Abstract：
:Many studies have shown a close relationship between anxiety and beta-adrenergic receptor function in patients with anxiety disorders. This study examined the relationship between beta-adrenergic receptor function and anxiety levels in a normal population. Subjects for this study included 36 men and 44 women between the ages of 20 and 40 years whose Body Mass Index (BMI) was between 18 and 26. All of them were healthy subjects who had no previous history of medical or psychiatric illnesses. The authors measured the Spielberger State-Trait Anxiety Inventory (STAI), Beck Depression Inventory (BDI), and Chronotropic 25 Dose (CD25) of isoproterenol, previously developed to assess in vivo beta-adrenergic receptor sensitivity. We also examined correlations between log normalized CD25 and mood states. The mean of CD25 was 2.64+/-1.37 mug and the mean of CD25 in men was significantly higher (i.e., lower beta-adrenergic receptor sensitivity) than that of women (3.26+/-1.35 vs. 2.14+/-1.17 microg; t = 3.99, p < 0.001). CD25 showed negative correlations with STAI state anxiety (r = -0.344, p = 0.002), trait anxiety (r = -0.331, p = 0.003), and BDI (r = -0.283, p = 0.011). CD25 was positively correlated with BMI (r = 0.423, p < 0.001) and age (r = 0.271, p = 0.015). In stepwise multiple regression analyses, 34% of the variance in CD25 was accounted for by sex, state anxiety, and BMI. The sensitivity of beta-adrenergic receptors increased as anxiety levels became higher in a normal population. Thus, the relationship between anxiety and beta-adrenergic receptor function in healthy subjects may be different from that of patients with anxiety disorders.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Kang EH,Yu BHdoi
10.1016/j.pnpbp.2005.04.027subject
Has Abstractpub_date
2005-06-01 00:00:00pages
733-7issue
5eissn
0278-5846issn
1878-4216pii
S0278-5846(05)00159-4journal_volume
29pub_type
临床试验,杂志文章abstract：:Chronic abusers of alcohol and other drugs often exhibit persistent deficits on neuropsychological tests. These deficits are usually attributed to drug-induced brain dysfunction or to familial factors that depress performance independent of drug abuse. The aim of this study was to determine the plausibility of a third...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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更新日期：2018-03-02 00:00:00
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更新日期：2008-02-15 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2003-06-01 00:00:00
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更新日期：2019-06-08 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2002-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2002-12-01 00:00:00
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更新日期：2017-10-03 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,评审
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更新日期：2016-01-04 00:00:00
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pub_type： 杂志文章
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更新日期：2012-10-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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更新日期：2019-06-08 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2011.03.023
更新日期：2011-07-01 00:00:00
abstract：:Although several recent studies have suggested that neuroinflammation plays a role in depression, both medication and neuroinflammatory preventive strategies have been poorly investigated. Recent studies have indicated that preconditioning with lipopolysaccharide (LPS) reduces the damage that occurs following ischemic...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2020.109978
更新日期：2020-12-20 00:00:00
