Abstract：
OBJECTIVE:Only two-thirds of depressive patients respond to antidepressant treatment. In recent years, addition of an atypical antipsychotic drug to ongoing treatment with an antidepressant has been considered effective and well-tolerated. In the present study, we compared the efficacy between paroxetine and sertraline augmented with aripiprazole in patients with refractory major depression. SUBJECTS AND METHODS:Twenty-four patients who met the DSM-IV criteria for major depressive disorder who did not at least two different classes of antidepressants were enrolled in the study. Nine were male and thirteen were female, and their ages ranged from 28 to 66 (mean±SD=39±12) years. Patients were prescribed paroxetine (n=11) or sertraline (n=13) for 4weeks. Then, those whose scores on the 17-item Hamilton Rating Scale for Depression (HAMD17) decreased below 50% received adjunctive therapy of aripiprazole for 4weeks. RESULTS:Although the use of either combination treatment decreased the HAMD17 scores compared to the respective monotherapy, there was no significant difference in HAMD17 scores between the paroxetine plus aripiprazole group and sertraline plus aripiprazole group. CONCLUSION:Aripiprazole augmentation therapy with paroxetine or sertraline was equally effective and tolerated in patients with refractory major depressive order.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Yoshimura R,Kishi T,Hori H,Ikenouchi-Sugita A,Katsuki A,Umene-Nakano W,Iwata N,Nakamura Jdoi
10.1016/j.pnpbp.2012.07.008subject
Has Abstractpub_date
2012-12-03 00:00:00pages
355-7issue
2eissn
0278-5846issn
1878-4216pii
S0278-5846(12)00167-4journal_volume
39pub_type
杂志文章,随机对照试验abstract：:The present study compared retrospectively in a clinical non-experimental setting the efficacy of buprenorphine (BUP) in different subgroups of dually diagnosed and non-dually diagnosed opioid-dependent patients: all the subjects included in the study showed severe long-lasting heroin addiction and 68.4% were affected...
journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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journal_title：Progress in neuro-psychopharmacology & biological psychiatry
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pub_type： 杂志文章
doi：10.1016/0278-5846(94)00102-n
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