当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Cytokines and soluble adhesion molecules in children and adolescents with a tic disorder.

Cytokines and soluble adhesion molecules in children and adolescents with a tic disorder.

Abstract：

AIM:Dysregulation of the immune system may play a role in tic disorders. We screened for immune disturbances by investigating serum levels of cytokines and soluble adhesion molecules in patients with a tic disorder. METHODS:Serum levels of interleukin (IL)-2, IL-4, IL-5, IL-10, IL-12, soluble IL-2 receptor (sIL2R), tumor necrosis factor (TNF)-α, interferon (IFN)-γ, soluble vascular cell adhesion molecule-1 (sVCAM-1), and intercellular adhesion molecule-1 (sICAM-1) of 66 children and adolescents with a tic disorder and 71 healthy volunteers were compared. We also addressed possible relations between concentrations of the immune markers and severity of tics and comorbid obsessive-compulsive symptoms. RESULTS:Median serum concentrations did not differ significantly between patients and healthy subjects. Serum IL-2 concentrations were positively associated with tic severity ratings; serum IL-12 concentrations negatively with severity ratings of obsessive-compulsive symptoms. CONCLUSIONS:These preliminary findings do not reveal major immune activation in children with a tic disorder but may suggest more subtle disturbances related to disease expression.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Bos-Veneman NG,Bijzet J,Limburg PC,Minderaa RB,Kallenberg CG,Hoekstra PJ

doi

10.1016/j.pnpbp.2010.06.028

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1390-5

issue

8

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(10)00245-9

journal_volume

34

pub_type

杂志文章

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