当前位置： SCI文献检索 > PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY期刊下所有文献 > DRD4 gene and obsessive compulsive disorder: do symptom dimensions have specific genetic correlates?

DRD4 gene and obsessive compulsive disorder: do symptom dimensions have specific genetic correlates?

Abstract：

INTRODUCTION:The dopamine D4 receptor (DRD4) is a promising candidate gene in obsessive compulsive disorder (OCD). A 48-bp variable number of tandem repeats (VNTR) sequence in exon 3 has been studied previously, and alleles containing 2-11 repeats (2R-11R) have been identified. We investigated the association of DRD4 VNTR polymorphism with OCD and its relationship with various clinical parameters (age of onset, gender, family history, co-morbidity, factor-analyzed symptom dimensions and insight). METHODOLOGY:One hundred and seventy three South Indian OCD patients (DSM-IV) recruited from a specialty OCD clinic were evaluated using the Yale-Brown obsessive compulsive scale (YBOCS), YBOCS item-11 for insight, Mini International Neuropsychiatric Interview (MINI) plus, tic disorder subsection of the MINI-KID and Clinical Global Impression scale. 201 healthy controls were evaluated using MINI plus. All subjects were genotyped for the DRD4 VNTR polymorphism. RESULTS:Genotype frequencies did not deviate significantly from the Hardy-Weinberg equilibrium. Case-control association analysis revealed that the 7R allele frequency was significantly greater in OCD patients than controls. This difference was restricted to the women subsample when performing the gender sub-analysis. Among other clinical variables examined, factor 3 (symmetry) was associated with presence of 2R allele. Linear regression analysis confirmed the association of symmetry dimension with the 2R allele (Beta=0.23, t=2.96, p=0.004, CI=0.19-0.95). CONCLUSIONS:Our data provides further evidence that DRD4 VNTR polymorphism is associated with OCD. Furthermore, the presence of the 2R allele was significantly associated with the symmetry dimension. This dimension may represent a more homogeneous subtype of OCD with a genetic etiology.

journal_name

Prog Neuropsychopharmacol Biol Psychiatry

journal_title

Progress in neuro-psychopharmacology & biological psychiatry

authors

Taj M J RJ,Viswanath B,Purushottam M,Kandavel T,Janardhan Reddy YC,Jain S

doi

10.1016/j.pnpbp.2012.10.023

subject

Has Abstract

pub_date

2013-03-05 00:00:00

pages

18-23

eissn

0278-5846

issn

1878-4216

pii

S0278-5846(12)00279-5

journal_volume

41

pub_type

杂志文章

相关文献

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY文献大全
  • Buprenorphine treatment outcome in dually diagnosed heroin dependent patients: A retrospective study.

    abstract：:The present study compared retrospectively in a clinical non-experimental setting the efficacy of buprenorphine (BUP) in different subgroups of dually diagnosed and non-dually diagnosed opioid-dependent patients: all the subjects included in the study showed severe long-lasting heroin addiction and 68.4% were affected...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2005.10.007

    authors： Gerra G,Leonardi C,D'Amore A,Strepparola G,Fagetti R,Assi C,Zaimovic A,Lucchini A

    更新日期：2006-03-01 00:00:00

  • New drug targets in the signaling pathways activated by antidepressants.

    abstract：:Studies of twins, genetic linkage and association support the existence of a genetic component to the susceptibility to depression. Biochemical parameters that change in depressive patients are also observed in their relatives. This indicates that genetic factors control these physiological changes and the susceptibil...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2005.03.017

    authors： Páez-Pereda M

    更新日期：2005-07-01 00:00:00

  • Notch1 knockdown disturbed neural oscillations in the hippocampus of C57BL mice.

    abstract：:Neural oscillations and their interactions are associated with the coordination of neural groups, which provide a mechanism underlying information processing of brain functions. Notch1 receptor is involved in the neurological and psychiatric disorders, such as neurodevelopmental deficits, cerebral ischemia, Alzheimer'...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.01.019

    authors： Li Q,Zhang X,Cheng N,Yang C,Zhang T

    更新日期：2018-06-08 00:00:00

  • Role of interleukin 8 in depression and other psychiatric disorders.

    abstract：:Low grade neuroinflammation has been suggested as one of the underlying mechanisms of many psychiatric diseases as well as cognitive disorders. Interleukin 8 (IL-8), a proinflammatory cytokine produced by many cell types including macrophage and microglia, mainly functions as a neutrophil chemoattractant in the bloods...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2020.110173

    authors： Tsai SJ

    更新日期：2021-03-02 00:00:00

  • Adjunctive quetiapine in bipolar patients partially responsive to lithium or valproate.

    abstract：:Despite therapeutic treatment with lithium or valproate, patients with bipolar I disorder often require adjunctive therapy to treat persistent symptoms. In order to evaluate the effects of quetiapine for bipolar symptoms inadequately responsive to mood stabilizers, a retrospective chart review was undertaken at the Ve...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0278-5846(03)00145-3

    authors： Sokolski KN,Denson TF

    更新日期：2003-08-01 00:00:00

  • Resting-state regional homogeneity as a biological marker for patients with Internet gaming disorder: A comparison with patients with alcohol use disorder and healthy controls.

    abstract：OBJECTIVE:Internet gaming disorder (IGD) shares core clinical features with other addictive disorders, such as gambling disorder and substance use disorder. Designation of IGD as a formal disorder requires elucidation of its neurobiological features and comparison of these with those of other addictive disorders. The a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2015.02.004

    authors： Kim H,Kim YK,Gwak AR,Lim JA,Lee JY,Jung HY,Sohn BK,Choi SW,Kim DJ,Choi JS

    更新日期：2015-07-03 00:00:00

  • Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice.

    abstract：OBJECTIVE:Cadherin-13 (CDH13), a member of the calcium-dependent cell adhesion molecule family, has been linked to neurodevelopmental disorders, including autism spectrum (ASD) and attention-deficit/hyperactivity (ADHD) disorders, but also to depression. In the adult brain, CDH13 expression is restricted e.g. to the pr...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2018.08.010

    authors： Kiser DP,Popp S,Schmitt-Böhrer AG,Strekalova T,van den Hove DL,Lesch KP,Rivero O

    更新日期：2019-03-08 00:00:00

  • Source imaging of P300 auditory evoked potentials and clinical correlations in patients with posttraumatic stress disorder.

    abstract：OBJECTIVE:Posttraumatic stress disorder (PTSD) is associated with abnormal information processing. The P300 component of event-related potentials (ERPs) is known to be a useful marker of information processing. The purposes of this study were to determine the P300 current source density in PTSD patients, and its relati...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.08.002

    authors： Bae KY,Kim DW,Im CH,Lee SH

    更新日期：2011-12-01 00:00:00

  • The effects of antidepressants on human brain as detected by imaging studies. Focus on major depression.

    abstract：:Recent brain imaging studies have shed light on understanding the pathogenesis of mood disorders. Evidence of structural, chemical, and functional brain changes, particularly in prefrontal cortex, cingulate, and amygdala, has been revealed in major depressive disorder (MDD). Furthermore, imaging techniques have been a...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2010.11.040

    authors： Bellani M,Dusi N,Yeh PH,Soares JC,Brambilla P

    更新日期：2011-08-15 00:00:00

  • Clozapine regulation of p90RSK and c-Fos signaling via the ErbB1-ERK pathway is distinct from olanzapine and haloperidol in mouse cortex and striatum.

    abstract：:Treatment of the positive psychotic symptoms of schizophrenia with standard antipsychotic drugs (APDs) is ineffective in a proportion of cases. For these treatment resistant patients the alternative is the APD clozapine which is superior to other agents but carries serious side effects. Why clozapine is uniquely effec...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2012.10.025

    authors： Pereira A,Zhang B,Malcolm P,Sundram S

    更新日期：2013-01-10 00:00:00

  • Antidepressant drug induced alterations in binding to central dopamine transporter sites in the Wistar Kyoto rat strain.

    abstract：:The Wistar Kyoto (WKY) rat has been proposed as an animal model of depressive behavior. Exposing WKY rats to stress stimulation produces symptoms such as anhedonia, psychomotor retardation, ambivalence and negative memory bias. Given the role of the mesolimbic dopamine (DA) system in cognitive, emotional and motivatio...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2005.06.017

    authors： Jiao X,Paré WP,Tejani-Butt SM

    更新日期：2006-01-01 00:00:00

  • Vglut2 haploinsufficiency enhances behavioral sensitivity to MK-801 and amphetamine in mice.

    abstract：:Recently developed mouse models have implicated the vesicular glutamate transporter 2 (VGLUT2) in psychostimulant-induced hyperactivity, a behavioral assay that is often applied to evaluate mouse behavior related to positive schizophrenia (SCZ) symptomatology. In present research, we wanted to evaluate further the rol...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2011.03.023

    authors： Naert A,Callaerts-Vegh Z,Moechars D,Meert T,D'Hooge R

    更新日期：2011-07-01 00:00:00

  • Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder.

    abstract：:In the present study, we tested the hypothesis that the potent and selective dopamine-β-hydroxylase (DβH) inhibitor nepicastat would have minimal effects on cardiovascular and pharmacokinetic parameters associated with cocaine administration and would reduce the positive subjective effects produced by cocaine. We cond...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2015.01.009

    authors： De La Garza R 2nd,Bubar MJ,Carbone CL,Moeller FG,Newton TF,Anastasio NC,Harper TA,Ware DL,Fuller MA,Holstein GJ,Jayroe JB,Bandak SI,Reiman KZ,Neale AC,Pickford LB,Cunningham KA

    更新日期：2015-06-03 00:00:00

  • Dependence potential of antidepressants compared to benzodiazepines.

    abstract：:The aim of the present study was to compare the possible dependence potential of antidepressants (ADs) to benzodiazepines (BZDs). The Schedules for Clinical Assessment in Neuropsychiatry (SCAN), the Benzodiazepine Dependence Self-Report Questionnaire (Bendep-SRQ) and the Symptom Checklist-90 (SCL-90) were administered...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0278-5846(02)00209-9

    authors： van Broekhoven F,Kan CC,Zitman FG

    更新日期：2002-06-01 00:00:00

  • Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals.

    abstract：:It has been reported that personality traits are related to several neurotransmitters. However, the association between personality traits and the central nervous system remains unclear. In the present study, we investigated the relationships between a polymorphism involving a variable number of tandem repeats in the ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2008.09.012

    authors： Tsuchimine S,Yasui-Furukori N,Kaneda A,Saito M,Nakagami T,Sato K,Kaneko S

    更新日期：2008-12-12 00:00:00

  • Psychological traits and platelet monoamine oxidase activity in eating disorder patients: their relationship and stability.

    abstract：:Self-reported behavior and attitudes towards eating [Eating Disorder Inventory-2; Garner DM (1991). Eating Disorder Inventory-2: Professional Manual. Odessa, Fl.: Psychological Assessment Resources; Estonian version Podar I, Hannus A, Allik J (1999). Personality and Affectivity Characteristics Associated With Eating D...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.06.025

    authors： Podar I,Jaanisk M,Allik J,Harro J

    更新日期：2007-01-30 00:00:00

  • A pilot clinical trial of oxcarbazepine in adults with attention-deficit hyperactivity disorder.

    abstract：:Despite the increasing recognition of attention-deficit hyperactivity disorder (ADHD) in adults, there is a paucity of controlled pharmacological trials. Recent reports have suggested the potential usefulness of mood stabilizing drugs for ADHD. To this end, the authors completed a pilot study with oxcarbazepine for th...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.pnpbp.2006.03.035

    authors： Davids E,Kis B,Specka M,Gastpar M

    更新日期：2006-08-30 00:00:00

  • The NVL gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population.

    abstract：:NVL (nuclear VCP (valosin containing protein)/p97-Like), a member of the AAA-ATPase (ATPases associated with various cellular activities) family, encodes a novel hTERT (human telomerase reverse transcriptase)-interacting protein NVL2 which is a telomerase component essential for holoenzyme assembly. Previous researche...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2015.04.001

    authors： Wang M,Chen J,He K,Wang Q,Li Z,Shen J,Wen Z,Song Z,Xu Y,Shi Y

    更新日期：2015-10-01 00:00:00

  • Changes in motor cortical excitability in schizophrenia following transcranial direct current stimulation.

    abstract：:Schizophrenia is a disorder associated with cortical inhibition deficits. Transcranial direct current stimulation (tDCS) induces changes in cortical excitability in healthy subjects and individuals with neuropsychiatric disorders depending on the stimulation parameters. Our aim was to investigate whether a previously ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2018.11.004

    authors： Gordon PC,Valiengo LDCL,de Paula VJR,Galhardoni R,Ziemann U,de Andrade DC,Brunoni AR

    更新日期：2019-03-02 00:00:00

  • Abnormal cerebral perfusion in chronic methamphetamine abusers: a study using 99MTc-HMPAO and SPECT.

    abstract：:1. Cerebral blood flow of nine methamphetamine abusers with technetium-99m-hexamethylpropyleneamine oxime (HMPAO) and single photon emission computed tomography (SPECT) as well as morphological examination with magnetic resonance imaging (MRI) were investigated. 2. Six of these subjects exhibited multiple focal perfus...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0278-5846(97)00079-1

    authors： Iyo M,Namba H,Yanagisawa M,Hirai S,Yui N,Fukui S

    更新日期：1997-07-01 00:00:00

  • Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol.

    abstract：:Post-mortem and in-vivo studies support the hypothesis that astrocytes might be involved in the pathogenesis of schizophrenia. To further substantiate this hypothesis two markers of astroglial activation (myo-inositol, S100B) acquired with independent methods ((1)H-MRS, quantitative immunoassay) were concomitantly mea...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2006.09.013

    authors： Rothermundt M,Ohrmann P,Abel S,Siegmund A,Pedersen A,Ponath G,Suslow T,Peters M,Kaestner F,Heindel W,Arolt V,Pfleiderer B

    更新日期：2007-03-30 00:00:00

  • Neutral amino acid availability in two major psychiatric disorders.

    abstract：:1. Evidence suggests catecholamines and indoleamines may play a role in the pathogenesis of several psychiatric disorders. These neurotransmitters (i.e. dopamine, norepinephrine and serotonin) are synthesized within the human brain from their precursors, the aromatic large neutral amino acids tyrosine and tryptophan. ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0278-5846(95)00106-6

    authors： Lucca A,Lucini V,Catalano M,Smeraldi E

    更新日期：1995-07-01 00:00:00

  • Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality.

    abstract：:Amisulpride clearly has the clinical profile of an atypical antipsychotic, characterised in particular by its lower propensity to induce extrapyramidal side effects as well as its greater efficacy in treating negative symptoms compared with classical neuroleptics. In addition to the clinical advantages over classical ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2003.09.006

    authors： Möller HJ

    更新日期：2003-10-01 00:00:00

  • Neurocognitive deficits and quality of life in outpatients with schizophrenia.

    abstract：:The purpose of this cross-sectional study was to examine the relationships between neurocognitive deficits and quality of life for patient with schizophrenia. Fifty-seven schizophrenic outpatients (38 men and 19 women) were assessed for neurocognitive deficits using the Wisconsin Card Sorting Test (WCST) and all patie...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0278-5846(02)00217-8

    authors： Aksaray G,Oflu S,Kaptanoğlu C,Bal C

    更新日期：2002-10-01 00:00:00

  • Neurocognitive endophenotypes in schizophrenia: modulation by nicotinic receptor systems.

    abstract：:Cigarette smoking is the leading preventable cause of death in the Western world, with a considerably higher prevalence observed in schizophrenia compared to the general population. Despite the negative health consequences of smoking heavily, it has been proposed that individuals with schizophrenia may maintain smokin...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.pnpbp.2013.07.010

    authors： Mackowick KM,Barr MS,Wing VC,Rabin RA,Ouellet-Plamondon C,George TP

    更新日期：2014-07-03 00:00:00

  • The effect of haloperidol on met-enkephalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging.

    abstract：:1. Haloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. 2. Haloperidol elevated the beta-end level in AL and CCK level in NIL in young rats only. 3. The SP content in NIL was decreased by haloperidol in all ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0278-5846(95)00234-0

    authors： Lau SM,Tang F

    更新日期：1995-11-01 00:00:00

  • Hyperbaric oxygen preconditioning ameliorates anxiety-like behavior and cognitive impairments via upregulation of thioredoxin reductases in stressed rats.

    abstract：:The present study examined the protective effect of hyperbaric oxygen preconditioning (HBO-PC) and the role of thioredoxin reductase (TrxR) in a post-traumatic stress disorder (PTSD)-induced rat model by using single prolonged stress (SPS). Rats were randomly divided into Sham, HBO, SPS and HBO+SPS groups. HBO-PC was ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.pnpbp.2010.05.016

    authors： Peng Y,Feng SF,Wang Q,Wang HN,Hou WG,Xiong L,Luo ZJ,Tan QR

    更新日期：2010-08-16 00:00:00

  • Genome-wide association meta-analysis of cocaine dependence: Shared genetics with comorbid conditions.

    abstract：:Cocaine dependence is a complex psychiatric disorder that is highly comorbid with other psychiatric traits. Twin and adoption studies suggest that genetic variants contribute substantially to cocaine dependence susceptibility, which has an estimated heritability of 65-79%. Here we performed a meta-analysis of genome-w...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.pnpbp.2019.109667

    authors： Cabana-Domínguez J,Shivalikanjli A,Fernàndez-Castillo N,Cormand B

    更新日期：2019-08-30 00:00:00

  • Positive versus negative symptoms in schizophrenia: response to haloperidol.

    abstract：:1. Clinical response to treatment with haloperidol was studied in 20 schizophrenic inpatients with acute exacerbation (DSM-IIIR). 2. Patients were assigned to fixed doses of haloperidol (10, 20 or 30 mg/day) for three weeks. Clinical assessment was made using scales SAPS, SANS, BPRS and Simpson-Angus Scale for rating ...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0278-5846(94)90032-9

    authors： Palao DJ,Arauxo A,Brunet M,Marquez M,Bernardo M,Ferrer J,Gonzalez-Monclus E

    更新日期：1994-01-01 00:00:00

  • Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study.

    abstract：BACKGROUND:Recent studies indicate that the traditional Japanese herbal medicine yi-gan san (YGS, yokukan-san in Japanese), a serotonin modulator, may be safe and useful in treating behavioral and psychological symptoms in dementia and borderline personality disorder patients. The authors examined the efficacy, tolerab...

    journal_title：Progress in neuro-psychopharmacology & biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.pnpbp.2007.12.003

    authors： Miyaoka T,Furuya M,Yasuda H,Hayashida M,Nishida A,Inagaki T,Horiguchi J

    更新日期：2008-04-01 00:00:00