当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP).

Increased plasma glutamate by antipsychotic medication and its relationship to glutaminase 1 and 2 genotypes in schizophrenia -- Juntendo University Schizophrenia Projects (JUSP).

Abstract：

:Disturbed glutamatergic neurotransmission has become recognized as a key component in the pathophysiology of schizophrenia. The change in serum/plasma glutamate with the use of antipsychotic medication has been studied and may be a possible clinical marker. In the present study, we examined plasma glutamate concentration, including a comprehensive investigation of its involvement with clinical course of schizophrenia and a genomic analysis. We performed a case-control genetic association analysis of the glutaminase 1 (GLS) and 2 (GLS2) genes. In addition, the difference in plasma glutamate concentration between the "acute stage" and "remission stage", and the effect of genotypes of SNPs within the two genes were assessed. The genetic association analysis of the GLS and GLS2 genes showed no association with schizophrenia. Plasma glutamate was increased with antipsychotic medication at "remission stage". Although GLS and GLS2 are not likely genetic risk factors for schizophrenia, changes in plasma glutamate concentration might be connected with clinical course of schizophrenia.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Maeshima H,Ohnuma T,Sakai Y,Shibata N,Baba H,Ihara H,Higashi M,Ohkubo T,Nozawa E,Abe S,Ichikawa A,Nakano Y,Utsumi Y,Suzuki T,Arai H

doi

10.1016/j.pnpbp.2007.06.009

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1410-8

issue

7

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(07)00200-X

journal_volume

31

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Adiponectin multimer distribution, not absolute amount of plasma, correlates with depression severity in healthy elderly subjects.

    abstract：:Adiponectin is an adipocyte-specific secretory protein that circulates in serum as three oligomeric complexes known as the high, medium and low molecular weight form (HMW, MMW and LMW). HMW adiponectin has been suggested to be a better predictor of metabolic variables, and it was recently reported that the ratio of HM...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.07.022

    authors： Narita K,Murata T,Hamada T,Takahashi T,Kosaka H,Sudo S,Mizukami K,Yoshida H,Wada Y

    更新日期：2008-01-01 00:00:00

  • Sex-specific differences in corticosterone secretion, behavioral phenotypes and expression of TrkB.T1 and TrkB.FL receptor isoforms: Impact of systemic TrkB inhibition and combinatory stress exposure in adolescence.

    abstract：:Stress exposure has been implicated in the development of mood disorders, although little is known about the lasting effects of repeated stress during the adolescent period on sex-specific differences in endocrine and plasticity-signaling responses in adulthood. Using a 10-day combinatory stress paradigm (postnatal da...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.05.002

    authors： Azogu I,Liang J,Plamondon H

    更新日期：2018-08-30 00:00:00

  • D1/D2 actions of dopaminergic drugs studied with [14C]-2-deoxyglucose autoradiography.

    abstract：:1. To define the neural circuits activated by dopaminergic stimulation in rat models of parkinsonism, the author studied the effects of L-dopa and selective D1 and D2 agonists on RCGU in rats with unilateral 6-OHDA substantia nigra lesions. 2. Systemic administration of L-dopa markedly increased RCGU in the EP and SNr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0278-5846(95)00132-f

    authors： Trugman JM

    更新日期：1995-09-01 00:00:00

  • The impact of glycogen synthase kinase 3β gene on psychotic mania in bipolar disorder patients.

    abstract：OBJECTIVE:The aim of this study was to examine the relationships between glycogen synthase 3β gene polymorphisms and bipolar I disorder, manic in a Korean sample. METHODS:Patients with bipolar disorder (n=118) and a control group (n=158) were assessed by genotyping for GSK3β single nucleotide polymorphisms (SNPs) -172...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.04.006

    authors： Lee YJ,Kim YK

    更新日期：2011-07-01 00:00:00

  • Estradiol, TRH and striatal dopaminergic mechanisms.

    abstract：:1. Estrogens have been shown to decrease the effect of apomorphine in a variety of animal behavioral models reflecting the sensitivity of striatal and mesolimbic dopamine receptors. 2. These include circling, and locomotor activity, in rats and suppression of midbrain tremor as well as lingual dyskinesia in monkeys. 3...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(82)80149-8

    authors： Bédard PJ,Malouin F,Dipaolo T,Labrie F

    更新日期：1982-01-01 00:00:00

  • Learned helplessness and animal models of depression.

    abstract：:The degree to which organisms can exert control over events to which they are exposed has a strong impact on behavior and physiological functioning. Effects caused by the uncontrollability of events that are beyond the organism's control rather than by the events per se have been called learned helplessness effects. T...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：

    authors： Maier SF

    更新日期：1984-01-01 00:00:00

  • Effects of fencamfamine on latent inhibition.

    abstract：:The effects of fencamfamine (FCF), an indirect dopamine (DA) agent, were investigated using the latent inhibition (LI) model of schizophrenia. In the LI procedure, rats preexposed (PE) to an unreinforced stimulus show difficulty in subsequent learning of an association in which that stimulus is predictive of an uncond...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(02)00241-5

    authors： Alves CR,Delucia R,Silva MT

    更新日期：2002-10-01 00:00:00

  • Prefrontal brain metabolites in short-term weight-recovered adolescent anorexia nervosa patients.

    abstract：:Various neuroimaging techniques have revealed morphological and functional alterations in anorexia nervosa (AN), although few spectroscopic magnetic resonance studies have examined short-term weight-recovered AN patients. Subjects were 32 female adolescent patients (between 13 and 18 years old) seen consecutively in o...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2010.05.020

    authors： Castro-Fornieles J,Garcia AI,Lazaro L,Andrés-Perpiñá S,Falcón C,Plana MT,Bargallo N

    更新日期：2010-08-16 00:00:00

  • Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapine.

    abstract：:There is strong evidence that oxygen free radicals may play an important role in the pathophysiology of schizophrenia. Impaired antioxidant defense and increased lipid peroxidation have been previously reported in drug-naïve, first episode and chronically medicated schizophrenic patients using typical neuroleptics. We...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2005.11.009

    authors： Gama CS,Salvador M,Andreazza AC,Kapczinski F,Silva Belmonte-de-Abreu P

    更新日期：2006-05-01 00:00:00

  • Abnormal long- and short-range functional connectivity in adolescent-onset schizophrenia patients: A resting-state fMRI study.

    abstract：BACKGROUND:Human brain is a topologically complex network embedded in anatomical space, and anatomical distance may affect functional connectivity (FC) in schizophrenia. However, little is known if and how this effect occurs in adolescent-onset schizophrenia (AOS). METHODS:We explored long- and short-range FC through ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2017.08.012

    authors： Wang S,Zhan Y,Zhang Y,Lyu L,Lyu H,Wang G,Wu R,Zhao J,Guo W

    更新日期：2018-02-02 00:00:00

  • Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy.

    abstract：:Homocysteine (Hcy) is a sulfur-containing amino acid involved in methionine metabolism. Elevated plasma Hcy concentration is a possible risk factor for vascular disease. Folate and vitamin B-12 are vitamins that are necessary for remethylization of Hcy to methionine. The methylenetetrahydrofolate reductase (MTHFR) is ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.12.018

    authors： Vurucu S,Demirkaya E,Kul M,Unay B,Gul D,Akin R,Gokçay E

    更新日期：2008-04-01 00:00:00

  • Association between TNF-α promoter -308A/G polymorphism and tardive dyskinesian Chinese Han patients with schizophrenia.

    abstract：OBJECTIVE:Previous studies have indicated that the immune may be involved in the pathogenesis of tardive dyskinesia (TD). Some genetic polymorphisms in the human leukocyte antigen (HLA) I and II regions have been associated with TD, and the tumor necrosis factor-α (TNF-α) gene is located in the HLA III region. TNF-α le...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.12.007

    authors： Wang F,Fan H,Sun H,Yang F,Luo Y,Liu H,Kosten TR,Lu L,Zhang XY

    更新日期：2012-04-27 00:00:00

  • VEGF serum levels in depressed patients during SSRI antidepressant treatment.

    abstract：:Recent evidence indicates that the vascular endothelial growth factor (VEGF) may be involved in the neuronal mechanisms underlying both the depression aetiology and the response to pharmacological and non pharmacological antidepressant treatments. To investigate whether VEGF peripheral levels are altered in depression...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2008.11.009

    authors： Ventriglia M,Zanardini R,Pedrini L,Placentino A,Nielsen MG,Gennarelli M,Bocchio-Chiavetto L

    更新日期：2009-02-01 00:00:00

  • Evaluating drug effects on children's cognitive functioning.

    abstract：:In our studies of drug therapy in child psychiatry disorders, we have been using a battery of tests to monitor any effects of medication on the various components of cognitive processing. Our intention was to measure skills required by the children for successful classroom performance. We have used this test battery a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0278-5846(84)90037-x

    authors： Ferguson HB,Simeon JG

    更新日期：1984-01-01 00:00:00

  • Adjunctive quetiapine in bipolar patients partially responsive to lithium or valproate.

    abstract：:Despite therapeutic treatment with lithium or valproate, patients with bipolar I disorder often require adjunctive therapy to treat persistent symptoms. In order to evaluate the effects of quetiapine for bipolar symptoms inadequately responsive to mood stabilizers, a retrospective chart review was undertaken at the Ve...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0278-5846(03)00145-3

    authors： Sokolski KN,Denson TF

    更新日期：2003-08-01 00:00:00

  • Increasing the density of the D2L receptor and manipulating the receptor environment are required to evidence the partial agonist properties of aripiprazole.

    abstract：:The clinical efficacy of aripiprazole in the treatment of psychosis relies on a partial agonism at D2 receptors. As the expression of this receptor differs physiologically between pre- and post-synaptic sites and is affected by pathological conditions or pharmacological treatments, it appears difficult to predict the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.08.007

    authors： Koener B,Focant MC,Bosier B,Maloteaux JM,Hermans E

    更新日期：2012-01-10 00:00:00

  • Of mice and men (and women and children): scientific and ethical implications of animal models.

    abstract：:1. Animal models of human behavior and disease are commonly used and have contributed significantly to progress in understanding the physiological mechanisms of both normal function and disease, and in the development of effective therapies. 2. Little attention has been given, however, to the scientific and ethical im...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0278-5846(00)00139-1

    authors： Bird SJ,Parlee MB

    更新日期：2000-11-01 00:00:00

  • A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder.

    abstract：:Lithium is one of the most commonly used drugs for the treatment of bipolar disorder. To prescribe lithium appropriately to patients, predictors of response to this drug were explored, and several genetic markers are considered to be good candidates. We previously reported a significant association between genetic var...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2007.08.010

    authors： Masui T,Hashimoto R,Kusumi I,Suzuki K,Tanaka T,Nakagawa S,Suzuki T,Iwata N,Ozaki N,Kato T,Takeda M,Kunugi H,Koyama T

    更新日期：2008-01-01 00:00:00

  • A proton spectroscopy study of white matter in children with autism.

    abstract：:White matter abnormalities have been described in autism spectrum disorder (ASD) with mounting evidence implicating these alterations in the pathophysiology of the aberrant connectivity reported in this disorder. The goal of this investigation is to further examine white matter structure in ASD using proton magnetic r...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2015.11.005

    authors： Hardan AY,Fung LK,Frazier T,Berquist SW,Minshew NJ,Keshavan MS,Stanley JA

    更新日期：2016-04-03 00:00:00

  • Oxidative and inflammatory mediators are upregulated in neutrophils of autistic children: Role of IL-17A receptor signaling.

    abstract：:Autism spectrum disorder (ASD) is characterized by repetitive behaviors, impaired social communication and stereotyped interests, and often associated with dysregulations in innate/adaptive immune cells. IL-17A has been linked with abnormal behavioral patterns observed in autistic children and animal models of autism....

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.12.002

    authors： Nadeem A,Ahmad SF,Attia SM,Al-Ayadhi LY,Bakheet SA,Al-Harbi NO

    更新日期：2019-03-02 00:00:00

  • White matter hyperintensity signals associated with vascular risk factors in schizophrenia.

    abstract：:1. A sample of 165 schizophrenic subjects was compared to a normal control group in order to evaluate associations between white matter hyperintensity signals and vascular risk factors. 2. A comprehensive medical chart review was completed on all subjects evaluating potential vascular risk factors. Brain MRI acquisiti...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(94)00102-n

    authors： Brown FW,Lewine RR,Hudgins PA

    更新日期：1995-01-01 00:00:00

  • Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients.

    abstract：BACKGROUND:Suicide is a significant health problem throughout the world. The serotoninergic system is believed to be involved in suicidal behavior and there is evidence of biological abnormalities of two serotonin receptors (HTR2A, HTR2C) and one serotonin transporter (5HTT) in suicide victims. Rs6313 (T102C) of HTR2A ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.09.019

    authors： Zhang J,Shen Y,He G,Li X,Meng J,Guo S,Li H,Gu N,Feng G,He L

    更新日期：2008-02-15 00:00:00

  • Sulpiride treatment of Cotard's syndrome in schizophrenia.

    abstract：:A 33-year-old male suffering from schizophrenia developed the typical symptoms of Cotard's syndrome, i.e., various delusions of negation and severe depressive symptoms. Atypical symptoms such as delusions of persecution and control related to body parts were also observed. These symptoms gradually improved by the trea...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2004.01.011

    authors： Shiraishi H,Ito M,Hayashi H,Otani K

    更新日期：2004-05-01 00:00:00

  • Can we predict treatment response in children with ADHD to a vitamin-mineral supplement? An investigation into pre-treatment nutrient serum levels, MTHFR status, clinical correlates and demographic variables.

    abstract：BACKGROUND:Intent-to-treat analyses from a randomized controlled trial showed significant between-group differences favouring micronutrient treatment on the Clinical Global Impression-Improvement, but no group differences on clinician, parent and teacher ratings of overall ADHD symptoms. There was an advantage of micro...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2018.09.007

    authors： Rucklidge JJ,Eggleston MJF,Darling KA,Stevens AJ,Kennedy MA,Frampton CM

    更新日期：2019-03-08 00:00:00

  • New drug targets in the signaling pathways activated by antidepressants.

    abstract：:Studies of twins, genetic linkage and association support the existence of a genetic component to the susceptibility to depression. Biochemical parameters that change in depressive patients are also observed in their relatives. This indicates that genetic factors control these physiological changes and the susceptibil...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2005.03.017

    authors： Páez-Pereda M

    更新日期：2005-07-01 00:00:00

  • Positive versus negative symptoms in schizophrenia: response to haloperidol.

    abstract：:1. Clinical response to treatment with haloperidol was studied in 20 schizophrenic inpatients with acute exacerbation (DSM-IIIR). 2. Patients were assigned to fixed doses of haloperidol (10, 20 or 30 mg/day) for three weeks. Clinical assessment was made using scales SAPS, SANS, BPRS and Simpson-Angus Scale for rating ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0278-5846(94)90032-9

    authors： Palao DJ,Arauxo A,Brunet M,Marquez M,Bernardo M,Ferrer J,Gonzalez-Monclus E

    更新日期：1994-01-01 00:00:00

  • The effect of haloperidol on met-enkephalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging.

    abstract：:1. Haloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. 2. Haloperidol elevated the beta-end level in AL and CCK level in NIL in young rats only. 3. The SP content in NIL was decreased by haloperidol in all ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(95)00234-0

    authors： Lau SM,Tang F

    更新日期：1995-11-01 00:00:00

  • Hypothetical dopamine dynamics in mania and psychosis--its pharmacokinetic implications.

    abstract：:The symptoms of psychosis and mania are both related to dopaminergic hyperactivity. In psychosis, it is proposed that post-synaptic receptor sensitization causes dysfunctional salience processing, leading to the development of delusional symptoms. In various animal models of psychosis, the mechanism of post-synaptic s...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.12.014

    authors： Park SY,Kang UG

    更新日期：2013-06-03 00:00:00

  • The endogenous alkaloid harmane: acidifying and activity-reducing effects on hippocampal neurons in vitro.

    abstract：RATIONALE:The endogenous alkaloid harmane is enriched in plasma of patients with neurodegenerative or addictive disorders. As harmane affects neuronal activity and viability and because both parameters are strongly influenced by intracellular pH (pH(i)), we tested whether effects of harmane are correlated with altered ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2007.08.043

    authors： Bonnet U,Scherbaum N,Wiemann M

    更新日期：2008-02-15 00:00:00

  • U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists.

    abstract：:1. U-50,488 is a structurally novel, non-mu opioid. In the present experiments it was compared to the reputed kappa opioid agonists, ketazocine, ethylketocyclazocine and bremazocine as regards analgesic cross tolerance to morphine and U-50,488, antagonism of analgesia by naloxone and MR-2266 (in vivo pA2 determination...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(82)80130-9

    authors： Von Voigtlander PF,Lewis RA

    更新日期：1982-01-01 00:00:00