Abstract:
BACKGROUND:Static and dynamic functional connectivity are being increasingly used to measure the effects of disease and a range of different interventions on brain networks. While preliminary evidence suggests that static connectivity can be modulated by chronic antidepressants administration in healthy individuals and in major depression, much less is known about the acute effects of antidepressants especially on dynamic functional connectivity changes. Here we examine acute effects of antidepressants on dynamic functional connectivity within the default mode network. The default mode network is a well described network with many functions in which the role of serotonin is not clear. METHODS:In this work we measured acute pharmacological effects of an infusion of the selective serotonin reuptake inhibitor (SSRI) citalopram (10 mg) in a sample of thirteen healthy volunteers randomised to receive on two occasions the active compound or placebo in a cross over dosing. RESULTS:Acute citalopram administration relative to placebo increased static connectivity between the medial prefrontal cortex and right dorsolateral prefrontal cortex and posterior cingulate cortex. The SSRI also induced a reduction in variability of connectivity with the medial prefrontal cortex in the precuneus and posterior cingulate cortex. DISCUSSION:The measured changes are compatible with modified serotonin cortical availability.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Arnone D,Wise T,Walker C,Cowen PJ,Howes O,Selvaraj Sdoi
10.1016/j.pnpbp.2018.01.021subject
Has Abstractpub_date
2018-06-08 00:00:00pages
152-159issue
Pt Aeissn
0278-5846issn
1878-4216pii
S0278-5846(17)30282-8journal_volume
84pub_type
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