Abstract：
:Recent brain imaging studies have shed light on understanding the pathogenesis of mood disorders. Evidence of structural, chemical, and functional brain changes, particularly in prefrontal cortex, cingulate, and amygdala, has been revealed in major depressive disorder (MDD). Furthermore, imaging techniques have been applied to monitor the effects of antidepressants (ADs) both in the brains of healthy volunteers and MDD patients. Although with some discrepancies due to the differences in study designs and patient samples, imaging findings have shown that ADs, particularly those having effects on the serotonergic system, modulate the volumes, functions and biochemistry of brain structures, i.e. dorsolateral prefrontal cortex, anterior cingulate and amygdala, which have been demonstrated abnormal in MDD by earlier imaging studies. This paper reviews imaging studies conducted in MDD patients and healthy controls treated with different ADs.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Bellani M,Dusi N,Yeh PH,Soares JC,Brambilla Pdoi
10.1016/j.pnpbp.2010.11.040subject
Has Abstractpub_date
2011-08-15 00:00:00pages
1544-52issue
7eissn
0278-5846issn
1878-4216pii
S0278-5846(10)00471-9journal_volume
35pub_type
杂志文章,评审abstract：:Repeated exposure to stress during childhood is associated with increased risk for neuropsychiatric illness, substance use disorders and other behavioral problems in adulthood. However, it is not clear how chronic childhood stress can lead to emergence of such a wide range of symptoms and disorders in later life. One ...
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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更新日期：2014-10-03 00:00:00
