Abstract：
:The symptoms of psychosis and mania are both related to dopaminergic hyperactivity. In psychosis, it is proposed that post-synaptic receptor sensitization causes dysfunctional salience processing, leading to the development of delusional symptoms. In various animal models of psychosis, the mechanism of post-synaptic sensitization is related to the increased proportion of high-affinity D2 receptors. On the other hand, psychostimulant-induced increase in synaptic dopamine can serve as a model for manic distractibility. In this study, brief models were constructed to identify the differences in dopaminergic hyperactivity between psychosis and mania, and the effects of antipsychotics were sought in terms of the dynamics of dopamine receptor occupancy. According to the study, it was found that antipsychotics with small Koff value had advantages in restoring the receptor occupancy to normal level in the psychosis model, while in the mania model, those with large Koff value showed a better profile.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Park SY,Kang UGdoi
10.1016/j.pnpbp.2012.12.014subject
Has Abstractpub_date
2013-06-03 00:00:00pages
89-95eissn
0278-5846issn
1878-4216pii
S0278-5846(12)00325-9journal_volume
43pub_type
杂志文章abstract：:Many antidepressant drugs inhibit the neuronal uptake of norepinephrine, serotonin, epinephrine and/or dopamine. Some newer antidepressant drugs are highly selective in their ability to inhibit the uptake of one or more of these monoamines. This uptake inhibition, which would be expected to increase the synaptic conce...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
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更新日期：1985-01-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,随机对照试验
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更新日期：2017-08-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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更新日期：2003-05-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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doi：10.1016/j.pnpbp.2014.08.002
更新日期：2015-01-02 00:00:00
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更新日期：2002-10-01 00:00:00
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doi：10.1016/j.pnpbp.2007.12.018
更新日期：2008-04-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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doi：10.1016/j.pnpbp.2011.11.008
更新日期：2012-03-30 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2010.05.032
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
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更新日期：1986-01-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2011.05.017
更新日期：2011-08-15 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0278-5846(00)00139-1
更新日期：2000-11-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2007.11.017
更新日期：2008-04-01 00:00:00
abstract：:1. The authors report three cases of neuroleptic induced akathisia resistant to treatment with anticholinergics, benzodiazepines and betablockers. 2. All three patients were treated with Ritanserin 10 mg bid and improved rapidly and substantially. 3. Discontinuation of Ritanserin led to a recurrence of akathisia. ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(92)90076-q
更新日期：1992-03-01 00:00:00
