Metabolism of antidepressants: urinary metabolites of trimipramine in the rat.

abstract：:Treatment of the positive psychotic symptoms of schizophrenia with standard antipsychotic drugs (APDs) is ineffective in a proportion of cases. For these treatment resistant patients the alternative is the APD clozapine which is superior to other agents but carries serious side effects. Why clozapine is uniquely effec...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pereira A,Zhang B,Malcolm P,Sundram S

更新日期：2013-01-10 00:00:00

abstract：:In people with schizophrenia, cognitive abilities - including memory - are strongly associated with functional outcome. Long-term potentiation (LTP) is a form of neuroplasticity that is believed to be the physiological basis for memory. It has been postulated that antipsychotic medication can impair long-term potentia...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Price R,Salavati B,Graff-Guerrero A,Blumberger DM,Mulsant BH,Daskalakis ZJ,Rajji TK

更新日期：2014-10-03 00:00:00

abstract：:Neurocardiac dysregulation has been reported in schizophrenia. Indices of heart rate variability (HRV) are useful in assessing the status of cardiac autonomic regulation. We explored within-subject changes in HRV indices in acutely ill patients with schizophrenia treated with risperidone. Sixteen medication-naïve or m...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Chang JS,Yoo CS,Yi SH,Hong KH,Lee YS,Oh HS,Jung DC,Kim YS,Ahn YM

更新日期：2010-08-16 00:00:00

abstract：:Recent brain imaging studies have shed light on understanding the pathogenesis of mood disorders. Evidence of structural, chemical, and functional brain changes, particularly in prefrontal cortex, cingulate, and amygdala, has been revealed in major depressive disorder (MDD). Furthermore, imaging techniques have been a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bellani M,Dusi N,Yeh PH,Soares JC,Brambilla P

更新日期：2011-08-15 00:00:00

abstract：:The effects of the cytochrome P450 (CYP)2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam were studied in 16 healthy male volunteers. The two mutated alleles (CYP2C19*2 and CYP2C19*3) causing absent CYP2C19 activity were identified by PCR-based restriction e...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Aoshima T,Fukasawa T,Otsuji Y,Okuyama N,Gerstenberg G,Miura M,Ohkubo T,Sugawara K,Otani K

更新日期：2003-05-01 00:00:00

abstract：:Orbitofrontal cortex (OFC) sulcogyral patterns are stable morphological variations established early in life. They consist of three distinct pattern types, with Type III in particular being associated with poor regulatory control (e.g., high sensation seeking and negative emotionality, low constraint), which may confe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Chye Y,Solowij N,Ganella EP,Suo C,Yücel M,Batalla A,Cousijn J,Goudriaan AE,Martin-Santos R,Whittle S,Bartholomeusz CF,Lorenzetti V

更新日期：2017-10-03 00:00:00

abstract：OBJECTIVE:Only two-thirds of depressive patients respond to antidepressant treatment. In recent years, addition of an atypical antipsychotic drug to ongoing treatment with an antidepressant has been considered effective and well-tolerated. In the present study, we compared the efficacy between paroxetine and sertraline...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yoshimura R,Kishi T,Hori H,Ikenouchi-Sugita A,Katsuki A,Umene-Nakano W,Iwata N,Nakamura J

更新日期：2012-12-03 00:00:00

abstract：:Due to global industrialization, the light cycle is shifting to longer daytime. Mounting evidence indicates that social developmental disorders may correlate with longer periods of daytime in childhood. However, the exact mechanisms of this link remain unclear. To examine the impact of longer day-time on psychosocial ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Senoo A,Okuya T,Sugiura Y,Mimura K,Honda Y,Tanaka I,Kodama T,Tokuno H,Yui K,Nakamura S,Usui S,Koshiba M

更新日期：2011-08-01 00:00:00

abstract：:The present study examined the protective effect of hyperbaric oxygen preconditioning (HBO-PC) and the role of thioredoxin reductase (TrxR) in a post-traumatic stress disorder (PTSD)-induced rat model by using single prolonged stress (SPS). Rats were randomly divided into Sham, HBO, SPS and HBO+SPS groups. HBO-PC was ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Peng Y,Feng SF,Wang Q,Wang HN,Hou WG,Xiong L,Luo ZJ,Tan QR

更新日期：2010-08-16 00:00:00

abstract：:Kainic acid (KA)-induced brain neuronal cell death (especially in the hippocampus) was shown to be mainly mediated by the intrinsic (mitochondrial) apoptotic pathway. This study investigated the regulation of the extrinsic apoptotic pathway mediated by Fas ligand/Fas receptor and components of the indispensable death-...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Keller B,García-Sevilla JA

更新日期：2015-12-03 00:00:00

abstract：:The involvement of phospholipase A(2) (PLA(2)) in Alzheimer disease (AD) was first investigated nearly 15 years ago. Over the years, several PLA(2) isoforms have been detected in brain tissue: calcium-dependent secreted PLA(2) or sPLA(2) (IIA, IIC, IIE, V, X, and XII), calcium-dependent cytosolic PLA(2) or cPLA(2) (IV...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Schaeffer EL,da Silva ER,Novaes Bde A,Skaf HD,Gattaz WF

更新日期：2010-12-01 00:00:00

abstract：:The Delusional Misidentification Syndrome (DMS) is thought to be related to dissociation between recognition and identification processes. Working memory (WM) is considered responsible for the integration and online manipulation of information, so that it is available for further processing. Since the P300 component o...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Papageorgiou C,Lykouras L,Ventouras E,Uzunoglu N,Christodoulou GN

更新日期：2002-05-01 00:00:00

abstract：:We studied the interactions between CRL 40028 (benzhydryl sulfinyl) acetohydroxamic acid) and the alpha 1 blocker prazosin, in mouse. CRL 40028 antagonizes prazosin-induced hypothermia and hypomotility; prazosin antagonizes the anticonvulsant effect of CRL 40028 in the quaking mouse. ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Simon P,Chermat R,Puech AJ

更新日期：1983-01-01 00:00:00

abstract：:The use of batteries of single-domain tests for neurophenotyping research is a common strategy to achieve higher data density and explore different behavioral domains. This approach, however, is accompanied by several methodological challenges, briefly discussed here. As an alternative, this paper advocates the wider ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kalueff AV,LaPorte JL,Murphy DL,Sufka K

更新日期：2008-07-01 00:00:00

abstract：:1. After pretraining in an undrugged state, young (6 months) and aged (18-24 months) rats were trained on a spatial learning-set task after receiving one of four doses of diazepam (1, 2, 3 or 5 mg/kg) or the drug vehicle. The effects of 5 mg/kg of diazepam were also assessed on the spatial learning-set task one full h...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： McNamara RK,Davis TM,Skelton RW

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The aims of the present study were to examine the association between a common serotonin transporter gene (SLC6A4) polymorphism 5-HTTLPR/rs25531 with severity of attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) symptoms. METHODS:Mothers and teachers completed a validated DS...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gadow KD,DeVincent CJ,Siegal VI,Olvet DM,Kibria S,Kirsch SF,Hatchwell E

更新日期：2013-01-10 00:00:00

abstract：:1. The acute effects of some of typical and atypical antipsychotic drugs on the dopamine release and metabolism in the dorsal striatum of freely moving rats were studied using transcerebral microdialysis technique. 2. Classical neuroleptic drugs haloperidol (0.05, 0.1 and 0.2 mg/kg), thioproperazine (0.1, 0.2 and 0.4 ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rayevsky KS,Gainetdinov RR,Grekhova TV,Sotnikova TD

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Human brain is a topologically complex network embedded in anatomical space, and anatomical distance may affect functional connectivity (FC) in schizophrenia. However, little is known if and how this effect occurs in adolescent-onset schizophrenia (AOS). METHODS:We explored long- and short-range FC through ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wang S,Zhan Y,Zhang Y,Lyu L,Lyu H,Wang G,Wu R,Zhao J,Guo W

更新日期：2018-02-02 00:00:00

abstract：:Cytokines are pleiotropic molecules with important roles in inflammatory responses. Pro-inflammatory cytokines and neuroinflammation are important not only in inflammatory responses but also in neurogenesis and neuroprotection. Sustained stress and the subsequent release of pro-inflammatory cytokines lead to chronic n...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kim YK,Na KS,Myint AM,Leonard BE

更新日期：2016-01-04 00:00:00

abstract：:1. Male hooded Lister rats were fed a liquid diet containing 10% absolute ethanol for 4-5 weeks. Control rats received the liquid diet in amounts controlled to produce equal weight gain. 2. The rats were tested 7.5 h after withdrawal of ethanol and 30 min after i.p. injection with nitrendipine, chlordiazepoxide or bac...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： File SE,Zharkovsky A,Hitchcott PK

更新日期：1992-01-01 00:00:00

abstract：:Many studies have shown a close relationship between anxiety and beta-adrenergic receptor function in patients with anxiety disorders. This study examined the relationship between beta-adrenergic receptor function and anxiety levels in a normal population. Subjects for this study included 36 men and 44 women between t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kang EH,Yu BH

更新日期：2005-06-01 00:00:00

abstract：:The growing popularity of zebrafish in psychopharmacology and behavioral brain research is partly due to the practicality and simplicity of drug administration in this species. Several drugs may be administered to zebrafish by immersing the fish in the drug solution. Furthermore, numerous drugs developed for mammals, ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zahid H,Tsang B,Ahmed H,Lee RCY,Tran S,Gerlai R

更新日期：2018-04-20 00:00:00

abstract：:We aimed to examine the effects of infertility treatments on the risk of Autism Spectrum Disorder (ASD). Data were from a representative national registry on 110,093 male live births in Israel (born: 1999-2008; and ASD: 975, 0.9%). Infertility treatments included In Vitro Fertilization (IVF), and five hormone treatmen...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Davidovitch M,Chodick G,Shalev V,Eisenberg VH,Dan U,Reichenberg A,Sandin S,Levine SZ

更新日期：2018-08-30 00:00:00

abstract：:1. The great interest for new drugs having cognition enhancing properties is highlighted, particularly for the treatment of dementia of Alzheimer type. 2. A short survey is given of the pharmacological models currently used to mimic cognitive impairment. 3. A systematic survey is given of the major cognition enhancing...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Merlini L,Pinza M

更新日期：1989-01-01 00:00:00

abstract：:Several lines of evidence implicate dysfunction of glutamatergic neurotransmission in opiate dependence and withdrawal. Functional antagonists of glutamatergic system, including compounds acting on both ionotropic and metabotropic glutamate receptors (group I mGlu receptor antagonists and group II mGlu receptor agonis...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pałucha-Poniewiera A,Novák K,Pilc A

更新日期：2009-11-13 00:00:00

abstract：:The present study sought to assess whether the blockade of ionotropic glutamate receptors in the ventral tegmental area (VTA) could modulate the morphine withdrawal in male Sprague-Dawley rats. The effects of dizocilpine (MK-801) or 6,7-dinitroquinnoxaline-2,3-dione (DNQX), ionotropic glutamate receptor antagonists, m...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wang HL,Zhao Y,Xiang XH,Wang HS,Wu WR

更新日期：2004-11-01 00:00:00

abstract：:1. Cerebral blood flow of nine methamphetamine abusers with technetium-99m-hexamethylpropyleneamine oxime (HMPAO) and single photon emission computed tomography (SPECT) as well as morphological examination with magnetic resonance imaging (MRI) were investigated. 2. Six of these subjects exhibited multiple focal perfus...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Iyo M,Namba H,Yanagisawa M,Hirai S,Yui N,Fukui S

更新日期：1997-07-01 00:00:00

abstract：:Over a decade of work by Flynn and colleagues has delineated a network of limbic circuits which function to modulate the expression of predatory aggression and defence in the cat, and aspects of this work are reviewed. In particular, Flynn's work revealed a circuit involving the basomedial amygdala which functions to ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Adamec RE,Stark-Adamec CI

更新日期：1983-01-01 00:00:00

abstract：:Epidemiological studies suggest that perinatal complications, particularly hypoxia-related ones, increase the risk of schizophrenia. Recent genetic studies of the disorder have identified several putative susceptibility genes, some of which are known to be regulated by hypoxia. It can be postulated therefore that birt...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wakuda T,Iwata K,Iwata Y,Anitha A,Takahashi T,Yamada K,Vasu MM,Matsuzaki H,Suzuki K,Mori N

更新日期：2015-01-02 00:00:00

abstract：:Autism spectrum disorder (ASD) is characterized by repetitive behaviors, impaired social communication and stereotyped interests, and often associated with dysregulations in innate/adaptive immune cells. IL-17A has been linked with abnormal behavioral patterns observed in autistic children and animal models of autism....

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Nadeem A,Ahmad SF,Attia SM,Al-Ayadhi LY,Bakheet SA,Al-Harbi NO

更新日期：2019-03-02 00:00:00