当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Regulation of dopamine release and metabolism in rat striatum in vivo: effects of dopamine receptor antagonists.

Regulation of dopamine release and metabolism in rat striatum in vivo: effects of dopamine receptor antagonists.

Abstract：

:1. The acute effects of some of typical and atypical antipsychotic drugs on the dopamine release and metabolism in the dorsal striatum of freely moving rats were studied using transcerebral microdialysis technique. 2. Classical neuroleptic drugs haloperidol (0.05, 0.1 and 0.2 mg/kg), thioproperazine (0.1, 0.2 and 0.4 mg/kg) and spiperone (0.02, 0.04 and 0.07 mg/kg) administered i.p. induced pronounced elevation of extracellular level of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) up to 250-300% to basal level while producing less increase in that of dopamine (DA) (up to 150-170%). 3. Atypical neuroleptics clozapine and thioridazine (both 2, 5 and 20 mg/kg) increased striatal DA release and DOPAC level approximately at the same degree (maximally up to 200% and 160%, respectively). 4. Dopamine D3 receptor and autoreceptor preferring antagonists (+)-UH232 and (+)-AJ76 (both 4, 7 and 14 mg/kg) more potently increased DA release in comparison with DOPAC dialysate level (+)-AJ76 elevated DA level maximally up to 330%, DOPAC-up to 250%). 5. The features of typical and atypical neuroleptics in preferential action on DA release or DOPAC output were observed in all doses of the drugs studied. 6. The ability of the drugs to affect preferentially DA release or DOPAC extracellular level in rat striatum correlates to their relative affinities at D3 and D2 DA receptors. 7. It is concluded that typical and atypical antipsychotic drugs might be clearly distinguished on the basis of their ability to affect preferentially DA synthesis/metabolism or release in rat dorsal striatum in vivo.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Rayevsky KS,Gainetdinov RR,Grekhova TV,Sotnikova TD

doi

10.1016/0278-5846(95)00267-7

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

1285-1303

issue

8

eissn

0278-5846

issn

1878-4216

pii

0278584695002677

journal_volume

19

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Antidepressant drug action--From rapid changes on network function to network rewiring.

    abstract：:There has been significant recent progress in understanding the neurobiological mechanisms of antidepressant treatments. The delayed-onset of action of monoamine-based antidepressant drugs have been associated to their ability to slowly increase synaptic plasticity and neuronal excitability via altering neurotrophic s...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2015.06.001

    authors： Rantamäki T,Yalcin I

    更新日期：2016-01-04 00:00:00

  • A review of epidemiological evidence for general anesthesia as a risk factor for Alzheimer's disease.

    abstract：:Exposure to surgery and general anesthesia (GA) has been hypothesized to be a potential risk factor for the development of Alzheimer's disease (AD). Some basic science research studies have demonstrated AD pathology in animals following exposure to inhalational anesthetics. However, controversy exists as to whether GA...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2012.06.022

    authors： Seitz DP,Reimer CL,Siddiqui N

    更新日期：2013-12-02 00:00:00

  • Effects of olanzapine on aggressiveness in heroin dependent patients.

    abstract：:This study compared the anti-aggressiveness effects of the atypical anti-psychotic olanzapine with that of selective serotonin reuptake inhibitors (SSRI) and benzodiazepines (BZD) among patients with heroin dependence submitted to opioid-agonists substitution treatment. Sixty-seven (67) patients who met the DSM-IV cri...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.pnpbp.2006.04.023

    authors： Gerra G,Di Petta G,D'Amore A,Iannotta P,Bardicchia F,Falorni F,Coacci A,Strepparola G,Campione G,Lucchini A,Vedda G,Serio G,Manzato E,Antonioni M,Bertacca S,Moi G,Zaimovic A

    更新日期：2006-09-30 00:00:00

  • Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants.

    abstract：:1. The effects of intravenous infusion of desipramine (1, 3, 10, and 60 mg/kg/day), amitriptyline, zimelidine, iprindole (3, 10, 30, 60, and 100 mg/kg/day each), imipramine (10, 30, and 100 mg/kg/day), or U-48753E (1, 3, 10, and 30 mg/kg/day) on the density of central beta-adrenergic receptors (beta-AR) were investiga...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(88)90011-5

    authors： Sethy VH,Day JS,Cooper MM

    更新日期：1988-01-01 00:00:00

  • Pharmacogenetics in major depression: a comprehensive meta-analysis.

    abstract：:A number of candidate gene studies focused on major depression (MD) and antidepressant (AD) efficacy have been carried out, but results mainly remain inconclusive. We performed a comprehensive meta-analysis of published candidate gene studies focused on AD efficacy in MD to evaluate the cumulative evidence. A random-e...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.pnpbp.2013.05.011

    authors： Niitsu T,Fabbri C,Bentini F,Serretti A

    更新日期：2013-08-01 00:00:00

  • Regulation of hippocampal Fas receptor and death-inducing signaling complex after kainic acid treatment in mice.

    abstract：:Kainic acid (KA)-induced brain neuronal cell death (especially in the hippocampus) was shown to be mainly mediated by the intrinsic (mitochondrial) apoptotic pathway. This study investigated the regulation of the extrinsic apoptotic pathway mediated by Fas ligand/Fas receptor and components of the indispensable death-...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2015.04.009

    authors： Keller B,García-Sevilla JA

    更新日期：2015-12-03 00:00:00

  • GABA and endorphin mechanisms in relation to the effects of benzodiazepines on feeding and drinking.

    abstract：:Behavioural actions of benzodiazepines have a number of significant characteristics. Anxiolytic effects are demonstrable both clinically and experimentally; in addition, there is excellent evidence for a reinforcing effect of these compounds, and a direct involvement in ingestional responses. This review focusses on t...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(83)90016-7

    authors： Cooper SJ

    更新日期：1983-01-01 00:00:00

  • Nicotine augmentation for refractory obsessive-compulsive disorder. A case report.

    abstract：:The authors present a case of obsessive-compulsive disorder (OCD) resistant to conventional treatments, which improved following nicotine augmentation administered as 4 mg chewing gum. The role of acetylcholine in the pathophysiology of OCD is not clear. The authors discuss the effect of nicotine on memory for actions...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.08.011

    authors： Pasquini M,Garavini A,Biondi M

    更新日期：2005-01-01 00:00:00

  • Skin conductance reaction (SCR)-habituation test, a tool to detect anxiolytic activity. Its justification by the correlation between SCR-habituation test activities and specific binding potencies in benzodiazepines.

    abstract：:Correlation between specific binding potencies "in vitro" of several benzodiazepines and activities in SCR-habituation test is very satisfactory. As the SCR-habituation test might be considered as an elementary model of anxiety state, the test is suggested to be used as an intermediate psychopharmacological tool befor...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(85)90191-5

    authors： Marcy R,Quermonne MA,Raoul J,Nammathao B,Smida A

    更新日期：1985-01-01 00:00:00

  • Veratrine blocks the lamotrigine-induced swimming increase and immobility decrease in the modified forced swimming test.

    abstract：:Lamotrigine exhibits an anti-immobility effect in the modified forced swimming test, increasing swimming and climbing, behaviors that are related to serotonergic and noradrenergic effects, respectively. However, these effects could be secondary to lamotrigine blockade of Na(+) sensitive channel. Thus, this study inves...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.05.017

    authors： Codagnone FT,Consoni FT,Rodrigues AL,Vital MA,Andreatini R

    更新日期：2007-08-15 00:00:00

  • Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke.

    abstract：:Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2015.04.002

    authors： Walker-Batson D,Mehta J,Smith P,Johnson M

    更新日期：2016-01-04 00:00:00

  • Notch1 knockdown disturbed neural oscillations in the hippocampus of C57BL mice.

    abstract：:Neural oscillations and their interactions are associated with the coordination of neural groups, which provide a mechanism underlying information processing of brain functions. Notch1 receptor is involved in the neurological and psychiatric disorders, such as neurodevelopmental deficits, cerebral ischemia, Alzheimer'...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.01.019

    authors： Li Q,Zhang X,Cheng N,Yang C,Zhang T

    更新日期：2018-06-08 00:00:00

  • Significance of gastrointestinal tract in the therapeutic mechanisms of exercise in depression: Synchronism between brain and intestine through GBA.

    abstract：:Researchers have made considerable progress in elucidating psychological and exercise correlates of major depressive disorder (MDD). However, as the largest immune organ, far less is known about the role of gastrointestinal (GI) tract in the therapeutic mechanisms of exercise in MDD. In addition to the sites of the di...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2020.109971

    authors： Liu Y,Xu F,Liu S,Liu G,Yang X,Gao W,Fan K,Zhao H,Ma J

    更新日期：2020-12-20 00:00:00

  • Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in mild and moderate depression.

    abstract：BACKGROUND:Abnormal vasopressin (VP) and oxytocin (OT) signaling may contribute to the altered activity of the hypothalamo-pituitary-adrenal (HPA) axis in major depression; however, the underlying mechanisms remain uncertain. This study characterized plasma levels and affinities of OT- and VP-reactive autoantibodies (a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2010.09.021

    authors： Garcia FD,Coquerel Q,Kiive E,Déchelotte P,Harro J,Fetissov SO

    更新日期：2011-01-15 00:00:00

  • Adjunctive quetiapine in bipolar patients partially responsive to lithium or valproate.

    abstract：:Despite therapeutic treatment with lithium or valproate, patients with bipolar I disorder often require adjunctive therapy to treat persistent symptoms. In order to evaluate the effects of quetiapine for bipolar symptoms inadequately responsive to mood stabilizers, a retrospective chart review was undertaken at the Ve...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0278-5846(03)00145-3

    authors： Sokolski KN,Denson TF

    更新日期：2003-08-01 00:00:00

  • Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: effects of citalopram.

    abstract：:Deficits in serotonergic (5-HT-ergic) neurotransmission and stressful life events have been implicated in affective disorders, and chronic variable stress (CVS) can elicit behavioral changes reminiscent of increased emotionality, anxiety and atypical depression after partial 5-HT depletion. This study examined the eff...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.08.001

    authors： Tõnissaar M,Mällo T,Eller M,Häidkind R,Kõiv K,Harro J

    更新日期：2008-01-01 00:00:00

  • Alterations of synaptic high and low affinity opiate binding sites after acute and chronic morphine administration in mice.

    abstract：:1. The opiate receptor binding to whole brain synaptic membranes obtained from mice subjected to acute and chronic morphine administration and precipitated withdrawal was investigated. 2. The number of high and low affinity binding sites was significantly higher in morphine tolerant group than in control; acute admini...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(82)80187-5

    authors： Sivam SP,Nabeshima T,Ho IK

    更新日期：1982-01-01 00:00:00

  • Effects of stress on the corticolimbic system: implications for chronic pain.

    abstract：:Stress has multifaceted effects on pain. On the one hand, it is a powerful inhibitor of nociception and inflammation; on the other hand, it contributes to enhanced pathological states including the establishment and continuation of chronic pain. These seemingly paradoxical effects can be better understood by investiga...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2017.10.014

    authors： Vachon-Presseau E

    更新日期：2018-12-20 00:00:00

  • Abnormal long- and short-range functional connectivity in adolescent-onset schizophrenia patients: A resting-state fMRI study.

    abstract：BACKGROUND:Human brain is a topologically complex network embedded in anatomical space, and anatomical distance may affect functional connectivity (FC) in schizophrenia. However, little is known if and how this effect occurs in adolescent-onset schizophrenia (AOS). METHODS:We explored long- and short-range FC through ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.08.012

    authors： Wang S,Zhan Y,Zhang Y,Lyu L,Lyu H,Wang G,Wu R,Zhao J,Guo W

    更新日期：2018-02-02 00:00:00

  • Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients.

    abstract：:Ca(2+)-dependent activator protein for secretion 2 (CADPS2), a secretory granule associate protein, mediates monoamine transmission and the release of neurotrophins including brain-derived neurotrophic factor (BDNF) which have been implicated in psychiatric disorders. Furthermore, the expression of CADPS2deltaExon3, a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.05.004

    authors： Hattori K,Tanaka H,Wakabayashi C,Yamamoto N,Uchiyama H,Teraishi T,Hori H,Arima K,Kunugi H

    更新日期：2011-08-15 00:00:00

  • Effects of kawain and dihydromethysticin on field potential changes in the hippocampus.

    abstract：:1. The kava-pyrones kawain and dihydromethysticin are constituents of Piper methysticum which exert anticonvulsant, analgesic and anxiolytic properties. 2. In the present study the effect of these kava-pyrones were tested on field potential changes (fp) induced by omission of the extracellular Mg2+, recorded from the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(97)00042-0

    authors： Walden J,von Wegerer J,Winter U,Berger M,Grunze H

    更新日期：1997-05-01 00:00:00

  • Prolactin and estradiol serum levels in unmedicated male paranoid schizophrenia patients.

    abstract：:There is evidence for the involvement of the endocrine system in schizophrenia. This involment was widely investigated in female patients. In the current study, we examined prolactin and estradiol serum levels in hospitalized unmedicated men with first-episode and recurrent schizophrenia and then tested possible corre...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.09.016

    authors： Segal M,Avital A,Berstein S,Derevenski A,Sandbank S,Weizman A

    更新日期：2007-03-30 00:00:00

  • White matter hyperintensity signals associated with vascular risk factors in schizophrenia.

    abstract：:1. A sample of 165 schizophrenic subjects was compared to a normal control group in order to evaluate associations between white matter hyperintensity signals and vascular risk factors. 2. A comprehensive medical chart review was completed on all subjects evaluating potential vascular risk factors. Brain MRI acquisiti...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(94)00102-n

    authors： Brown FW,Lewine RR,Hudgins PA

    更新日期：1995-01-01 00:00:00

  • At therapeutic concentrations, olanzapine does not affect basal or insulin-stimulated glucose transport in 3T3-L1 adipocytes.

    abstract：:The newer, atypical antipsychotic drugs have improved the treatment of schizophrenia and are widely used. A disadvantage is that they increase food intake, promote weight gain and may facilitate development of diabetes. The mechanism of the latter effect is controversial. A possible interaction of these drugs with glu...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2005.06.008

    authors： Robinson KA,Yacoub Wasef SZ,Buse MG

    更新日期：2006-01-01 00:00:00

  • The effects of chronic ethanol consumption and withdrawal on passive avoidance task and serum cholinesterase level in rats.

    abstract：:The effects of chronic ethanol consumption and ethanol withdrawal on serum cholinesterase (ChE) activity and passive avoidance task in rats were investigated. Ethanol was administered to rats by a modified liquid diet with 4.8% (v/v) ethanol for 3 days followed by 25 days on a liquid diet in which the ethanol concentr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.11.012

    authors： Celik T,Cakir E,Kayir H,Bilgi C,Uzbay IT

    更新日期：2005-05-01 00:00:00

  • Characterisation of spinophilin immunoreactivity in postmortem human brain homogenates.

    abstract：:Spinophilin is a multifunctional scaffold protein that regulates the formation and function of dendritic spines and plays a role in neuronal migration. The distinct roles of spinophilin depend on its localization and the direct interaction with other proteins, which may target spinophilin to specific locations within ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.09.019

    authors： Brocos-Mosquera I,Nuñez Del Moral A,Morentin B,Meana JJ,Callado LF,Erdozain AM

    更新日期：2018-02-02 00:00:00

  • Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables.

    abstract：BACKGROUND:Brain morphometric measures from magnetic resonance imaging (MRI) have not been used to discriminate between first-episode patients with schizophrenia and healthy subjects. METHODS:Magnetic resonance images were acquired from 34 (17 males, 17 females) first-episode schizophrenia patients and 48 (24 males, 2...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2009.09.004

    authors： Takayanagi Y,Kawasaki Y,Nakamura K,Takahashi T,Orikabe L,Toyoda E,Mozue Y,Sato Y,Itokawa M,Yamasue H,Kasai K,Kurachi M,Okazaki Y,Matsushita M,Suzuki M

    更新日期：2010-02-01 00:00:00

  • Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapine.

    abstract：:There is strong evidence that oxygen free radicals may play an important role in the pathophysiology of schizophrenia. Impaired antioxidant defense and increased lipid peroxidation have been previously reported in drug-naïve, first episode and chronically medicated schizophrenic patients using typical neuroleptics. We...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2005.11.009

    authors： Gama CS,Salvador M,Andreazza AC,Kapczinski F,Silva Belmonte-de-Abreu P

    更新日期：2006-05-01 00:00:00

  • Blockade of ionotropic glutamatergic transmission in the ventral tegmental area attenuates the physical signs of morphine withdrawal in rats.

    abstract：:The present study sought to assess whether the blockade of ionotropic glutamate receptors in the ventral tegmental area (VTA) could modulate the morphine withdrawal in male Sprague-Dawley rats. The effects of dizocilpine (MK-801) or 6,7-dinitroquinnoxaline-2,3-dione (DNQX), ionotropic glutamate receptor antagonists, m...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.05.043

    authors： Wang HL,Zhao Y,Xiang XH,Wang HS,Wu WR

    更新日期：2004-11-01 00:00:00

  • Comparison of prolactin concentrations between haloperidol and bromperidol treatments in schizophrenic patients.

    abstract：:The antipsychotic drug, bromperidol, is a close structural analogue of haloperidol. These two drugs also have similarities in metabolic pathways and pharmacological properties. In the present study, the prolactin concentrations in plasma during bromperidol versus haloperidol treatments were compared in the same indivi...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(01)00310-4

    authors： Yasui-Furukori N,Kondo T,Suzuki A,Mihara K,Kaneko S,Otani K

    更新日期：2002-04-01 00:00:00