当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > Adiponectin multimer distribution, not absolute amount of plasma, correlates with depression severity in healthy elderly subjects.

Adiponectin multimer distribution, not absolute amount of plasma, correlates with depression severity in healthy elderly subjects.

Abstract：

:Adiponectin is an adipocyte-specific secretory protein that circulates in serum as three oligomeric complexes known as the high, medium and low molecular weight form (HMW, MMW and LMW). HMW adiponectin has been suggested to be a better predictor of metabolic variables, and it was recently reported that the ratio of HMW to total adiponectin or to LMW, not the absolute amount of plasma adiponectin, might be crucial in determining insulin sensitivity. Insulin resistance (IR) is considered to be a primary component of vascular risk factors. Although the association of depression with atherosclerotic vascular diseases has been well documented, the contribution of IR to the evolution and progression of depression-associated vascular morbidity and mortality remains unknown. The current preliminary study showed that the ratio of HMW to total adiponectin or to LMW, not the absolute amount of plasma adiponectin, was negatively associated with depression severity in healthy elderly subjects without metabolic syndrome. This pilot study supports a promising role of adiponectin multimer distribution for clarifying the pathophysiological mechanism by which depression is associated with increased risk for IR, leading to cardiovascular disease, metabolic syndrome or type 2 diabetes.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Narita K,Murata T,Hamada T,Takahashi T,Kosaka H,Sudo S,Mizukami K,Yoshida H,Wada Y

doi

10.1016/j.pnpbp.2007.07.022

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

124-7

issue

1

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(07)00264-3

journal_volume

32

pub_type

杂志文章

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