Abstract：
INTRODUCTION:Bipolar disorder (BD) patients present a 3-5 fold greater risk of developing type 2 diabetes (T2D) compared to general population. The underlying mechanisms for the increased prevalence of T2D in BD population are poorly understood. OBJECTIVES:The purpose of this review is to critically review evidence suggesting that inflammation may have an important role in the development of both BD and T2D. RESULTS:The literature covered in this review suggests that inflammatory dysregulation take place among many BD patients. Such dysregulated and low grade chronic inflammatory process may also increase the prevalence of T2D in BD population. Current evidence supports the hypothesis of dysregulated inflammatory processes as a critical upstream event in BD as well as in T2D. CONCLUSIONS:Inflammation may be a factor for the development of T2D in BD population. The identification of inflammatory markers common to these two medical conditions will enable researchers and clinicians to better understand the etiology of BD and develop treatments that simultaneously target all aspects of this multi-system condition.
journal_name
Prog Neuropsychopharmacol Biol Psychiatryauthors
Sharma AN,Bauer IE,Sanches M,Galvez JF,Zunta-Soares GB,Quevedo J,Kapczinski F,Soares JCdoi
10.1016/j.pnpbp.2014.06.005subject
Has Abstractpub_date
2014-10-03 00:00:00pages
289-98eissn
0278-5846issn
1878-4216pii
S0278-5846(14)00124-9journal_volume
54pub_type
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