Abstract：
:The adrenergic activation of glycogenolysis in the rat liver is converted from an alpha-1 to a beta-2-receptor mediated event in various conditions associated with cellular dedifferentiation. Short-term incubation of isolated hepatocytes in a serum-free medium results in a similar conversion of the adrenoceptor response, without concomitant changes in the density or affinity of alpha-1 or beta-receptor binding sites. This time-dependent conversion can be prevented or reversed by inhibitors of protein synthesis, by an endogenous inhibitor of phospholipase A2 (lipomodulin), or by removal of fatty acids from the medium through a lipid-trap. Conversely, activation of phospholipase A2 or addition of exogenous arachidonic acid to freshly isolated rat liver cells induces an acute conversion from alpha-1 to beta-type response, and the effect of the latter is prevented by the cyclooxygenase inhibitor, ibuprofen. It is proposed that reciprocal changes in alpha-1 and beta-2 receptor activity in rat liver cells are triggered by inverse changes in the coupling of the two receptors to their respective post-receptor pathways. These changes are mediated by a cyclooxygenase product generated through increased phospholipase A2 activity.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Kunos G,Ishac EJ,Nador A,Lapchak Pdoi
10.1016/0278-5846(85)90008-9subject
Has Abstractpub_date
1985-01-01 00:00:00pages
497-502issue
5-6eissn
0278-5846issn
1878-4216journal_volume
9pub_type
杂志文章abstract：:1. The clinical literature regarding the effects of various psychotropic agents on self-injurious behavior is reviewed. Anecdotal reports, open trials and controlled studies are each reviewed. 2. The absence of controlled studies and the failure to distinguish self-injurious behaviors from other forms of aggression ar...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0278-5846(90)90093-v
更新日期：1990-01-01 00:00:00
abstract：:Deficits in decoding and understanding facially expressed emotions occur commonly in persons with autism spectrum disorder (ASD), which contribute to the impairment of social communication that serves as one of its core diagnostic criteria. Research suggests that abnormalities of visual scanning of the face, activatio...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2018.05.009
更新日期：2019-01-10 00:00:00
abstract：:To date, no study has examined the pituitary volumes in patients with hypochondriasis. In the present study, we evaluated pituitary volumes in patients with hypochondriasis and healthy controls. Twenty individuals with hypochondriasis (ten males, ten females), aged 20 to 48 years, and healthy controls were included in...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2009.12.012
更新日期：2010-03-17 00:00:00
abstract：:Stress seems to be an important risk factor in the beginning and continuing stages of cigarette tobacco smoking in humans. Considering that both of nicotine administration and stress exposure affect cognitive functions including memory formation, the aim of the present study was 1) to evaluate the effect of subcutaneo...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2018.05.008
更新日期：2018-08-30 00:00:00
abstract：:Epilepsy is a neurological disorder with significant prevalence and the individuals affected by this disease have a great probability of occurrence of a lethal phenomenon known as Sudden Unexpected Death in Epilepsy (SUDEP). SUDEP occurs mainly during the night and probably during sleep. The pathophysiological mechani...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2014.02.001
更新日期：2014-06-03 00:00:00
abstract：:The effect of electrical vagus nerve stimulation (VNS) on sleep and behavior was analyzed in freely moving cats. Eight cats were prepared for 23-h sleep recordings. The left vagus nerve of four of them was stimulated during 1 min, five times at 1-h intervals, for 5 days. The VNS induces: ipsilateral myosis, blinking, ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0278-5846(01)00228-7
更新日期：2002-01-01 00:00:00
abstract：:1. Two classes of GABAergic inhibitory interneurons, chandelier and basket cells, are known regulators of pyramidal neurons. Parvalbumin (PV) a calcium binding protein, has been shown to be a marker for axon terminals of subpopulations of these interneurons. 2. Immunohistochemical methods were used in this study to ex...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(92)90084-r
更新日期：1992-05-01 00:00:00
abstract：:Depression and impaired quality of life (QOL) are frequently observed in patients suffering from a variety of diseases. In addition, it has been reported that an enhanced degradation of the serotonin precursor tryptophan may contribute to QOL deterioration in some diseases. However, it is unclear whether the correlati...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2009.03.018
更新日期：2009-06-15 00:00:00
abstract：:There is accumulating neuroimaging evidence for both structural and functional abnormalities in schizophrenia patients with persistent auditory verbal hallucinations (AVH). So far, the direct interrelationships between altered structural and functional changes underlying AVH are unknown. Recently, it has become possib...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2019.03.007
更新日期：2019-07-13 00:00:00
abstract：:Neurocardiac dysregulation has been reported in schizophrenia. Indices of heart rate variability (HRV) are useful in assessing the status of cardiac autonomic regulation. We explored within-subject changes in HRV indices in acutely ill patients with schizophrenia treated with risperidone. Sixteen medication-naïve or m...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2010.04.017
更新日期：2010-08-16 00:00:00
abstract：:Linkage studies in bipolar disorder (BPD) suggest that a susceptibility locus exists on chromosome 18p11. The myo-inositol monophosphatase 2 gene (IMPA2) maps to this genomic region. Myo-inositol monophosphatase dephosphorylates inositol monophosphate, regenerating free inositol. Lithium, a common treatment for BPD, h...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,多中心研究
doi：10.1016/j.pnpbp.2010.08.015
更新日期：2010-12-01 00:00:00
abstract：RATIONALE:The endocannabinoid system has been implicated in the neurobiological mechanism underlying drug addiction, especially the primary rewarding dopamine-dependent processes. Therefore, endocannabinoid receptor antagonists, such as the CB1 cannabinoid antagonist rimonabant, have been proposed as candidates for pre...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2014.11.010
更新日期：2015-04-03 00:00:00
abstract：:Recent case reports of postpartum psychosis are reviewed, which suggest hypotheses for the aetiology of this disease. The main themes are: The relationship to manic depression. Premenstrual relapse. Prepartum onset. Onset after miscarriage or evacuation of a trophoblastic tumour. Onset after bromocriptine treatment. A...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0278-5846(94)90001-9
更新日期：1994-05-01 00:00:00
abstract：:Heroin addicts can benefit from methadone substitution therapy. However, little is known about the significance of pre-exposure to opioids for psychoactive effects of methadone. We modeled some behavioral and neurobiological aspects of the opioid abuse-related phenomena in Sprague-Dawley rats, using morphine (10 mg/kg...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2009.05.015
更新日期：2009-08-31 00:00:00
abstract：:Bipolar II depression is a serious and disabling illness associated with significant impairment and high rates of suicide attempts. However, mechanisms underlying emotional dysregulation in this condition are poorly characterized. The goal of this work was to investigate one component of emotional processing in this d...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2011.05.017
更新日期：2011-08-15 00:00:00
abstract：:1. The authors examined the regional cerebral distribution of [Tc-99m] HMPAO using single photon emission computed tomography (SPECT) in patients with major depression and in healthy controls. 2. 19 patients and 16 healthy controls had SPECT images of the brain acquired with 740 MBq (20 mCl) of [Tc-99m] HMPAO on a tri...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(96)00008-5
更新日期：1996-04-01 00:00:00
abstract：:Post-mortem and in-vivo studies support the hypothesis that astrocytes might be involved in the pathogenesis of schizophrenia. To further substantiate this hypothesis two markers of astroglial activation (myo-inositol, S100B) acquired with independent methods ((1)H-MRS, quantitative immunoassay) were concomitantly mea...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2006.09.013
更新日期：2007-03-30 00:00:00
abstract：:1. Agonists may act at any one of three sites on the N-methyl-D-aspartate (NMDA) receptor-effector complex to promote opening of the associated ion channel. The three sites are activated by i) NMDA, L-glutamate, aspartate, and other dicarboxylic amino acids; ii) glycine, D-serine, D-cycloserine, and others; iii) the p...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(91)90079-g
更新日期：1991-01-01 00:00:00
abstract：:Impairment in mismatch negativity (MMN) potentials is a robust finding in schizophrenia. There are few studies which examined the correlation between MMN deficits and neuropsychological performances. The purpose of this study was to investigate the relationship between deficits of tone duration MMN and various neurops...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2007.07.020
更新日期：2008-01-01 00:00:00
abstract：:Amisulpride clearly has the clinical profile of an atypical antipsychotic, characterised in particular by its lower propensity to induce extrapyramidal side effects as well as its greater efficacy in treating negative symptoms compared with classical neuroleptics. In addition to the clinical advantages over classical ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2003.09.006
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:Neurological soft signs (NSS) are minor neurological abnormalities, including motor, sensory, and inhibitory dysfunction. Schizophrenia and other neuropsychiatric disorders are associated with a higher prevalence of NSS. However, the relationships between NSS and schizophrenia, bipolar disorder, and major de...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2012.12.006
更新日期：2013-06-03 00:00:00
abstract：:Post-mortem studies of the human brain indicate that certain GABA(A) receptor subtypes may be differentially altered in schizophrenia. Increased binding to the total population of GABA(A) receptors using [3H]muscimol is observed in the post-mortem schizophrenic brain, yet a proportion of these receptors which bind ben...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2007.10.003
更新日期：2008-02-15 00:00:00
abstract：:Recent neuroimaging studies have characterized the pathophysiology of late-life depression (LLD) as a dysfunction of the brain networks involved in the regulation of emotion, motivational behavior, cognitive control, executive function, and self-referential thinking. In this article, we reviewed LLD-associated structu...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2020.110010
更新日期：2021-01-10 00:00:00
abstract：:The interaction between genes and environment seems to be relevant for the development of Attention Deficit/Hyperactivity Disorder (ADHD), one of the most prevalent childhood psychiatric diseases. The occurrence of ADHD is typically associated with poor academic performance, probably reflecting learning difficulties a...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2009.06.012
更新日期：2009-10-01 00:00:00
abstract：:Codeine is metabolized by the cytochrome P450 2D6 (CYP2D6) to morphine. Codeine is a much weaker agonist at mu opioid receptors than morphine. Therefore, codeine analgesia is highly dependent on CYP2D6 activity. Large prospective studies in the clinical environment do not exist, but it appears reasonable to avoid code...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2006.03.018
更新日期：2006-09-30 00:00:00
abstract：:Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs. Although benzodiazepines improve sleep, their multiple adverse effects hamper their application. Adverse effects include impairment of memory and cognitive functions, next-day hangover and d...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.pnpbp.2011.03.013
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVES:Seasonal affective disorder (SAD) is characterized by a mood lowering in autumn and/or winter followed by spontaneous remission in spring or summer. Bright light (BL) is recognized as the treatment of choice for individuals affected with this disease. It was speculated that BL acts on photosensitive retinal ...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pnpbp.2010.11.009
更新日期：2011-01-15 00:00:00
abstract：:1. The effects of intravenous infusion of desipramine (1, 3, 10, and 60 mg/kg/day), amitriptyline, zimelidine, iprindole (3, 10, 30, 60, and 100 mg/kg/day each), imipramine (10, 30, and 100 mg/kg/day), or U-48753E (1, 3, 10, and 30 mg/kg/day) on the density of central beta-adrenergic receptors (beta-AR) were investiga...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(88)90011-5
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:The high use of long-term benzodiazepines (BZDs) with second-generation antipsychotics (SGAs) has been identified as an important issue in the treatment of schizophrenia in Japan. The aim of this study was to evaluate the effects of gradual reduction or discontinuation of daytime BZD use on cognitive functio...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.pnpbp.2011.11.008
更新日期：2012-03-30 00:00:00
abstract：:1. Male Sprague-Dawley rats were injected with saline, L-Dopa or pargyline. 2. Synaptic vesicles were prepared from whole brain homogenates. Catecholamines and their metabolites in brain tissues and in synaptic vesicles were measured by high performance liquid chromatography with electrochemical detection. 3. L-Dopa a...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
pub_type： 杂志文章
doi：10.1016/0278-5846(89)90147-4
更新日期：1989-01-01 00:00:00
