentration in plasma during bromperidol treatment (median and range; 24 and 7-93 ng/ml, respectively) was significantly (P< .01) lower than during haloperidol treatment (32 and 8-102 ng/ml), although the difference was small. The mean (+/- S.D.) plasma concentration of bromperidol was significantly lower than that of haloperidol (20.8+/-8.0 vs. 28.0+/-13.1 nmol/l, P<.05). Prolactin concentrations during both treatment phases correlated well in individuals (r's=.813, P<.001), while no correlation was observed between plasma concentrations of haloperidol and bromperidol (r=.053, ns). These findings suggest that slightly higher prolactin concentration does not necessarily lead to increased risk of hyperprolactinemia during bromperidol treatment compared with haloperidol treatment. In addition, it is suggested that both drugs show similar pharmacodynamic response despite the difference in pharmacokinetics in the same individuals.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Yasui-Furukori N,Kondo T,Suzuki A,Mihara K,Kaneko S,Otani Kdoi
10.1016/s0278-5846(01)00310-4subject
Has Abstractpub_date
2002-04-01 00:00:00pages
575-8issue
3eissn
0278-5846issn
1878-4216pii
S0278-5846(01)00310-4journal_volume
26pub_type
杂志文章abstract::1. We evaluated the behavioral response of guinea pigs to hallucinogenic agents in order to characterize the response of this species to a variety of known hallucinogenic drugs. 2. The systemic injection of LSD in the guinea pig elicited a "myoclonic-like" response the frequency of which was dose-dependent. This behav...
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