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Cumulative mean change procedure: application to a comparative trial of venlafaxine, imipramine, and placebo in the treatment of major depression.

Abstract：

:1. A simple summary measure--namely, cumulative mean change (CMC)--is proposed for analyzing incomplete repeated measures in clinical settings. 2. A simple test statistic that uses the correlation between subject responses was derived and applied to a study comparing an investigational antidepressant, venlafaxine, with imipramine and placebo. 3. The global fashion in which CMC captured all data confirmed the efficacy advantage of venlafaxine over the two control agents.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Entsuah AR,Bradley MM,Littman GS

doi

10.1016/0278-5846(94)90077-9

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

695-706

issue

4

eissn

0278-5846

issn

1878-4216

pii

0278-5846(94)90077-9

journal_volume

18

pub_type

临床试验,杂志文章,随机对照试验

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