当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients.

Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients.

Abstract：

:Ca(2+)-dependent activator protein for secretion 2 (CADPS2), a secretory granule associate protein, mediates monoamine transmission and the release of neurotrophins including brain-derived neurotrophic factor (BDNF) which have been implicated in psychiatric disorders. Furthermore, the expression of CADPS2deltaExon3, a defective splice variant of CADPS2, has been reported to be associated with autism. Based on these observations, we examined whether expression levels of CADPS2 and CADPS2deltaExon3 are altered in psychiatric disorders. Quantitative polymerase chain reaction analysis was performed for postmortem frontal cortex tissues (BA6) from 15 individuals with schizophrenia, 15 with bipolar disorder, 15 with major depression, and 15 controls (Stanley neuropathology consortium). The mean CADPS2 expression levels normalized to human glyceraldehyde-3phosphate dehydrogenase (GAPDH) or TATA-box binding protein levels was found to be significantly increased in the brains of the schizophrenia group, compared to the control group. On the other hand, the ratio of CADPS2deltaExon3 to total CADPS2 was similar in the 4 diagnostic groups. We then analyzed CADPS2 expression in blood samples from 121 patients with schizophrenia and 318 healthy controls; however, there was no significant difference between the two groups. Chronic risperidone treatment did not alter the expression of CADPS2 in frontal cortex of mice. The observed increase in the expression of CADPS2 may be related to the impaired synaptic function in schizophrenia.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Hattori K,Tanaka H,Wakabayashi C,Yamamoto N,Uchiyama H,Teraishi T,Hori H,Arima K,Kunugi H

doi

10.1016/j.pnpbp.2011.05.004

subject

Has Abstract

pub_date

2011-08-15 00:00:00

pages

1738-43

issue

7

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(11)00156-4

journal_volume

35

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Combined treatment of olanzapine and mirtazapine in anorexia nervosa associated with major depression.

    abstract：:Several studies have shown that olanzapine is effective in weight restoration and maintenance for patients with anorexia nervosa (AN). However, major depression is a very common comorbid psychiatric disorder associated with AN. Additional antidepressant therapy may be required for treating anorexic patients with major...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2005.10.004

    authors： Wang TS,Chou YH,Shiah IS

    更新日期：2006-03-01 00:00:00

  • Time course of the changes in antipsychotic-induced hyperprolactinemia following the switch to aripiprazole.

    abstract：:Hyperprolactinemia is an important but neglected adverse effect of antipsychotic medication. All first generation antipsychotics and the second generation antipsychotics amisulpride and risperidone have been shown to cause marked elevation in serum prolactin levels, whereas most other second generation antipsychotics ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2008.09.016

    authors： Lu ML,Shen WW,Chen CH

    更新日期：2008-12-12 00:00:00

  • Causal effects of serum metabolites on amyotrophic lateral sclerosis: A Mendelian randomization study.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that is affected by both genetic and environmental factors. Nowadays, OMIC technologies, such as genomics and metabolomics, are providing a systematic readout of genetic structures and physiological states for understanding human diseases. However, th...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109771

    authors： Yang L,Lv X,Du H,Wu D,Wang M

    更新日期：2020-03-08 00:00:00

  • Emotion regulation in mood and anxiety disorders: A meta-analysis of fMRI cognitive reappraisal studies.

    abstract：:Emotion regulation by means of cognitive reappraisal has been widely studied with functional magnetic resonance imaging (fMRI). To date, several meta-analyses of studies using cognitive reappraisal tasks in healthy volunteers have been carried out, but no meta-analyses have yet been performed on the fMRI data of clini...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.pnpbp.2017.06.001

    authors： Picó-Pérez M,Radua J,Steward T,Menchón JM,Soriano-Mas C

    更新日期：2017-10-03 00:00:00

  • Impaired pre-attentive auditory processing in opioid dependence with and without benzodiazepine co-dependence revealed by combined magnetoencephalography and electroencephalography.

    abstract：:Cognitive dysfunctions may be a significant factor in drug-seeking behavior, reducing the efficiency of rehabilitation in opioid dependence. Neurophysiological basis of these dysfunctions is poorly understood. 21 opioid-dependent patients and 15 healthy controls with no experience of illicit drugs were studied with si...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.06.001

    authors： Kivisaari R,Lehtinen R,Autti T,Puuskari V,Jokela O,Ahveninen J,Rapeli P,Kähkönen S

    更新日期：2007-10-01 00:00:00

  • Oscillatory potentials abnormalities in regular cannabis users: Amacrine cells dysfunction as a marker of central dopaminergic modulation.

    abstract：BACKGROUND:Cannabis is a neuromodulating substance that acts on central synaptic transmission. Regular cannabis use induces a decreased capacity for dopamine synthesis in the brain. The retina is considered an easy means of investigating dysfunctions of synaptic transmission in the brain. We have previously studied the...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2020.110083

    authors： Polli L,Schwan R,Albuisson E,Malbos L,Angioi-Duprez K,Laprevote V,Schwitzer T

    更新日期：2020-08-27 00:00:00

  • Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder.

    abstract：BACKGROUND:Neurological soft signs (NSS) are minor neurological abnormalities, including motor, sensory, and inhibitory dysfunction. Schizophrenia and other neuropsychiatric disorders are associated with a higher prevalence of NSS. However, the relationships between NSS and schizophrenia, bipolar disorder, and major de...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.12.006

    authors： Zhao Q,Ma YT,Lui SS,Liu WH,Xu T,Yu X,Tan SP,Wang ZR,Qu M,Wang Y,Huang J,Cheung EF,Dazzan P,Chan RC

    更新日期：2013-06-03 00:00:00

  • A nicotinic receptor antagonist enhances the hypothermic response to a muscarinic agonist.

    abstract：:1. Chronic treatment with amitriptyline produces supersensitivity to the hypothermic effects of the muscarinic agonist oxotremorine. 2. Chronic treatment with amitriptyline also produces supersensitivity to the hypothermic effects of nicotine. 3. Oxotremorine and other naturally occurring muscarinic agonists are also ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(91)90029-z

    authors： Dilsaver SC,Majchrzak MJ,Snider RM,Davidson RK

    更新日期：1991-01-01 00:00:00

  • Aberrant emotional processing in posterior cortical midline structures in bipolar II depression.

    abstract：:Bipolar II depression is a serious and disabling illness associated with significant impairment and high rates of suicide attempts. However, mechanisms underlying emotional dysregulation in this condition are poorly characterized. The goal of this work was to investigate one component of emotional processing in this d...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.05.017

    authors： Marchand WR,Lee JN,Garn C,Thatcher J,Gale P,Kreitschitz S,Johnson S,Wood N

    更新日期：2011-08-15 00:00:00

  • An MRI study of the basal ganglia in autism.

    abstract：:1. High-resolution MRI scans were obtained from 35 relatively high-functioning persons with autism and 36 healthy controls, comparable in age, gender, and IQ. 2. Volumetric measurements were obtained from manual tracing of the bilateral caudate, putamen, and globus pallidus. 3. An increased volume of the caudate nucle...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(99)00020-2

    authors： Sears LL,Vest C,Mohamed S,Bailey J,Ranson BJ,Piven J

    更新日期：1999-05-01 00:00:00

  • Younger people are more vulnerable to stress, anxiety and depression during COVID-19 pandemic: A global cross-sectional survey.

    abstract：:The COVID-19 pandemic has had far-ranging consequences for general physical and mental health. Country-specific research reveals a general reduction in mental and physical well-being, due to measures undertaken to stop the spread of COVID-19 disease. However, research is yet to examine the impact of the pandemic on gl...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2020.110236

    authors： Varma P,Junge M,Meaklim H,Jackson ML

    更新日期：2020-12-26 00:00:00

  • Differential expression of mitogen-activated protein kinases and immediate early genes fos and jun in thalamus in schizophrenia.

    abstract：:Despite a growing body of evidence demonstrating that mitogen-activated protein (MAP) kinase pathways play an important physiological role in the CNS, little is known about their role and function in various mental disorders including schizophrenia. Our previous studies have shown increased expression of several inter...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.05.017

    authors： Kyosseva SV

    更新日期：2004-09-01 00:00:00

  • Differences of sympathetic and parasympathetic modulation in major depression.

    abstract：:Inconsistent results have been reported with respect to cardiac autonomic function in major depression. The aim of our study was to investigate autonomic function in various branches of the autonomic nervous system in order to better understand parasympathetic and sympathetic modulation in the disease. We investigated...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.07.009

    authors： Schumann A,Andrack C,Bär KJ

    更新日期：2017-10-03 00:00:00

  • Cumulative mean change procedure: application to a comparative trial of venlafaxine, imipramine, and placebo in the treatment of major depression.

    abstract：:1. A simple summary measure--namely, cumulative mean change (CMC)--is proposed for analyzing incomplete repeated measures in clinical settings. 2. A simple test statistic that uses the correlation between subject responses was derived and applied to a study comparing an investigational antidepressant, venlafaxine, wit...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0278-5846(94)90077-9

    authors： Entsuah AR,Bradley MM,Littman GS

    更新日期：1994-07-01 00:00:00

  • All-trans retinoic acid rescues memory deficits and neuropathological changes in mouse model of streptozotocin-induced dementia of Alzheimer's type.

    abstract：:Recent studies have revealed that aberrant vitamin A signaling may lead to memory deficits in rodents. Present study investigates the potential of all-trans-retinoic acid (ATRA) an agonist at retinoid acid family of receptors, in cognitive dysfunctions associated with experimental dementia. Streptozotocin (STZ) [3 mg/...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.09.012

    authors： Sodhi RK,Singh N

    更新日期：2013-01-10 00:00:00

  • Moclobemide, an inhibitor of MAO-A, does not increase daytime plasma melatonin levels in normal humans.

    abstract：:1. Plasma melatonin concentrations were determined after administration of single oral doses (100, 200 and 300 mg) of moclobemide, a reversible inhibitor of monoamine oxidase (MAO) with predominant effects on the A-type of the enzyme, to eight young, healthy male volunteers in a double-blind, random-order, placebo-con...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0278-5846(90)90065-o

    authors： Scheinin M,Koulu M,Vakkuri O,Vuorinen J,Zimmer RH

    更新日期：1990-01-01 00:00:00

  • Learned helplessness and animal models of depression.

    abstract：:The degree to which organisms can exert control over events to which they are exposed has a strong impact on behavior and physiological functioning. Effects caused by the uncontrollability of events that are beyond the organism's control rather than by the events per se have been called learned helplessness effects. T...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：

    authors： Maier SF

    更新日期：1984-01-01 00:00:00

  • Adding a low dose atypical antipsychotic drug to an antidepressant induced a rapid increase of plasma brain-derived neurotrophic factor levels in patients with treatment-resistant depression.

    abstract：:Only two-thirds of depressive patients respond to antidepressant treatment. Recently, addition of an atypical antipsychotic drug to ongoing treatment with an antidepressant has been considered effective and well-tolerated. In the present study, we examined the effects of various atypical antipsychotic drugs as adjuvan...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.12.003

    authors： Yoshimura R,Ikenouchi-Sugita A,Hori H,Umene-Nakano W,Katsuki A,Hayashi K,Ueda N,Nakamura J

    更新日期：2010-03-17 00:00:00

  • Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging.

    abstract：:Memory decline in human aging and dementia is linked to dysfunction of the cholinergic system. Aging dogs demonstrate cognitive impairments and neuropathology that models human aging and dementia. This paper reviews recent evidence suggesting cholinergic involvement in canine cognitive aging based on studies with the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2004.12.008

    authors： Araujo JA,Studzinski CM,Milgram NW

    更新日期：2005-03-01 00:00:00

  • Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status.

    abstract：:Dietary antioxidants might exert an important role in the aging process by relieving oxidative damage, a likely cause of age-associated brain dysfunctions. This study aims to investigate the influence of esculetin (6,7-dihydroxycoumarin), a naturally occurring antioxidant in the diet, on mood-related behaviors and cog...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2015.08.007

    authors： Martín-Aragón S,Villar Á,Benedí J

    更新日期：2016-02-04 00:00:00

  • Differential roles of phospholipases A2 in neuronal death and neurogenesis: implications for Alzheimer disease.

    abstract：:The involvement of phospholipase A(2) (PLA(2)) in Alzheimer disease (AD) was first investigated nearly 15 years ago. Over the years, several PLA(2) isoforms have been detected in brain tissue: calcium-dependent secreted PLA(2) or sPLA(2) (IIA, IIC, IIE, V, X, and XII), calcium-dependent cytosolic PLA(2) or cPLA(2) (IV...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2010.08.019

    authors： Schaeffer EL,da Silva ER,Novaes Bde A,Skaf HD,Gattaz WF

    更新日期：2010-12-01 00:00:00

  • Interactions between mecamylamine and alcohol in Long-Evans rats: flash-evoked potentials, body temperature, behavior, and blood alcohol concentration.

    abstract：:Mecamylamine, a noncompetitive antagonist of nicotinic acetylcholine receptors, has many potential clinical applications, including treating alcohol dependency. However, little is known about the combined effects of mecamylamine and alcohol on visual system electrophysiology. We examined the separate and combined effe...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.11.016

    authors： Hetzler BE,Bauer AM

    更新日期：2013-06-03 00:00:00

  • Activation syndrome induced by the antidepressant tianeptine and suicidal ideation: Evidence from a large depressed outpatient sample.

    abstract：OBJECTIVE:To determine the characteristics of the activation syndrome (AS) that predict the emergence or worsening of suicidal ideation (SI) in the first month of antidepressant treatment with tianeptine, as well as the temporal relationship between both conditions. METHOD:A naturalistic sample of 2422 depressed outpa...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109762

    authors： Lopez-Castroman J,Jaussent I,Gorwood P,Courtet P

    更新日期：2020-03-08 00:00:00

  • Ziprasidone in the treatment of delayed carbon monoxide encephalopathy.

    abstract：:Delayed carbon monoxide (CO) encephalopathy is a serious complication of acute CO poisoning. We present a case of successful treatment of ziprasidone, a newer atypical antipsychotic, in delayed CO encephalopathy. A 52-year-old depressed woman suffered acute CO intoxication after an attempt of suicide by burning charco...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.01.019

    authors： Hu MC,Shiah IS,Yeh CB,Chen HK,Chen CK

    更新日期：2006-06-01 00:00:00

  • Targeting the α7 nicotinic acetylcholine receptor to prevent progressive dementia and improve cognition in adults with Down's syndrome.

    abstract：:As persons with Down's syndrome (DS) age into the third decade and beyond, they develop Alzheimer's disease (AD)-like histopathological changes in brain and may manifest progressive worsening of adaptive functions. Increasingly, persons with DS have near-normal to normal life spans; thus, it has become a therapeutic i...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2014.05.011

    authors： Deutsch SI,Burket JA,Benson AD

    更新日期：2014-10-03 00:00:00

  • Interferon beta ameliorates cognitive dysfunction in a rat model of Alzheimer's disease: Modulation of hippocampal neurogenesis and apoptosis as underlying mechanism.

    abstract：:Neuronal apoptosis and impaired hippocampal neurogenesis are major players in cognitive/memory dysfunctions including Alzheimer's disease (AD). Interferon beta (IFNβ) is a cytokine with anti-apoptotic and neuroprotective properties on the central nervous system (CNS) cells which specifically affects neural progenitor ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2019.109661

    authors： Chavoshinezhad S,Mohseni Kouchesfahani H,Ahmadiani A,Dargahi L

    更新日期：2019-08-30 00:00:00

  • Metabolic treatment of hyperuricosuric autism.

    abstract：:A single male subject with hyperuricosuric autism was treated for a period of 2 years with an oral dose of uridine, which increased from 50 to 500 mg/kg/day. This patient experienced dramatic social, cognitive, language, and motor improvements. These improvement decreased within 72 h of the discontinuation of uridine,...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(01)00249-4

    authors： Page T,Moseley C

    更新日期：2002-02-01 00:00:00

  • Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.

    abstract：:Tryptophan hydroxylase-2 (TPH2) is the rate-limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and has been implicated in the pathogenesis of major depressive disorder (MDD) and in the mechanism of antidepressant action. This study aimed to investigate whether common genetic va...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.02.020

    authors： Tsai SJ,Hong CJ,Liou YJ,Yu YW,Chen TJ,Hou SJ,Yen FC

    更新日期：2009-06-15 00:00:00

  • Pharmacotherapy for major depression in children and adolescents.

    abstract：:Major depression is a serious illness in children which adversely effects their social, academic, and emotional development. It is essential to identify safe and effective medication for the treatment of this disorder in youths. Only some selective serotonin reuptake inhibitors (citalopram, fluoxetine, sertraline) hav...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2005.03.005

    authors： Wagner KD

    更新日期：2005-06-01 00:00:00

  • Subtypes of negative symptoms: the primary subtype in schizophrenic and non-schizophrenic patients.

    abstract：:1. The specificity of negative symptoms remains an open question and requires further research. 2. Subtyping negative symptoms has been showed to be a very relevant point for the identification of primary negative symptoms and for their pharmacotherapy. Negative symptoms as a whole have been demonstrated in schizophre...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(94)90062-0

    authors： Gerbaldo H,Helisch A,Schneider B,Philipp M,Benkert O

    更新日期：1994-03-01 00:00:00