当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study.

Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study.

Abstract：

BACKGROUND:Recent studies indicate that the traditional Japanese herbal medicine yi-gan san (YGS, yokukan-san in Japanese), a serotonin modulator, may be safe and useful in treating behavioral and psychological symptoms in dementia and borderline personality disorder patients. The authors examined the efficacy, tolerability, and safety of YGS in patients with tardive dyskinesia. METHODS:Twenty-two patients with schizophrenia who had neuroleptic-induced tardive dyskinesia were given 7.5 g/day of YGS for 12 weeks in an open-label study. RESULTS:Administration of YGS resulted in a statistically significant improvement in tardive dyskinesia and psychotic symptoms. CONCLUSIONS:YGS may be an effective and safe therapy to control tardive dyskinesia and psychosis in patients with schizophrenia, that should be further tested in double-blind, placebo-controlled trials.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Miyaoka T,Furuya M,Yasuda H,Hayashida M,Nishida A,Inagaki T,Horiguchi J

doi

10.1016/j.pnpbp.2007.12.003

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

761-4

issue

3

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(07)00431-9

journal_volume

32

pub_type

临床试验,杂志文章,随机对照试验

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